Comparative assessment of large-scale data sets of protein-protein interactions.

abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...

journal_title：Nature

authors： Dai L,Korolev KS,Gore J

更新日期：2013-04-18 00:00:00

abstract：:Splicing of the Tetrahymena ribosomal intron was first studied by Cech et al., who subsequently demonstrated that the intron RNA catalyses its own excision from a primary transcript to yield mature ribosomal RNA. This intron shares several short conserved sequences and a common secondary structure with several other i...

journal_title：Nature

authors： Szostak JW

更新日期：1986-07-03 00:00:00

abstract：:Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generati...

journal_title：Nature

authors： Abyzov A,Mariani J,Palejev D,Zhang Y,Haney MS,Tomasini L,Ferrandino AF,Rosenberg Belmaker LA,Szekely A,Wilson M,Kocabas A,Calixto NE,Grigorenko EL,Huttner A,Chawarska K,Weissman S,Urban AE,Gerstein M,Vaccarino FM

更新日期：2012-12-20 00:00:00

abstract：:The role of the cytoskeleton during viral infection is poorly understood. Here we show, using a combination of mutant and drug studies, that the intracellular enveloped form of vaccinia virus is capable of inducing the formation of actin tails that are strikingly similar to those seen in Listeria, Shigella and Rickett...

journal_title：Nature

authors： Cudmore S,Cossart P,Griffiths G,Way M

更新日期：1995-12-07 00:00:00

abstract：:Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their exhaustion during adult ...

journal_title：Nature

authors： Hock H,Hamblen MJ,Rooke HM,Schindler JW,Saleque S,Fujiwara Y,Orkin SH

更新日期：2004-10-21 00:00:00

abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...

journal_title：Nature

authors： Baleja JD,Marmorstein R,Harrison SC,Wagner G

更新日期：1992-04-02 00:00:00

abstract：:The question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs suc...

journal_title：Nature

authors： Pontieri FE,Tanda G,Orzi F,Di Chiara G

更新日期：1996-07-18 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:The crystal structure of a solid controls the interactions between the electronically active units and thus its electronic properties. In the high-temperature superconducting copper oxides, only one spatial arrangement of the electronically active Cu(2+) units-a two-dimensional square lattice-is available to study the...

journal_title：Nature

authors： Ganin AY,Takabayashi Y,Jeglic P,Arcon D,Potocnik A,Baker PJ,Ohishi Y,McDonald MT,Tzirakis MD,McLennan A,Darling GR,Takata M,Rosseinsky MJ,Prassides K

更新日期：2010-07-08 00:00:00

abstract：:Understanding how the brain constructs movements remains a fundamental challenge in neuroscience. The brain may control complex movements through flexible combination of motor primitives, where each primitive is an element of computation in the sensorimotor map that transforms desired limb trajectories into motor comm...

journal_title：Nature

authors： Thoroughman KA,Shadmehr R

更新日期：2000-10-12 00:00:00

abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

journal_title：Nature

authors： Lindsley JE,Wang JC

更新日期：1993-02-25 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00

abstract：:Fault strength is a fundamental property of seismogenic zones, and its temporal changes can increase or decrease the likelihood of failure and the ultimate triggering of seismic events. Although changes in fault strength have been suggested to explain various phenomena, such as the remote triggering of seismicity, the...

journal_title：Nature

authors： Taira T,Silver PG,Niu F,Nadeau RM

更新日期：2009-10-01 00:00:00

abstract：:To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Pla...

journal_title：Nature

authors： Beck JR,Muralidharan V,Oksman A,Goldberg DE

更新日期：2014-07-31 00:00:00

abstract：:The separation of cells into populations that do not intermix, termed compartments, is a fundamental organizing principle during development. Dorsal-ventral compartmentalization of the Drosophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor that specifies dorsal wing fat...

journal_title：Nature

authors： Rauskolb C,Correia T,Irvine KD

更新日期：1999-09-30 00:00:00

abstract：:In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article ...

journal_title：Nature

authors： Nik-Zainal S,Davies H,Staaf J,Ramakrishna M,Glodzik D,Zou X,Martincorena I,Alexandrov LB,Martin S,Wedge DC,Van Loo P,Ju YS,Smid M,Brinkman AB,Morganella S,Aure MR,Lingjærde OC,Langerød A,Ringnér M,Ahn SM,Boyault S

更新日期：2019-02-01 00:00:00

abstract：:Leukaemia inhibitory factor (LIF) has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive haematopoietic precursors and primordial germ cells. Here we show that LIF-deficient mice derived by gene targ...

journal_title：Nature

authors： Escary JL,Perreau J,Duménil D,Ezine S,Brûlet P

更新日期：1993-05-27 00:00:00

abstract：:Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and immune recognition. Among those lacking an envelope, the Picornaviridae are a large and diverse family of positive-strand RNA...

journal_title：Nature

authors： Feng Z,Hensley L,McKnight KL,Hu F,Madden V,Ping L,Jeong SH,Walker C,Lanford RE,Lemon SM

更新日期：2013-04-18 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:Surface gravity is a basic stellar property, but it is difficult to measure accurately, with typical uncertainties of 25 to 50 per cent if measured spectroscopically and 90 to 150 per cent if measured photometrically. Asteroseismology measures gravity with an uncertainty of about 2 per cent but is restricted to relati...

journal_title：Nature

authors： Bastien FA,Stassun KG,Basri G,Pepper J

更新日期：2013-08-22 00:00:00

abstract：:Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane, the intramembraneous space, or the matrix--where the protein then fun...

journal_title：Nature

authors： Bose HS,Lingappa VR,Miller WL

更新日期：2002-05-02 00:00:00

abstract：:Molecules capable of mimicking the function of a wide range of mechanical devices have been fabricated, with motors that can induce mechanical movement attracting particular attention. Such molecular motors convert light or chemical energy into directional rotary or linear motion, and are usually prepared and operated...

journal_title：Nature

authors： van Delden RA,ter Wiel MK,Pollard MM,Vicario J,Koumura N,Feringa BL

更新日期：2005-10-27 00:00:00

abstract：:The development of catalyst-controlled stereoselective olefin metathesis processes has been a pivotal recent advance in chemistry. The incorporation of appropriate ligands within complexes based on molybdenum, tungsten and ruthenium has led to reactivity and selectivity levels that were previously inaccessible. Here w...

journal_title：Nature

authors： Koh MJ,Nguyen TT,Lam JK,Torker S,Hyvl J,Schrock RR,Hoveyda AH

更新日期：2017-02-02 00:00:00

abstract：:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cy...

journal_title：Nature

authors： Kaguni JM,Fuller RS,Kornberg A

更新日期：1982-04-15 00:00:00

abstract：:Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that...

journal_title：Nature

authors： Stello D,Cantiello M,Fuller J,Huber D,García RA,Bedding TR,Bildsten L,Aguirre VS

更新日期：2016-01-21 00:00:00

abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...

journal_title：Nature

authors： Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai G

更新日期：1983-04-14 00:00:00

abstract：:Retrotransposons, which proliferate by reverse transcription of RNA intermediates, comprise a major portion of plant genomes. Plants often change the genome size and organization during evolution by rapid proliferation and deletion of long terminal repeat (LTR) retrotransposons. Precise transposon sequences throughout...

journal_title：Nature

authors： Tsukahara S,Kobayashi A,Kawabe A,Mathieu O,Miura A,Kakutani T

更新日期：2009-09-17 00:00:00

abstract：:The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development. Concomitantly, epiblast cells tran...

journal_title：Nature

authors： Shahbazi MN,Scialdone A,Skorupska N,Weberling A,Recher G,Zhu M,Jedrusik A,Devito LG,Noli L,Macaulay IC,Buecker C,Khalaf Y,Ilic D,Voet T,Marioni JC,Zernicka-Goetz M

更新日期：2017-12-14 00:00:00

abstract：:Fast radio bursts are mysterious millisecond-duration transients prevalent in the radio sky. Rapid accumulation of data in recent years has facilitated an understanding of the underlying physical mechanisms of these events. Knowledge gained from the neighbouring fields of gamma-ray bursts and radio pulsars has also of...

journal_title：Nature

authors： Zhang B

更新日期：2020-11-01 00:00:00

abstract：:Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pa...

journal_title：Nature

authors： Chien KR

更新日期：2008-05-15 00:00:00