A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

abstract：:Large, actively swimming suspension feeders evolved several times in Earth's history, arising independently from groups as diverse as sharks, rays and stem teleost fishes, and in mysticete whales. However, animals occupying this niche have not been identified from the early Palaeozoic era. Anomalocarids, a group of st...

journal_title：Nature

authors： Vinther J,Stein M,Longrich NR,Harper DA

更新日期：2014-03-27 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:The use of viscid silk in aerial webs as a means to capture prey was a key innovation of araneoid spiders and has contributed largely to their ecological success. Here I describe a single silk thread from a spider's web that bears glue droplets and has been preserved in Lebanese amber from the Early Cretaceous period ...

journal_title：Nature

authors： Zschokke S

更新日期：2003-08-07 00:00:00

abstract：:The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...

journal_title：Nature

authors： Tanaka I,Appelt K,Dijk J,White SW,Wilson KS

更新日期：1984-08-02 00:00:00

abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

journal_title：Nature

authors： Massol F,Crochet PA

更新日期：2008-02-28 00:00:00

abstract：:The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K isoforms in organismal physiology and disease are unknown. To delineate the role of p110alpha, a ubiquitously expressed PI(3)...

journal_title：Nature

authors： Foukas LC,Claret M,Pearce W,Okkenhaug K,Meek S,Peskett E,Sancho S,Smith AJ,Withers DJ,Vanhaesebroeck B

更新日期：2006-05-18 00:00:00

abstract：:The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the f...

journal_title：Nature

authors： Hilf RJ,Dutzler R

更新日期：2009-01-01 00:00:00

abstract：:By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microe...

journal_title：Nature

authors： Minn AJ,Gupta GP,Siegel PM,Bos PD,Shu W,Giri DD,Viale A,Olshen AB,Gerald WL,Massagué J

更新日期：2005-07-28 00:00:00

abstract：:A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...

journal_title：Nature

authors： Kanamori H,Press F

更新日期：1970-04-25 00:00:00

abstract：:Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...

journal_title：Nature

authors： Gabbiani F,Krapp HG,Koch C,Laurent G

更新日期：2002-11-21 00:00:00

abstract：:Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia. For over half a century, this agent has been prescribed to patients wit...

journal_title：Nature

authors： Madiraju AK,Erion DM,Rahimi Y,Zhang XM,Braddock DT,Albright RA,Prigaro BJ,Wood JL,Bhanot S,MacDonald MJ,Jurczak MJ,Camporez JP,Lee HY,Cline GW,Samuel VT,Kibbey RG,Shulman GI

更新日期：2014-06-26 00:00:00

abstract：:Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...

journal_title：Nature

authors： Meyer ET,Georganopoulos M,Sparks WB,Perlman E,van der Marel RP,Anderson J,Sohn ST,Biretta J,Norman C,Chiaberge M

更新日期：2015-05-28 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis an...

journal_title：Nature

authors： Herndon LA,Schmeissner PJ,Dudaronek JM,Brown PA,Listner KM,Sakano Y,Paupard MC,Hall DH,Driscoll M

更新日期：2002-10-24 00:00:00

abstract：:The National Institutes of Health's Recombinant DNA Advisory Committee (RAC) has approved a commercial proposal by Advanced Genetic Sciences Inc. to field-test recombinant ice-nucleating bacteria. Its decision came two weeks after a federal judge halted a similar trial by researchers from the University of California...

journal_title：Nature

authors： Budiansky S

更新日期：1984-06-07 00:00:00

abstract：:The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral-facial tumour obstructs the animal's ability to feed. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal stu...

journal_title：Nature

authors： Pearse AM,Swift K

更新日期：2006-02-02 00:00:00

abstract：:Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...

journal_title：Nature

authors： Krashes MJ,Shah BP,Madara JC,Olson DP,Strochlic DE,Garfield AS,Vong L,Pei H,Watabe-Uchida M,Uchida N,Liberles SD,Lowell BB

更新日期：2014-03-13 00:00:00

abstract：:A hemispheric dichotomy on Mars is marked by the sharp contrast between the sparsely cratered northern lowland plains and the heavily cratered southern highlands. Mechanisms proposed to remove ancient crust or form younger lowland crust include one or more giant impacts, subcrustal transport by mantle convection, the ...

journal_title：Nature

authors： Watters TR,Leuschen CJ,Plaut JJ,Picardi G,Safaeinili A,Clifford SM,Farrell WM,Ivanov AB,Phillips RJ,Stofan ER

更新日期：2006-12-14 00:00:00

abstract：:The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity. Here we describe a method-influence mapping-that uses single-neuron perturbations to directly measure how cortical neurons reshape sensory represent...

journal_title：Nature

authors： Chettih SN,Harvey CD

更新日期：2019-03-01 00:00:00

abstract：:UV light is a potent mutagen in most living cells, but molecular analysis of its mode of action in animal cells has not been possible because of the high complexity of the cell genome. Therefore, we have used simian virus 40 (SV40) as a biological probe to study the mutagenic effect of UV-irradiation at the molecular ...

journal_title：Nature

authors： Bourre F,Sarasin A

更新日期：1983-09-01 00:00:00

abstract：:The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...

journal_title：Nature

authors： Green R,Ellington AD,Szostak JW

更新日期：1990-09-27 00:00:00

abstract：:Individual mammals have the capacity to express at least one million distinct antigen binding specificities, implying a high degree of structural heterogeneity in the variable heavy and light chain (VH and VL) portions of the antibody molecules. Studies of higher vertebrate species suggest that this heterogeneity is c...

journal_title：Nature

authors： Mäkelä O,Litman GW

更新日期：1980-10-16 00:00:00

abstract：:The promoters of eukaryotic genes are being increasingly defined through the identification of consensus DNA sequences, by mutational analysis, and by in vitro and in vivo studies of transcription. Whereas the TATA sequence (Goldberg-Hogness box) has been largely conserved among protein encoding genes (transcribed by ...

journal_title：Nature

authors： Russell PR

更新日期：1983-01-13 00:00:00

abstract：:The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the ...

journal_title：Nature

authors： Braig K,Otwinowski Z,Hegde R,Boisvert DC,Joachimiak A,Horwich AL,Sigler PB

更新日期：1994-10-13 00:00:00

abstract：:ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

journal_title：Nature

authors： Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

更新日期：2014-06-12 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:T cells recognize foreign proteins as peptides bound to self molecules encoded by the major histocompatibility complex (MHC). The kinetics of interaction between purified class II MHC molecules and peptides is unusual, in that the rate of association is very slow, but once formed, the complexes are extremely stable. T...

journal_title：Nature

authors： Adorini L,Appella E,Doria G,Cardinaux F,Nagy ZA

更新日期：1989-12-14 00:00:00

abstract：:A fundamental tenet of classical mendelian genetics is that allelic information is stably inherited from one generation to the next, resulting in predictable segregation patterns of differing alleles. Although several exceptions to this principle are known, all represent specialized cases that are mechanistically rest...

journal_title：Nature

authors： Lolle SJ,Victor JL,Young JM,Pruitt RE

更新日期：2005-03-24 00:00:00

abstract：:Topological physics relies on the structure of the eigenstates of the Hamiltonians. The geometry of the eigenstates is encoded in the quantum geometric tensor1-comprising the Berry curvature2 (crucial for topological matter)3 and the quantum metric4, which defines the distance between the eigenstates. Knowledge of the...

journal_title：Nature

authors： Gianfrate A,Bleu O,Dominici L,Ardizzone V,De Giorgi M,Ballarini D,Lerario G,West KW,Pfeiffer LN,Solnyshkov DD,Sanvitto D,Malpuech G

更新日期：2020-02-01 00:00:00

abstract：:In Fig. 3d this Letter, the R2 value should have been '0.19' instead of '0.66'; this has been corrected online. ...

journal_title：Nature

authors： Hoyt JR,Langwig KE,White JP,Kaarakka HM,Redell JA,Kurta A,DePue JE,Scullon WH,Parise KL,Foster JT,Frick WF,Kilpatrick AM

更新日期：2019-02-01 00:00:00