The neural basis of Drosophila gravity-sensing and hearing.

abstract：:Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range ...

journal_title：Nature

authors： Ponder BA

更新日期：2001-05-17 00:00:00

abstract：:Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...

journal_title：Nature

authors： Elwood PC,Gallacher JE,Phillips KM,Davies BE,Toothill C

更新日期：1984-07-12 00:00:00

abstract：:Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...

journal_title：Nature

authors： de Godoy LM,Olsen JV,Cox J,Nielsen ML,Hubner NC,Fröhlich F,Walther TC,Mann M

更新日期：2008-10-30 00:00:00

abstract：:MicroRNAs (miRNAs) mediate post-transcriptional gene regulation through association with Argonaute proteins (AGOs). Crystal structures of archaeal and bacterial homologues of AGOs have shown that the MID (middle) domain mediates the interaction with the phosphorylated 5' end of the miRNA guide strand and this interact...

journal_title：Nature

authors： Frank F,Sonenberg N,Nagar B

更新日期：2010-06-10 00:00:00

abstract：:Photosystem II is the site of photosynthetic water oxidation and contains 20 subunits with a total molecular mass of 350 kDa. The structure of photosystem II has been reported at resolutions from 3.8 to 2.9 Å. These resolutions have provided much information on the arrangement of protein subunits and cofactors but are...

journal_title：Nature

authors： Umena Y,Kawakami K,Shen JR,Kamiya N

更新日期：2011-05-05 00:00:00

abstract：:The availability of iron limits primary productivity and the associated uptake of carbon over large areas of the ocean. Iron thus plays an important role in the carbon cycle, and changes in its supply to the surface ocean may have had a significant effect on atmospheric carbon dioxide concentrations over glacial-inter...

journal_title：Nature

authors： Blain S,Quéguiner B,Armand L,Belviso S,Bombled B,Bopp L,Bowie A,Brunet C,Brussaard C,Carlotti F,Christaki U,Corbière A,Durand I,Ebersbach F,Fuda JL,Garcia N,Gerringa L,Griffiths B,Guigue C,Guillerm C,Jacquet S,J

更新日期：2007-04-26 00:00:00

abstract：:Fault strength is a fundamental property of seismogenic zones, and its temporal changes can increase or decrease the likelihood of failure and the ultimate triggering of seismic events. Although changes in fault strength have been suggested to explain various phenomena, such as the remote triggering of seismicity, the...

journal_title：Nature

authors： Taira T,Silver PG,Niu F,Nadeau RM

更新日期：2009-10-01 00:00:00

abstract：:Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the co...

journal_title：Nature

authors： Gandon S,Mackinnon MJ,Nee S,Read AF

更新日期：2001-12-13 00:00:00

abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...

journal_title：Nature

authors： Brockmann M,Blomen VA,Nieuwenhuis J,Stickel E,Raaben M,Bleijerveld OB,Altelaar AFM,Jae LT,Brummelkamp TR

更新日期：2017-06-08 00:00:00

abstract：:If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5' to 3' fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA...

journal_title：Nature

authors： Niu H,Chung WH,Zhu Z,Kwon Y,Zhao W,Chi P,Prakash R,Seong C,Liu D,Lu L,Ira G,Sung P

更新日期：2010-09-02 00:00:00

abstract：:Hypogonadism in the mutant hpg mouse is characterized by a deficiency of hypothalamic gonadotropin releasing hormone (GnRH). Affected male mice exhibit immature reproductive organs, small abdominal testes and low pituitary and plasma gonadotropin concentrations. Recent studies have demonstrated the potential of fetal ...

journal_title：Nature

authors： Krieger DT,Perlow MJ,Gibson MJ,Davies TF,Zimmerman EA,Ferin M,Charlton HM

更新日期：1982-07-29 00:00:00

abstract：:During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by pr...

journal_title：Nature

authors： Scheele CL,Hannezo E,Muraro MJ,Zomer A,Langedijk NS,van Oudenaarden A,Simons BD,van Rheenen J

更新日期：2017-02-16 00:00:00

abstract：:Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the associat...

journal_title：Nature

authors： Lu H,Zawel L,Fisher L,Egly JM,Reinberg D

更新日期：1992-08-20 00:00:00

abstract：:A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived fr...

journal_title：Nature

authors： Leung DW,Spencer SA,Cachianes G,Hammonds RG,Collins C,Henzel WJ,Barnard R,Waters MJ,Wood WI

更新日期：1987-12-10 00:00:00

abstract：:X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the androgen receptor gene on the proximal long arm of the X chromosome is a candidate gene for this disease. In p...

journal_title：Nature

authors： La Spada AR,Wilson EM,Lubahn DB,Harding AE,Fischbeck KH

更新日期：1991-07-04 00:00:00

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...

journal_title：Nature

authors： van Leyen K,Duvoisin RM,Engelhardt H,Wiedmann M

更新日期：1998-09-24 00:00:00

abstract：:Below water depths of about 300 metres, pressure and temperature conditions cause methane to form ice-like crystals of methane hydrate. Marine deposits of methane hydrate are estimated to be large, amassing about 10,000 gigatonnes of carbon, and are thought to be important to global change and seafloor stability, as w...

journal_title：Nature

authors： Wood WT,Gettrust JF,Chapman NR,Spence GD,Hyndman RD

更新日期：2002-12-12 00:00:00

abstract：:The nuclear envelope defines a compartment boundary which is penetrated by pores that mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while processed messenger RNA, transfer RNA and ribosomal subunits are transported to the cytoplasm. Proteins destined for the nucleus become localiz...

journal_title：Nature

authors： Goldfarb DS,Gariépy J,Schoolnik G,Kornberg RD

更新日期：1986-08-14 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, the process of conjugation of haploid cells of genotype MATa and MAT alpha to form MATa/alpha diploids is triggered by pheromones produced by each mating type. These pheromones stimulate a cellular response by interaction with receptors linked to a heterotrimeric G protei...

journal_title：Nature

authors： Simon MN,De Virgilio C,Souza B,Pringle JR,Abo A,Reed SI

更新日期：1995-08-24 00:00:00

abstract：:Class-V myosin proceeds along actin filaments with large ( approximately 36 nm) steps. Myosin-V has two heads, each of which consists of a motor domain and a long (23 nm) neck domain. In accordance with the widely accepted lever-arm model, it was suggested that myosin-V steps to successive (36 nm) target zones along t...

journal_title：Nature

authors： Tanaka H,Homma K,Iwane AH,Katayama E,Ikebe R,Saito J,Yanagida T,Ikebe M

更新日期：2002-01-10 00:00:00

abstract：:Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both ...

journal_title：Nature

authors： De Robertis EM,Sasai Y

更新日期：1996-03-07 00:00:00

abstract：:The carotid body type I cell contains amines and has features, both morphological and cytochemical, which indicate that it may also produce a peptide. Many regulatory peptides are now known to be present in both central and peripheral tissues. In the periphery these neuropeptides occur in both classical endocrine (APU...

journal_title：Nature

authors： Wharton J,Polak JM,Pearse AG,McGregor GP,Bryant MG,Bloom SR,Emson PC,Bisgard GE,Will JA

更新日期：1980-03-20 00:00:00

abstract：:In the cores of some clusters of galaxies the hot intracluster plasma is dense enough that it should cool radiatively in the cluster's lifetime, leading to continuous 'cooling flows' of gas sinking towards the cluster centre, yet no such cooling flow has been observed. The low observed star-formation rates and cool ga...

journal_title：Nature

authors： McDonald M,Bayliss M,Benson BA,Foley RJ,Ruel J,Sullivan P,Veilleux S,Aird KA,Ashby ML,Bautz M,Bazin G,Bleem LE,Brodwin M,Carlstrom JE,Chang CL,Cho HM,Clocchiatti A,Crawford TM,Crites AT,de Haan T,Desai S,Dobbs M

更新日期：2012-08-16 00:00:00

abstract：:Metastasis is a major cause of death in cancer patients and involves a multistep process including detachment of cancer cells from a primary cancer, invasion of surrounding tissue, spread through circulation, re-invasion and proliferation in distant organs. KiSS-1 is a human metastasis suppressor gene, that suppresses...

journal_title：Nature

authors： Ohtaki T,Shintani Y,Honda S,Matsumoto H,Hori A,Kanehashi K,Terao Y,Kumano S,Takatsu Y,Masuda Y,Ishibashi Y,Watanabe T,Asada M,Yamada T,Suenaga M,Kitada C,Usuki S,Kurokawa T,Onda H,Nishimura O,Fujino M

更新日期：2001-05-31 00:00:00

abstract：:High biodiversity has been shown to enhance ecological stability on small spatial scales and over intervals of weeks to decades. It remains unclear, however, whether this diversity-stability relationship can be scaled up to regional scales, or to longer timescales. Without empirical validation at larger scales, the im...

journal_title：Nature

authors： Kiessling W

更新日期：2005-01-27 00:00:00

abstract：:Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...

journal_title：Nature

authors： Moxham CM,Malbon CC

更新日期：1996-02-29 00:00:00

abstract：:IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...

journal_title：Nature

authors： Sutton BJ,Gould HJ

更新日期：1993-12-02 00:00:00

abstract：:The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds...

journal_title：Nature

authors： Steiner JP,Dawson TM,Fotuhi M,Glatt CE,Snowman AM,Cohen N,Snyder SH

更新日期：1992-08-13 00:00:00

abstract：:The difficulty of working with the intact brain in vivo has led to the increasing use of nerve cell cultures in neurobiology. However, dissociated cells cannot be unambiguously identified by morphological criteria before the third week in culture, for it is not until then that the basic morphology and size of neurones...

journal_title：Nature

authors： Hooghe-Peters EL,Fowlkes BJ,Hooghe RJ

更新日期：1979-10-04 00:00:00