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NATURE文献大全abstract::The three-dimensional structure of the 67K amino-terminal fragment of Escherichia coli DNA topoisomerase I has been determined to 2.2 A resolution. The polypeptide folds in an unusual way to give four distinct domains enclosing a hole large enough to accommodate a double-stranded DNA. The active-site tyrosyl residue, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367138a0
更新日期:1994-01-13 00:00:00
abstract::Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in princi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10334
更新日期:2011-08-03 00:00:00
abstract::Non-small-cell lung cancer is the leading cause of cancer-related death worldwide. Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer; therefore, alternative drug targets, including epigenetic enzymes, are under consideration f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14122
更新日期:2015-04-09 00:00:00
abstract::A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/31927
更新日期:1998-04-30 00:00:00
abstract::Ecological theory suggests that large-scale patterns such as community stability can be influenced by changes in interspecific interactions that arise from the behavioural and/or physiological responses of individual species varying over time. Although this theory has experimental support, evidence from natural ecosys...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25504
更新日期:2018-02-15 00:00:00
abstract::The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/432969a
更新日期:2004-12-23 00:00:00
abstract::Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35022514
更新日期:2000-08-24 00:00:00
abstract::B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that these tumours are dependent on the RAF/MEK/ERK pathway, offered hope that inhibition of B-RAF kinase activity could benefit melanoma patients. He...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09454
更新日期:2010-09-30 00:00:00
abstract::Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09217
更新日期:2010-08-12 00:00:00
abstract::Large-conductance Ca(2+)-gated K(+) (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. This group of channels can be activated synergistically by both voltage and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09252
更新日期:2010-07-15 00:00:00
abstract::Natural visual scenes are cluttered with multiple objects whose individual features must somehow be selectively linked (or 'bound') if perception is to coincide with reality. Recent neurophysiological evidence supports a 'binding-by-synchrony' hypothesis: neurons excited by features of the same object fire synchronous...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01285
更新日期:2003-01-23 00:00:00
abstract::Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35039512
更新日期:2000-10-26 00:00:00
abstract::The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcriptio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371796a0
更新日期:1994-10-27 00:00:00
abstract::Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/430742a
更新日期:2004-08-12 00:00:00
abstract::An emerging concept in the field of cancer biology is that a rare population of 'tumour stem cells' exists among the heterogeneous group of cells that constitute a tumour. This concept, best described with human leukaemia, indicates that stem cell function (whether normal or neoplastic) might be defined by a common se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01572
更新日期:2003-05-15 00:00:00
abstract::Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades. Here we show that human JAK2 is present in the nucleus o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08448
更新日期:2009-10-08 00:00:00
abstract::DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35037509
更新日期:2000-10-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2958-5
更新日期:2020-12-01 00:00:00
abstract::El Niño events are characterized by surface warming of the tropical Pacific Ocean and weakening of equatorial trade winds that occur every few years. Such conditions are accompanied by changes in atmospheric and oceanic circulation, affecting global climate, marine and terrestrial ecosystems, fisheries and human activ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-018-0252-6
更新日期:2018-07-01 00:00:00
abstract::Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R), thus explaining the inhibitory effect of ag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/385165a0
更新日期:1997-01-09 00:00:00
abstract::Milankovitch proposed that summer insolation at mid-latitudes in the Northern Hemisphere directly causes the ice-age climate cycles. This would imply that times of ice-sheet collapse should correspond to peaks in Northern Hemisphere June insolation. But the penultimate deglaciation has proved controversial because Jun...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35003541
更新日期:2000-03-02 00:00:00
abstract::Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota1. In mammals, changes in the composition of the microbiota can influence many physiologic processes (including development, metabolism and immune cell function) and are a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1644-y
更新日期:2019-10-01 00:00:00
abstract::The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02975
更新日期:2004-10-07 00:00:00
abstract::In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43927
更新日期:1999-09-23 00:00:00
abstract::c-Abl, a non-receptor tyrosine kinase, is activated by agents that damage DNA. This activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of which are dependent on the kinase activity of c-Abl. p73, a member of the p53 family of tumour-suppressor proteins, can also induce apop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/21697
更新日期:1999-06-24 00:00:00
abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01444
更新日期:2003-02-27 00:00:00
abstract::The pseudogap is a partial gap in the electronic density of states that opens in the normal (non-superconducting) state of cuprate superconductors and whose origin is a long-standing puzzle. Its connection to the Mott insulator phase at low doping (hole concentration, p) remains ambiguous and its relation to the charg...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16983
更新日期:2016-03-10 00:00:00
abstract::The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic peptide-major histocompatibility complex (pMHC) molecules on other cells. If productive, these interactions promote the formation of an immu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08746
更新日期:2010-02-18 00:00:00
abstract::Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355441a0
更新日期:1992-01-30 00:00:00
abstract::Therizinosauroids are an enigmatic group of dinosaurs known mostly from the Cretaceous period of Asia, whose derived members are characterized by elongate necks, laterally expanded pelves, small, leaf-shaped teeth, edentulous rostra and mandibular symphyses that probably bore keratinized beaks. Although more than a do...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature03468
更新日期:2005-05-05 00:00:00