Abstract:
:Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for telomerase in vivo.
journal_name
Naturejournal_title
Natureauthors
Yu GL,Bradley JD,Attardi LD,Blackburn EHdoi
10.1038/344126a0subject
Has Abstractpub_date
1990-03-08 00:00:00pages
126-32issue
6262eissn
0028-0836issn
1476-4687journal_volume
344pub_type
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