当前位置： SCI文献检索 > NATURE期刊下所有文献 > Curvature in metabolic scaling.

Curvature in metabolic scaling.

Abstract：

:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7), and others have found that it varies depending on factors like environment and taxonomy. Here we show that the relationship between mass and metabolic rate has convex curvature on a logarithmic scale, and is therefore not a pure power law, even after accounting for body temperature. This finding has several consequences. First, it provides an explanation for the puzzling variability in estimates of p, settling a long-standing debate. Second, it constitutes a stringent test for theories of metabolic scaling. A widely debated model based on vascular system architecture fails this test, and we suggest modifications that could bring it into compliance with the observed curvature. Third, it raises the intriguing question of whether the scaling relation limits body size.

journal_name

Nature

journal_title

Nature

authors

Kolokotrones T,Van Savage,Deeds EJ,Fontana W

doi

10.1038/nature08920

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

753-6

issue

7289

eissn

0028-0836

issn

1476-4687

pii

nature08920

journal_volume

464

pub_type

杂志文章

相关文献

NATURE文献大全
  • Author Correction: The axolotl genome and the evolution of key tissue formation regulators.

    abstract：:In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as 'D/D' rather than 'd/d' in Fig. 1a and the accompanying legend, the main text and the Methods section. The original Article has been corrected online. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-018-0141-z

    authors： Nowoshilow S,Schloissnig S,Fei JF,Dahl A,Pang AWC,Pippel M,Winkler S,Hastie AR,Young G,Roscito JG,Falcon F,Knapp D,Powell S,Cruz A,Cao H,Habermann B,Hiller M,Tanaka EM,Myers EW

    更新日期：2018-07-01 00:00:00

  • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

    abstract：:Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggest...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/363083a0

    authors： Rozakis-Adcock M,Fernley R,Wade J,Pawson T,Bowtell D

    更新日期：1993-05-06 00:00:00

  • Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes.

    abstract：:Endocytosis of the major histocompatibility complex (MHC)-encoded class I and class II molecules has been the subject of recent investigations. Class I molecules, which are key elements in T cell-mediated cytotoxicity, are differentially endocytosed by different cell types. Fibroblasts internalize their class I molecu...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/328724a0

    authors： Machy P,Truneh A,Gennaro D,Hoffstein S

    更新日期：1987-08-20 00:00:00

  • MARSIS radar sounder evidence of buried basins in the northern lowlands of Mars.

    abstract：:A hemispheric dichotomy on Mars is marked by the sharp contrast between the sparsely cratered northern lowland plains and the heavily cratered southern highlands. Mechanisms proposed to remove ancient crust or form younger lowland crust include one or more giant impacts, subcrustal transport by mantle convection, the ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature05356

    authors： Watters TR,Leuschen CJ,Plaut JJ,Picardi G,Safaeinili A,Clifford SM,Farrell WM,Ivanov AB,Phillips RJ,Stofan ER

    更新日期：2006-12-14 00:00:00

  • Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

    abstract：:Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insul...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-0942-8

    authors： Furuyama K,Chera S,van Gurp L,Oropeza D,Ghila L,Damond N,Vethe H,Paulo JA,Joosten AM,Berney T,Bosco D,Dorrell C,Grompe M,Ræder H,Roep BO,Thorel F,Herrera PL

    更新日期：2019-03-01 00:00:00

  • Body-size shifts in aquatic and terrestrial urban communities.

    abstract：:Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0140-0

    authors： Merckx T,Souffreau C,Kaiser A,Baardsen LF,Backeljau T,Bonte D,Brans KI,Cours M,Dahirel M,Debortoli N,De Wolf K,Engelen JMT,Fontaneto D,Gianuca AT,Govaert L,Hendrickx F,Higuti J,Lens L,Martens K,Matheve H,Matthysen

    更新日期：2018-06-01 00:00:00

  • Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients.

    abstract：:Stimulation of transient increases in intracellular calcium (Cai2+) activates protein kinases, regulates transcription and influences motility and morphology. Developing neurons generate spontaneous Cai2+ transients, but their role in directing neuronal differentiation and the way in which they encode information are ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/375784a0

    authors： Gu X,Spitzer NC

    更新日期：1995-06-29 00:00:00

  • Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.

    abstract：:The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08995

    authors： Sawamiphak S,Seidel S,Essmann CL,Wilkinson GA,Pitulescu ME,Acker T,Acker-Palmer A

    更新日期：2010-05-27 00:00:00

  • Cholinergic neuropil of the striatum observes striosomal boundaries.

    abstract：:Acetylcholine and dopamine are key neurotransmitters in the extrapyramidal motor system, where they are thought to lie in a 'functional balance' brought about by interactions between the terminals of the dopamine-containing nigrostriatal tract and the cholinergic interneurones of the striatum. The precise nature of th...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/323625a0

    authors： Graybiel AM,Baughman RW,Eckenstein F

    更新日期：1986-10-16 00:00:00

  • SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

    abstract：:Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12618

    authors： Shcheglovitov A,Shcheglovitova O,Yazawa M,Portmann T,Shu R,Sebastiano V,Krawisz A,Froehlich W,Bernstein JA,Hallmayer JF,Dolmetsch RE

    更新日期：2013-11-14 00:00:00

  • The cluster Terzan 5 as a remnant of a primordial building block of the Galactic bulge.

    abstract：:Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08581

    authors： Ferraro FR,Dalessandro E,Mucciarelli A,Beccari G,Rich RM,Origlia L,Lanzoni B,Rood RT,Valenti E,Bellazzini M,Ransom SM,Cocozza G

    更新日期：2009-11-26 00:00:00

  • Evidence for male allocation in pipefish?

    abstract：:Sexual differences in the extent and type of parental care lie at the heart of sexual selection theory, and evolution resulting from parental conflict has produced some striking behavioural and morphological adaptations. In a study of male pregnancy in Gulf pipefish, Paczolt and Jones showed that more eggs were transf...

    journal_title：Nature

    pub_type： 评论,杂志文章

    doi：10.1038/nature09275

    authors： Gwynne DT,Judge KA,Kelly CD

    更新日期：2010-08-26 00:00:00

  • Sensitivity of global terrestrial ecosystems to climate variability.

    abstract：:The identification of properties that contribute to the persistence and resilience of ecosystems despite climate change constitutes a research priority of global relevance. Here we present a novel, empirical approach to assess the relative sensitivity of ecosystems to climate variability, one property of resilience th...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature16986

    authors： Seddon AW,Macias-Fauria M,Long PR,Benz D,Willis KJ

    更新日期：2016-03-10 00:00:00

  • Astrocytes present myelin basic protein to encephalitogenic T-cell lines.

    abstract：:Astrocyte proliferation and perivascular lymphocyte infiltration are conspicuous among the cellular changes in the active brain lesions of multiple sclerosis patients. Recent observations have indicated that most of the perivascular lymphocytes are T cells which may be actively involved in the generation of the brain ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/307273a0

    authors： Fontana A,Fierz W,Wekerle H

    更新日期：1984-01-19 00:00:00

  • Palaeo-altimetry of the late Eocene to Miocene Lunpola basin, central Tibet.

    abstract：:The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature04506

    authors： Rowley DB,Currie BS

    更新日期：2006-02-09 00:00:00

  • Intrinsic honesty and the prevalence of rule violations across societies.

    abstract：:Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature17160

    authors： Gächter S,Schulz JF

    更新日期：2016-03-24 00:00:00

  • A new tropomyosin essential for cytokinesis in the fission yeast S. pombe.

    abstract：:Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/360084a0

    authors： Balasubramanian MK,Helfman DM,Hemmingsen SM

    更新日期：1992-11-05 00:00:00

  • Mapping GFP structure evolution during proton transfer with femtosecond Raman spectroscopy.

    abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08527

    authors： Fang C,Frontiera RR,Tran R,Mathies RA

    更新日期：2009-11-12 00:00:00

  • Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor.

    abstract：:Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population o...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12358

    authors： Peng T,Tian Y,Boogerd CJ,Lu MM,Kadzik RS,Stewart KM,Evans SM,Morrisey EE

    更新日期：2013-08-29 00:00:00

  • The crystal structure of diphtheria toxin.

    abstract：:The crystal structure of the diphtheria toxin dimer at 2.5 A resolution reveals a Y-shaped molecule of three domains. The catalytic domain, called fragment A, is of the alpha + beta type. Fragment B actually consists of two domains. The transmembrane domain consists of nine alpha-helices, two pairs of which are unusua...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/357216a0

    authors： Choe S,Bennett MJ,Fujii G,Curmi PM,Kantardjieff KA,Collier RJ,Eisenberg D

    更新日期：1992-05-21 00:00:00

  • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

    abstract：:Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/31159

    authors： Cole ST,Brosch R,Parkhill J,Garnier T,Churcher C,Harris D,Gordon SV,Eiglmeier K,Gas S,Barry CE 3rd,Tekaia F,Badcock K,Basham D,Brown D,Chillingworth T,Connor R,Davies R,Devlin K,Feltwell T,Gentles S,Hamlin N,Hol

    更新日期：1998-06-11 00:00:00

  • MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.

    abstract：:Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature14216

    authors： Boersma V,Moatti N,Segura-Bayona S,Peuscher MH,van der Torre J,Wevers BA,Orthwein A,Durocher D,Jacobs JJL

    更新日期：2015-05-28 00:00:00

  • Study of allosteric communication between protomers by immunotagging.

    abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/361749a0

    authors： Lindsley JE,Wang JC

    更新日期：1993-02-25 00:00:00

  • Human adult germline stem cells in question.

    abstract：:Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...

    journal_title：Nature

    pub_type： 评论,杂志文章

    doi：10.1038/nature09089

    authors： Ko K,Araúzo-Bravo MJ,Tapia N,Kim J,Lin Q,Bernemann C,Han DW,Gentile L,Reinhardt P,Greber B,Schneider RK,Kliesch S,Zenke M,Schöler HR

    更新日期：2010-06-24 00:00:00

  • Citrullination regulates pluripotency and histone H1 binding to chromatin.

    abstract：:Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12942

    authors： Christophorou MA,Castelo-Branco G,Halley-Stott RP,Oliveira CS,Loos R,Radzisheuskaya A,Mowen KA,Bertone P,Silva JC,Zernicka-Goetz M,Nielsen ML,Gurdon JB,Kouzarides T

    更新日期：2014-03-06 00:00:00

  • Release of gold-bearing fluids in convergent margin magmas prompted by magnetite crystallization.

    abstract：:A relationship between convergent margin magmas and copper-gold ore mineralization has long been recognized. The nature of the genetic link is controversial, particularly whether the link is due to high-oxygen-fugacity (fO2) melts and fluids released from subducted slabs or to brine exsolution during magmatic evolutio...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature02972

    authors： Sun W,Arculus RJ,Kamenetsky VS,Binns RA

    更新日期：2004-10-21 00:00:00

  • Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.

    abstract：:Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector molecules that are thought to confer antiviral defence through disruption of protein-protein interactions in the host translation-initiation machinery. However, it was recently discovered that IFITs can directly recognize vir...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11783

    authors： Abbas YM,Pichlmair A,Górna MW,Superti-Furga G,Nagar B

    更新日期：2013-02-07 00:00:00

  • Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist.

    abstract：:About one-third of human breast cancers require hormones for their continued growth and endocrine ablation or anti-hormone therapy can cause regression of these tumours. As a consequence, ovariectomy in premenopausal women or administration of an anti-oestrogen (tamoxifen) in postmenopausal women represent major optio...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/313231a0

    authors： Miller WR,Scott WN,Morris R,Fraser HM,Sharpe RM

    更新日期：1985-01-17 00:00:00

  • Structural basis for the spectral difference in luciferase bioluminescence.

    abstract：:Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light. The bioluminescence reaction, which uses luciferin, Mg-ATP and molecular oxygen to yield an electronically excited oxyluciferin species, is carried out by the enzyme luciferase. Visible light is emitted during relaxation o...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature04542

    authors： Nakatsu T,Ichiyama S,Hiratake J,Saldanha A,Kobashi N,Sakata K,Kato H

    更新日期：2006-03-16 00:00:00

  • Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells.

    abstract：:Chronic myelogenous leukaemia (CML) is a clonal disease arising from malignant transformation of pluripotent hematopoietic stem cells. In most cases, it is characterized by the presence of the Philadelphia (Ph1) chromosome (22q-) which results from a reciprocal translocation between chromosomes 9 and 22 (refs 1-3). In...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/319331a0

    authors： Kozbor D,Giallongo A,Sierzega ME,Konopka JB,Witte ON,Showe LC,Croce CM

    更新日期：1986-01-23 00:00:00