Measurement of the quantum geometric tensor and of the anomalous Hall drift.

abstract：:Interest in attributing the risk of damaging weather-related events to anthropogenic climate change is increasing. Yet climate models used to study the attribution problem typically do not resolve the weather systems associated with damaging events such as the UK floods of October and November 2000. Occurring during t...

journal_title：Nature

authors： Pall P,Aina T,Stone DA,Stott PA,Nozawa T,Hilberts AG,Lohmann D,Allen MR

更新日期：2011-02-17 00:00:00

abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...

journal_title：Nature

authors： Kupperman E,An S,Osborne N,Waldron S,Stainier DY

更新日期：2000-07-13 00:00:00

abstract：:Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...

journal_title：Nature

authors： Akyuz N,Altman RB,Blanchard SC,Boudker O

更新日期：2013-10-03 00:00:00

abstract：:Protein modification by the conjugation of ubiquitin moieties--ubiquitination--plays a major part in many biological processes, including cell cycle and apoptosis. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiqui...

journal_title：Nature

authors： Brummelkamp TR,Nijman SM,Dirac AM,Bernards R

更新日期：2003-08-14 00:00:00

abstract：:The realization of superfluidity in a dilute gas of fermionic atoms, analogous to superconductivity in metals, represents a long-standing goal of ultracold gas research. In such a fermionic superfluid, it should be possible to adjust the interaction strength and tune the system continuously between two limits: a Barde...

journal_title：Nature

authors： Greiner M,Regal CA,Jin DS

更新日期：2003-12-04 00:00:00

abstract：:A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...

journal_title：Nature

authors： Engel MH,Macko SA,Silfer JA

更新日期：1990-11-01 00:00:00

abstract：:The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, b...

journal_title：Nature

authors： Kuhn A,Wickner W,Kreil G

更新日期：1986-07-24 00:00:00

abstract：:The vasa gene product of Drosophila melanogaster is required only in the female germ line. Progeny of females homozygous for vasa mutations lack posterior structures and pole cells. Isolation and characterization of vasa genomic and complementary DNA clones show that the transcript is abundant in the female germ line ...

journal_title：Nature

authors： Lasko PF,Ashburner M

更新日期：1988-10-13 00:00:00

abstract：:Molecular processes that govern pathogenic features of erythrocyte invasion and cytoadherence in malaria are reliant on Plasmodium-specific Duffy-binding-like domains (DBLs). These cysteine-rich modules recognize diverse host cell-surface receptors during pathogenesis. DBLs of parasite erythrocyte-binding proteins med...

journal_title：Nature

authors： Singh SK,Hora R,Belrhali H,Chitnis CE,Sharma A

更新日期：2006-02-09 00:00:00

abstract：:The sensation of pain is carried to the central nervous system by small-diameter fibres which terminate in the superficial layers of the spinal grey matter, particularly the substantia gelatinosa. Opiate drugs administered into the substantia gelatinosa inhibit the excitation of deeper dorsal horn neurones by noxious ...

journal_title：Nature

authors： Yoshimura M,North RA

更新日期：1983-10-06 00:00:00

abstract：:Close inbreeding is known for a variety of small mammal species for which a high probability of mortality during dispersal makes helping and delayed maturation a relatively secure fitness option. Prolonged inbreeding, however, is usually associated with lowered fitness, and it has been shown that most highly inbred sm...

journal_title：Nature

authors： O'Riain MJ,Jarvis JU,Faulkes CG

更新日期：1996-04-18 00:00:00

abstract：:Lung epithelial cells can influence immune responses to airway allergens. Airway epithelial cells also undergo apoptosis after encountering environmental allergens; yet, relatively little is known about how these are cleared, and their effect on airway inflammation. Here we show that airway epithelial cells efficientl...

journal_title：Nature

authors： Juncadella IJ,Kadl A,Sharma AK,Shim YM,Hochreiter-Hufford A,Borish L,Ravichandran KS

更新日期：2013-01-24 00:00:00

abstract：:Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...

journal_title：Nature

authors： Krogsgaard M,Li QJ,Sumen C,Huppa JB,Huse M,Davis MM

更新日期：2005-03-10 00:00:00

abstract：:Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...

journal_title：Nature

authors： Takamatsu H,Iso K

更新日期：1982-08-26 00:00:00

abstract：:Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands. However, coupled replication presents a largely unrecognized topological problem. Because DNA polymerase must travel a helical path during synthesis, the physical connection between leading- ...

journal_title：Nature

authors： Kurth I,Georgescu RE,O'Donnell ME

更新日期：2013-04-04 00:00:00

abstract：:Ubiquitin (Ub) has important roles in a wide range of intracellular signalling pathways. In the conventional view, ubiquitin alters the signalling activity of the target protein through covalent modification, but accumulating evidence points to the emerging role of non-covalent interaction between ubiquitin and the ta...

journal_title：Nature

authors： Peisley A,Wu B,Xu H,Chen ZJ,Hur S

更新日期：2014-05-01 00:00:00

abstract：:During embryogenesis, body pattern is established in a stepwise process. After specification of the body axis, the embryo is subdivided into smaller units. Within these units, a diverse array of cell types is then generated. The subdivisions of the Drosophila embryo, called parasegments, are defined by the interface b...

journal_title：Nature

authors： Dougan S,DiNardo S

更新日期：1992-11-26 00:00:00

abstract：:Single-stranded DNA can fold into well-defined sequence-dependent tertiary structures that specifically bind a variety of target molecules, raising the possibility that some folded single-stranded DNAs might exhibit catalytic activities similar to those of ribozymes and protein enzymes. Derivatives of the hammerhead r...

journal_title：Nature

authors： Cuenoud B,Szostak JW

更新日期：1995-06-15 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrob...

journal_title：Nature

authors： Lande R,Gregorio J,Facchinetti V,Chatterjee B,Wang YH,Homey B,Cao W,Wang YH,Su B,Nestle FO,Zal T,Mellman I,Schröder JM,Liu YJ,Gilliet M

更新日期：2007-10-04 00:00:00

abstract：:Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...

journal_title：Nature

authors： Gilmore CK,McCarthy SE,Spelke ES

更新日期：2007-05-31 00:00:00

abstract：:Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senesc...

journal_title：Nature

authors： Yu GL,Bradley JD,Attardi LD,Blackburn EH

更新日期：1990-03-08 00:00:00

abstract：:The origin of tetrapods from their fish antecedents, approximately 400 million years ago, was coupled with the origin of terrestrial locomotion and the evolution of supporting limbs. Polypterus is a member of the basal-most group of ray-finned fish (actinopterygians) and has many plesiomorphic morphologies that are co...

journal_title：Nature

authors： Standen EM,Du TY,Larsson HC

更新日期：2014-09-04 00:00:00

abstract：:In the present-day climate, surface water salinities are low in the western tropical Pacific Ocean and increase towards the eastern part of the basin. The salinity of surface waters in the tropical Pacific Ocean is thought to be controlled by a combination of atmospheric convection, precipitation, evaporation and ocea...

journal_title：Nature

authors： Stott L,Cannariato K,Thunell R,Haug GH,Koutavas A,Lund S

更新日期：2004-09-02 00:00:00

abstract：:Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...

journal_title：Nature

authors： Paton JJ,Belova MA,Morrison SE,Salzman CD

更新日期：2006-02-16 00:00:00

abstract：:Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases. This response property has led to a hypothesis that dopamine neurons encode value-related signals and are inhibited by aversive events. Here we show that this is tr...

journal_title：Nature

authors： Matsumoto M,Hikosaka O

更新日期：2009-06-11 00:00:00

abstract：:Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...

journal_title：Nature

authors： Rowan R

更新日期：2004-08-12 00:00:00

abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...

journal_title：Nature

authors： Brockmann M,Blomen VA,Nieuwenhuis J,Stickel E,Raaben M,Bleijerveld OB,Altelaar AFM,Jae LT,Brummelkamp TR

更新日期：2017-06-08 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:Phototransduction in invertebrate microvillar photoreceptors is thought to be mediated by the activation of phospholipase C (PLC), but how this leads to gating of the light-sensitive channels is unknown. Most attention has focused on inositol-1,4,5-trisphosphate, a second messenger produced by PLC from phosphatidylino...

journal_title：Nature

authors： Chyb S,Raghu P,Hardie RC

更新日期：1999-01-21 00:00:00

abstract：:Troponin is essential in Ca(2+) regulation of skeletal and cardiac muscle contraction. It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament. Here we present crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardia...

journal_title：Nature

authors： Takeda S,Yamashita A,Maeda K,Maéda Y

更新日期：2003-07-03 00:00:00