Abstract：
:Cyclic ADP-ribose (cADPR) is a newly identified nucleotide which can release calcium from a variety of cells, suggesting it is a messenger for mobilizing internal Ca2+ stores. Its cyclic structure has now been confirmed by X-ray crystallography. Available results are consistent with it being a modulator of Ca(2+)-induced Ca2+ release. Here we report that sea urchin egg microsomes purified by Percoll gradients lose sensitivity to cADPR, but the response can be restored by a soluble protein in the supernatant. Purification and characterization of the protein indicate that it is calmodulin. It appears to be sensitizing the Ca2+ release mechanism because caffeine and strontium, agonists of Ca(2+)-induced Ca2+ release, can also mimic calmodulin in conferring cADPR-sensitivity. Although evidence indicates that cADPR may be an activator of the ryanodine receptor, present results point to the importance of accessory proteins such as calmodulin in modulating its activity.
journal_name
Naturejournal_title
Natureauthors
Lee HC,Aarhus R,Graeff R,Gurnack ME,Walseth TFdoi
10.1038/370307a0subject
Has Abstractpub_date
1994-07-28 00:00:00pages
307-9issue
6487eissn
0028-0836issn
1476-4687journal_volume
370pub_type
杂志文章相关文献
NATURE文献大全abstract：:Ultrafast time-resolved optical spectroscopy has revealed new classes of physical, chemical and biological reactions, in which directed, deterministic motions of atoms have a key role. This contrasts with the random, diffusive motion of atoms across activation barriers that typically determines kinetic rates on slower...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35065045
更新日期：2001-03-01 00:00:00
abstract：:Analysis of a series of mutants of an Escherichia coli alanine transfer RNA shows that substitution of a single G-U base pair in the acceptor helix eliminates aminoacylation with alanine in vivo and in vitro. Introduction of that base pair into the analogous position of a cysteine and a phenylalanine transfer RNA conf...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/333140a0
更新日期：1988-05-12 00:00:00
abstract：:Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10523
更新日期：2011-10-26 00:00:00
abstract：:Although directed migration is a feature of both individual cells and cell groups, guided migration has been studied most extensively for single cells in simple environments. Collective guidance of cell groups remains poorly understood, despite its relevance for development and metastasis. Neural crest cells and neuro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05965
更新日期：2007-07-19 00:00:00
abstract：:Earthquakes radiate from slip on discrete faults, but also commonly involve distributed deformation within a broader fault zone, especially near the surface. Variations in rock strain during an earthquake are caused by heterogeneity in the elastic stress before the earthquake, by variable material properties and geome...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07817
更新日期：2009-03-05 00:00:00
abstract：:Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/303256a0
更新日期：1983-05-19 00:00:00
abstract：:Mammalian neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspartate (NMDA) or aspartate, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate. An important aspect of NMDA receptors is their regulation by a variety of factors such...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/345347a0
更新日期：1990-05-24 00:00:00
abstract：:The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22313
更新日期：2017-05-11 00:00:00
abstract：:The structure of water near non-polar molecular fragments or surfaces mediates the hydrophobic interactions that underlie a broad range of interfacial, colloidal and biophysical phenomena. Substantial progress over the past decade has improved our understanding of hydrophobic interactions in simple model systems, but ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14018
更新日期：2015-01-15 00:00:00
abstract：:The respiratory organs of terrestrial insects consist of tracheal tubes with external spiracular valves that control gas exchange. Despite their relatively high metabolic rate, many insects have highly discontinuous patterns of gas exchange, including long periods when the spiracles are fully closed. Two explanations ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03106
更新日期：2005-02-03 00:00:00
abstract：:Change history: In Fig. 1b and c of this Letter, the inset times in the DIC and GFP microscopy images should be in minutes ('min') instead of seconds ('s'). This has not been corrected online. ...
journal_title：Nature
pub_type： 已发布勘误
doi：10.1038/s41586-019-1327-8
更新日期：2019-07-01 00:00:00
abstract：:The Philadelphia chromosome, a chromosomal abnormality that encodes BCR-ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed a genome-wide analysis of diagnostic leuk...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06866
更新日期：2008-05-01 00:00:00
abstract：:Recent studies have suggested a critical role of specific gene loss in several embryonic tumours and certain adult cancers. In retinoblastoma, hemizygosity or homozygosity of a recessive mutant allele results in the loss of normal gene product, and this seems to cause the manifestation of the disorder. Familial polypo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/331273a0
更新日期：1988-01-21 00:00:00
abstract：:The Arabidopsis thaliana protein UVR8 is a photoreceptor for ultraviolet-B. Upon ultraviolet-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, which triggers a signalling pathway for ultraviolet protection. The mechanism by which UVR8 senses ultraviolet-B remains largely unknown. Here we rep...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10931
更新日期：2012-02-29 00:00:00
abstract：:The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature07425
更新日期：2008-11-06 00:00:00
abstract：:Butterflies rely extensively on colour vision to adapt to the natural world. Most species express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eyes), which are distributed stochastically across the retina. The retinas of Drosophila melanogaster use just two main types, in whic...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature18616
更新日期：2016-07-14 00:00:00
abstract：:Atlantic tropical cyclone activity, as measured by annual storm counts, reached anomalous levels over the past decade. The short nature of the historical record and potential issues with its reliability in earlier decades, however, has prompted an ongoing debate regarding the reality and significance of the recent ris...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08219
更新日期：2009-08-13 00:00:00
abstract：:The recent discovery that the human T-cell lymphoma leukemia virus (HTLV) may be the agent of transmission of T-cell lymphoid malignancies raises ethical questions for blood transfusion services. The effort to avoid use of contaminated blood is dependent to a large extent on the willingness and ability of donors to g...
journal_title：Nature
pub_type： 新闻
doi：10.1038/302567a0
更新日期：1983-04-14 00:00:00
abstract：:Humans and cats can localize a sound source accurately if its spectrum is fairly broad and flat, as is typical of most natural sounds. However, if sounds are filtered to reduce the width of the spectrum, they result in illusions of sources that are very different from the actual locations, particularly in the up/down ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/21424
更新日期：1999-06-17 00:00:00
abstract：:Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1817-8
更新日期：2020-01-01 00:00:00
abstract：:Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-mediated aggregation of CD4 (to mimic interaction with its ligand, majo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/350062a0
更新日期：1991-03-07 00:00:00
abstract：:Where continental plates break apart, slip along multiple normal faults provides the required space for the Earth's crust to thin and subside. After initial rifting, however, the displacement on normal faults observed at the sea floor seems not to match the inferred extension. Here we show that crustal thinning can be...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04608
更新日期：2006-03-16 00:00:00
abstract：:The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/321702a0
更新日期：1986-06-12 00:00:00
abstract：:Overfishing of large-bodied benthic fishes and their subsequent population collapses on the Scotian Shelf of Canada's east coast and elsewhere resulted in restructuring of entire food webs now dominated by planktivorous, forage fish species and macroinvertebrates. Despite the imposition of strict management measures i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10285
更新日期：2011-07-27 00:00:00
abstract：:Biochemical and genetic studies suggest the existence of mediators that work between the activation domains (ADs) of regulatory proteins and the basic transcriptional machinery. We have previously shown genetically that Sug1 interacts with the AD of the yeast activator Ga14. Here we provide evidence that the Sug1 prot...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/374088a0
更新日期：1995-03-02 00:00:00
abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/415599b
更新日期：2002-02-07 00:00:00
abstract：:The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/30251
更新日期：1998-05-14 00:00:00
abstract：:The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradictio...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/383350a0
更新日期：1996-09-26 00:00:00
abstract：:The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) is an essential component of the NEDD8 conjugation pathway that contro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07884
更新日期：2009-04-09 00:00:00
abstract：:The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/287686a0
更新日期：1980-10-23 00:00:00
