Abstract:
:Human T-cell leukaemia virus (HTLV), first isolated in the United States from a patient with cutaneous T-cell lymphoma, is a unique horizontally transmitted retrovirus which is highly associated with certain adult T-cell malignancies. Also, HTLV can be transmitted in vitro to cord blood T-lymphocytes. In the accompanying paper it was shown that all T cells producing HTLV, whether cultured from infected persons or infected in vitro, bind a monoclonal antibody (4D12) which recognizes an epitope shared by certain cross-reactive class I major histocompatibility antigens. This antigen may account for the extra HLA-A and -B specificities detected in HTLV-infected cells using alloantisera. Because of the unusual findings of apparently inappropriate HLA antigens in HTLV infected cells, we had previously looked for rearrangement of class I-related genes in HTLV infected cells but failed to find any. Here, using molecular clones of HTLV and human major histocompatibility antigen DNA, we have shown homology between the envelope gene region of HTLV and the region of an HLA-B locus gene which codes for the extracellular portion of a class I histocompatibility antigen.
journal_name
Naturejournal_title
Natureauthors
Clarke MF,Gelmann EP,Reitz MS Jrdoi
10.1038/305060a0subject
Has Abstractpub_date
1983-09-01 00:00:00pages
60-2issue
5929eissn
0028-0836issn
1476-4687journal_volume
305pub_type
杂志文章相关文献
NATURE文献大全abstract::The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14498
更新日期:2015-06-18 00:00:00
abstract::Activity-induced changes in the efficacy of synaptic transmission between neurones are central to several prominent theories of learning. In both in vivo and in vitro preparations of the hippocampus, a conditioning high-frequency stimulus delivered to afferent fibres results in a long-term potentiation of synaptic tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320529a0
更新日期:1986-04-10 00:00:00
abstract::B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that these tumours are dependent on the RAF/MEK/ERK pathway, offered hope that inhibition of B-RAF kinase activity could benefit melanoma patients. He...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09454
更新日期:2010-09-30 00:00:00
abstract::Many precious, 'iron-loving' metals, such as gold, are surprisingly abundant in the accessible parts of the Earth, given the efficiency with which core formation should have removed them to the planet's deep interior. One explanation of their over-abundance is a 'late veneer'--a flux of meteorites added to the Earth a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10399
更新日期:2011-09-07 00:00:00
abstract::Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature14180
更新日期:2015-04-30 00:00:00
abstract::H-2 class I antigens appear to direct the recognition of virus-infected and neoplastic transformed cells by cytotoxic T lymphocytes (CTLs). Here, to identify the regions of class I antigens involved in CTL recognition, four hybrid class I genes were constructed in which exons were exchanged between the H-2Kb and H-2Db...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309279a0
更新日期:1984-05-17 00:00:00
abstract::Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05850
更新日期:2007-05-31 00:00:00
abstract::When a portrait is coarsely quantized into blocks, the block structure hides the face, although lower spatial frequencies of the original image sufficient by themselves for recognition are preserved. Recognition can be recovered by blurring the image, or otherwise attenuating the spurious higher spatial frequency comp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305226a0
更新日期:1983-09-15 00:00:00
abstract::In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355365a0
更新日期:1992-01-23 00:00:00
abstract::Among the pathological effects in man following infection with Mycoplasma pneumoniae is a transient autoimmune disorder characterized by the presence of high-titre erythrocyte autoantibodies (cold agglutinins). These autoantibodies are usually directed against the carbohydrate antigen termed I (ref. 3) which consists ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307560a0
更新日期:1984-02-09 00:00:00
abstract::All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-depend...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01473
更新日期:2003-03-13 00:00:00
abstract::Cyclic ADP-ribose (cADPR) is a newly identified nucleotide which can release calcium from a variety of cells, suggesting it is a messenger for mobilizing internal Ca2+ stores. Its cyclic structure has now been confirmed by X-ray crystallography. Available results are consistent with it being a modulator of Ca(2+)-indu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370307a0
更新日期:1994-07-28 00:00:00
abstract::The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/16946
更新日期:1999-01-28 00:00:00
abstract::The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06866
更新日期:2008-05-01 00:00:00
abstract::The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/256556a0
更新日期:1975-08-14 00:00:00
abstract::Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10244
更新日期:2011-07-20 00:00:00
abstract::The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/333742a0
更新日期:1988-06-23 00:00:00
abstract::Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an ep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02157
更新日期:2003-12-04 00:00:00
abstract::Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304447a0
更新日期:1983-08-04 00:00:00
abstract::Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04822
更新日期:2006-06-01 00:00:00
abstract::Phylogenetic analysis of early tetrapod evolution has resulted in a consensus across diverse data sets in which the tetrapod stem group is a relatively homogenous collection of medium- to large-sized animals showing a progressive loss of 'fish' characters as they become increasingly terrestrial, whereas the crown grou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22966
更新日期:2017-06-29 00:00:00
abstract::A decision is a commitment to a proposition or plan of action based on evidence and the expected costs and benefits associated with the outcome. Progress in a variety of fields has led to a quantitative understanding of the mechanisms that evaluate evidence and reach a decision. Several formalisms propose that a repre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08275
更新日期:2009-09-10 00:00:00
abstract::Self-propagating beta-sheet-rich protein aggregates are implicated in a wide range of protein-misfolding phenomena, including amyloid diseases and prion-based inheritance. Two properties have emerged as common features of amyloids. Amyloid formation is ubiquitous: many unrelated proteins form such aggregates and even ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01894
更新日期:2003-08-21 00:00:00
abstract::Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387422a0
更新日期:1997-05-22 00:00:00
abstract::The fundus of the guinea-pig stomach actively dilates in response to low increases in intragastric pressure. This physiological response, now called adaptive relaxation, accommodates the intake of liquid or food. It is independent of external innervation, resistant to ganglion blockade, but reflex in origin. The nerve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351477a0
更新日期:1991-06-06 00:00:00
abstract::Fusion of biological membranes is mediated by specific lipid-interacting proteins that induce the formation and expansion of an initial fusion pore. Here we report the crystal structure of the ectodomain of the Semliki Forest virus fusion glycoprotein E1 in its low-pH-induced trimeric form. E1 adopts a folded-back con...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02239
更新日期:2004-01-22 00:00:00
abstract::FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence. Because of its unusual bipartite nature, FokI has been used to create artificial enzymes with new specificities. We have determined the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40446
更新日期:1997-07-03 00:00:00
abstract::The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287738a0
更新日期:1980-10-23 00:00:00
abstract::For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08920
更新日期:2010-04-01 00:00:00
abstract::Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04542
更新日期:2006-03-16 00:00:00