Abstract:
:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intracellular recordings indicating that excitatory inputs themselves are orientation-selective, so inhibition may not contribute to the observed selectivity. Also, there is controversy about the presence of intracortical horizontal connections mediating inhibition for selectivity and about the theoretical validity of such inhibitory connections. Using cross-correlation analysis of the activities of two neurons recorded simultaneously, we find that inhibitory interactions exist between cells with somewhat different, but not orthogonal, orientation preferences. This suggests that intracortical horizontal inhibition operates between 'orientation columns' to sharpen the orientation tuning of cortical neurons.
journal_name
Naturejournal_title
Natureauthors
Hata Y,Tsumoto T,Sato H,Hagihara K,Tamura Hdoi
10.1038/335815a0subject
Has Abstractpub_date
1988-10-27 00:00:00pages
815-7issue
6193eissn
0028-0836issn
1476-4687journal_volume
335pub_type
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