Calcium-dependent interaction of N-type calcium channels with the synaptic core complex.

abstract：:The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary and primordial processes. The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excava...

journal_title：Nature

authors： Massironi M,Simioni E,Marzari F,Cremonese G,Giacomini L,Pajola M,Jorda L,Naletto G,Lowry S,El-Maarry MR,Preusker F,Scholten F,Sierks H,Barbieri C,Lamy P,Rodrigo R,Koschny D,Rickman H,Keller HU,A'Hearn MF,Agarwal J

更新日期：2015-10-15 00:00:00

abstract：:The recent discovery of CD4(+) T cells characterized by secretion of interleukin (IL)-17 (T(H)17 cells) and the naturally occurring regulatory FOXP3(+) CD4 T cell (nT(reg)) has had a major impact on our understanding of immune processes not readily explained by the T(H)1/T(H)2 paradigm. T(H)17 and nT(reg) cells have b...

journal_title：Nature

authors： Yang L,Anderson DE,Baecher-Allan C,Hastings WD,Bettelli E,Oukka M,Kuchroo VK,Hafler DA

更新日期：2008-07-17 00:00:00

abstract：:Titan, the largest moon of Saturn, is the only satellite in the Solar System with a substantial atmosphere. The atmosphere is poorly understood and obscures the surface, leading to intense speculation about Titan's nature. Here we present observations of Titan from the imaging science experiment onboard the Cassini sp...

journal_title：Nature

authors： Porco CC,Baker E,Barbara J,Beurle K,Brahic A,Burns JA,Charnoz S,Cooper N,Dawson DD,Del Genio AD,Denk T,Dones L,Dyudina U,Evans MW,Fussner S,Giese B,Grazier K,Helfenstein P,Ingersoll AP,Jacobson RA,Johnson TV,McE

更新日期：2005-03-10 00:00:00

abstract：:A plume of water vapour escapes from fissures crossing the south polar region of the Saturnian moon Enceladus. Tidal deformation of a thin surface crust above an internal ocean could result in tensile and compressive stresses that would affect the width of the fissures; therefore, the quantity of water vapour released...

journal_title：Nature

authors： Hansen CJ,Esposito LW,Stewart AI,Meinke B,Wallis B,Colwell JE,Hendrix AR,Larsen K,Pryor W,Tian F

更新日期：2008-11-27 00:00:00

abstract：:Distrust in scientific expertise1-14 is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks2-4, as happened for measles in 20195,6. Homemade remedies7,8 and falsehoods are being shared widely on the Internet, as well as dismi...

journal_title：Nature

authors： Johnson NF,Velásquez N,Restrepo NJ,Leahy R,Gabriel N,El Oud S,Zheng M,Manrique P,Wuchty S,Lupu Y

更新日期：2020-06-01 00:00:00

abstract：:Two cytosolic fractions (A and B) from Xenopus oocytes are sufficient to support protein import into the nuclei of digitonin-permeabilized cells. Fraction A recognizes the nuclear localization sequence (NLS) and binds the import substrate to the nuclear envelope, whereas fraction B mediates the subsequent passage of t...

journal_title：Nature

authors： Moore MS,Blobel G

更新日期：1993-10-14 00:00:00

abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

journal_title：Nature

authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

更新日期：2015-02-26 00:00:00

abstract：:DNA fragments of chemically transformed and normal avian and murine cells induce transformation of NIH 3T3 mouse cells with low efficiencies. High molecular weight DNAs of cells transformed by DNA fragments induce transformation with high efficiencies in secondary transfection assays. It thus seems that endogenous tra...

journal_title：Nature

authors： Cooper GM,Okenquist S,Silverman L

更新日期：1980-04-03 00:00:00

abstract：:A major goal of molecular oncology is to identify means to kill cells lacking p53 function. Most current cancer therapy is based on damaging cellular DNA by irradiation or chemicals. Recent reports support the notion that, in the event of DNA damage, the p53 tumour-suppressor protein is able to prevent cell death by s...

journal_title：Nature

authors： Raj K,Ogston P,Beard P

更新日期：2001-08-30 00:00:00

abstract：:In the Caenorhabditis elegans hermaphrodite germ line, sperm and then oocytes are made from a common pool of germ-cell precursors. The decision to differentiate as a sperm or an oocyte is regulated by the sex-determining gene, fem-3. Expression of fem-3 in the hermaphrodite germ line directs spermatogenesis and must b...

journal_title：Nature

authors： Ahringer J,Kimble J

更新日期：1991-01-24 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:Many galaxies are thought to have supermassive black holes at their centres-more than a million times the mass of the Sun. Measurements of stellar velocities and the discovery of variable X-ray emission have provided strong evidence in favour of such a black hole at the centre of the Milky Way, but have hitherto been ...

journal_title：Nature

authors： Schödel R,Ott T,Genzel R,Hofmann R,Lehnert M,Eckart A,Mouawad N,Alexander T,Reid MJ,Lenzen R,Hartung M,Lacombe F,Rouan D,Gendron E,Rousset G,Lagrange AM,Brandner W,Ageorges N,Lidman C,Moorwood AF,Spyromilio J,Hu

更新日期：2002-10-17 00:00:00

abstract：:Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...

journal_title：Nature

authors： Pasztor VM,Bush BM

更新日期：1987-04-23 00:00:00

abstract：:Superantigens bind class II major histocompatibility proteins and stimulate powerful proliferative responses of T lymphocytes bearing particular V beta sequences as part of their alpha beta antigen receptor. Exogenous bacterial superantigens are responsible for food poisoning and toxic shock syndrome. Murine virus-enc...

journal_title：Nature

authors： Lafon M,Lafage M,Martinez-Arends A,Ramirez R,Vuillier F,Charron D,Lotteau V,Scott-Algara D

更新日期：1992-08-06 00:00:00

abstract：:Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4(CRBN) E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubi...

journal_title：Nature

authors： Matyskiela ME,Lu G,Ito T,Pagarigan B,Lu CC,Miller K,Fang W,Wang NY,Nguyen D,Houston J,Carmel G,Tran T,Riley M,Nosaka L,Lander GC,Gaidarova S,Xu S,Ruchelman AL,Handa H,Carmichael J,Daniel TO,Cathers BE,Lopez-Gi

更新日期：2016-07-14 00:00:00

abstract：:External agents of mortality (disturbances) occur over a wide range of scales of space and time, and are believed to have large effects on species diversity. The "intermediate disturbance hypothesis", which proposes maximum diversity at intermediate frequencies of disturbance, has received support from both field and ...

journal_title：Nature

authors： Buckling A,Kassen R,Bell G,Rainey PB

更新日期：2000-12-21 00:00:00

abstract：:The coupling of ATP hydrolysis to electron transfer by the enzyme nitrogenase during biological nitrogen fixation is an important example of a nucleotide-dependent transduction mechanism. The crystal structure has been determined for the complex between the Fe-protein and MoFe-protein components of nitrogenase stabili...

journal_title：Nature

authors： Schindelin H,Kisker C,Schlessman JL,Howard JB,Rees DC

更新日期：1997-05-22 00:00:00

abstract：:Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome ...

journal_title：Nature

authors： Maskell DP,Renault L,Serrao E,Lesbats P,Matadeen R,Hare S,Lindemann D,Engelman AN,Costa A,Cherepanov P

更新日期：2015-07-16 00:00:00

abstract：:Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imagin...

journal_title：Nature

authors： Ellis SJ,Gomez NC,Levorse J,Mertz AF,Ge Y,Fuchs E

更新日期：2019-05-01 00:00:00

abstract：:Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...

journal_title：Nature

authors： Elwood PC,Gallacher JE,Phillips KM,Davies BE,Toothill C

更新日期：1984-07-12 00:00:00

abstract：:Sleep has been assumed to be necessary for development and to be a vital function in mammals and other animals. However, Lyamin et al. claim that in bottlenose dolphins (Tursiops truncatus) and killer whales (Orcinus orca), neonates and their mothers show almost no sleep behaviour for the first month after birth; this...

journal_title：Nature

authors： Sekiguchi Y,Arai K,Kohshima S

更新日期：2006-06-22 00:00:00

abstract：:Rapid warming over the past 50 years on the Antarctic Peninsula is associated with the collapse of a number of ice shelves and accelerating glacier mass loss. In contrast, warming has been comparatively modest over West Antarctica and significant changes have not been observed over most of East Antarctica, suggesting ...

journal_title：Nature

authors： Mulvaney R,Abram NJ,Hindmarsh RC,Arrowsmith C,Fleet L,Triest J,Sime LC,Alemany O,Foord S

更新日期：2012-09-06 00:00:00

abstract：:The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conser...

journal_title：Nature

authors： Hrvatin S,Sun S,Wilcox OF,Yao H,Lavin-Peter AJ,Cicconet M,Assad EG,Palmer ME,Aronson S,Banks AS,Griffith EC,Greenberg ME

更新日期：2020-07-01 00:00:00

abstract：:We have obtained evidence that poliovirus and other picornavirus particles are specifically modified by having myristic acid covalently bound to a capsid protein. The electron density map of poliovirus confirms the position of the myristate molecule and defines its location in the virus particle. Analogies with other ...

journal_title：Nature

authors： Chow M,Newman JF,Filman D,Hogle JM,Rowlands DJ,Brown F

更新日期：1987-06-11 00:00:00

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00

abstract：:Some beetles in the Namib Desert collect drinking water from fog-laden wind on their backs. We show here that these large droplets form by virtue of the insect's bumpy surface, which consists of alternating hydrophobic, wax-coated and hydrophilic, non-waxy regions. The design of this fog-collecting structure can be re...

journal_title：Nature

authors： Parker AR,Lawrence CR

更新日期：2001-11-01 00:00:00

abstract：:The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...

journal_title：Nature

authors： Dial OE,Ashoori RC,Pfeiffer LN,West KW

更新日期：2010-03-25 00:00:00

abstract：:The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs). Because eukaryotic BATs...

journal_title：Nature

authors： Wang H,Goehring A,Wang KH,Penmatsa A,Ressler R,Gouaux E

更新日期：2013-11-07 00:00:00

abstract：:The ability to confine and store optical energy in small volumes has implications in fields ranging from cavity quantum electrodynamics to photonics. Of all cavity geometries, micrometre-sized dielectric spherical resonators are the best in terms of their ability to store energy for long periods of time within small v...

journal_title：Nature

authors： Spillane SM,Kippenberg TJ,Vahala KJ

更新日期：2002-02-07 00:00:00

abstract：:With the world's focus on reducing our dependency on fossil-fuel energy, the scientific community can investigate new plastic materials that are much less dependent on petroleum than are conventional plastics. Given increasing environmental issues, the idea of replacing plastics with water-based gels, so-called hydrog...

journal_title：Nature

authors： Wang Q,Mynar JL,Yoshida M,Lee E,Lee M,Okuro K,Kinbara K,Aida T

更新日期：2010-01-21 00:00:00