Abstract：
:Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. They were testing the hypothesis that a mutation in the CCR5 gene, frequently found in Caucasians, may have been selected for in the past because it provided protection against (bubonic) plague; the mutation, called CCR5Delta32, is characterized by a 32-base-pair deletion. We have also tested this hypothesis by using Y. pestis infection in mice and, in addition, we have done phagocytosis experiments with macrophages from wild-type and Ccr5-deficient mice. Although, like Mecsas et al., we did not see any difference in the survival of the two groups of mice, we did find that there was a significantly reduced uptake of Y. pestis by Ccr5-deficient macrophages in vitro. Our results indicate that the role of Ccr5 in Y. pestis infection may therefore be more complex than previously thought.
journal_name
Naturejournal_title
Natureauthors
Elvin SJ,Williamson ED,Scott JC,Smith JN,Pérez De Lema G,Chilla S,Clapham P,Pfeffer K,Schlöndorff D,Luckow Bdoi
10.1038/nature02822keywords:
subject
Has Abstractpub_date
2004-07-22 00:00:00pages
417issue
6998eissn
0028-0836issn
1476-4687journal_volume
430pub_type
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