Abstract:
:A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
journal_name
Naturejournal_title
Natureauthors
Leung DW,Spencer SA,Cachianes G,Hammonds RG,Collins C,Henzel WJ,Barnard R,Waters MJ,Wood WIdoi
10.1038/330537a0subject
Has Abstractpub_date
1987-12-10 00:00:00pages
537-43issue
6148eissn
0028-0836issn
1476-4687journal_volume
330pub_type
杂志文章相关文献
NATURE文献大全abstract::Memory formation is a multi-stage process that initially requires cellular consolidation in the hippocampus, after which memories are downloaded to the cortex for maintenance, in a process termed systems consolidation. Epigenetic mechanisms regulate both types of consolidation, but histone variant exchange, in which c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13707
更新日期:2014-11-27 00:00:00
abstract::Water has many kinetic and thermodynamic properties that exhibit an anomalous dependence on temperature, in particular in the supercooled phase. These anomalies have long been interpreted in terms of underlying structural causes, and their experimental characterization points to the existence of a singularity at a tem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02409
更新日期:2004-03-18 00:00:00
abstract::Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298819a0
更新日期:1982-08-26 00:00:00
abstract::The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fusions. Using next-generatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14157
更新日期:2015-02-12 00:00:00
abstract::The activation of T cells through interaction of their T-cell receptors with antigenic peptide bound to major histocompatibility complex (MHC) on the surface of antigen presenting cells (APCs) is a crucial step in adaptive immunity. Here we use three-dimensional fluorescence microscopy to visualize individual peptide-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01076
更新日期:2002-10-24 00:00:00
abstract::The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11092
更新日期:2012-05-30 00:00:00
abstract::Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes that mediate glycosaminoglycan biosynthesis have severe consequences in Drosophila and mice. Mutations in the Drosophila gene sugarless, which ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01635
更新日期:2003-05-22 00:00:00
abstract::Fusion of myeloma cells and B lymphocytes to form hybridomas which produce monoclonal antibodies has been a major advance, but the poor efficiency and randomness of viral or polyethylene glycol fusion techniques generally gives poor yields of specific, high affinity antibodies. High voltage electrical fields with diel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310792a0
更新日期:1984-08-30 00:00:00
abstract::The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381620a0
更新日期:1996-06-13 00:00:00
abstract::The sensation of pain is carried to the central nervous system by small-diameter fibres which terminate in the superficial layers of the spinal grey matter, particularly the substantia gelatinosa. Opiate drugs administered into the substantia gelatinosa inhibit the excitation of deeper dorsal horn neurones by noxious ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305529a0
更新日期:1983-10-06 00:00:00
abstract::Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target their cargo to the central translocation channel, where phenylalanine-glycine-rich repeats serve as binding sites. The s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06170
更新日期:2007-10-04 00:00:00
abstract::Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale identification of proteins and their post-translational modifications; (2) 'differ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35015709
更新日期:2000-06-15 00:00:00
abstract::THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo. It is expressed at the blastocyst stage of development, and accumulates to high levels in tissues of endodermal and mesodermal origin (H. Kim, unpublished result). After birth the gene is expressed in all tissues except skeletal m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351153a0
更新日期:1991-05-09 00:00:00
abstract::Contamination of ground waters with water-soluble aromatic hydrocarbons, common components of petroleum pollution, often produces anoxic conditions under which microbial degradation of the aromatics is slow. Oxygen is often added to contaminated ground water to stimulate biodegradation, but this can be technically dif...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370128a0
更新日期:1994-07-14 00:00:00
abstract::The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0593-1
更新日期:2018-10-01 00:00:00
abstract::Crustal faults have long been identified as sites where localized sliding motion occurs during earthquakes, which allows for the relative motion between adjacent crustal blocks. Although there is a growing awareness that we must understand the evolution of fault systems on many timescales to relate present-day crustal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01354
更新日期:2003-01-30 00:00:00
abstract::Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorph...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322173a0
更新日期:1986-07-10 00:00:00
abstract::The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions. The gene for protein S has been cloned and the DNA se...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315771a0
更新日期:1985-06-27 00:00:00
abstract::Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335815a0
更新日期:1988-10-27 00:00:00
abstract::Truncation of the tumour suppressor adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin signalling pathway. Apc has a role in development: for example, embryos of mice with truncated Apc do not complete gastrulation. To understand this role more fully, we examined the effect of truncated Apc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02028
更新日期:2003-10-09 00:00:00
abstract::Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24050
更新日期:2017-10-19 00:00:00
abstract::Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03894
更新日期:2005-08-18 00:00:00
abstract::The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307176a0
更新日期:1984-01-12 00:00:00
abstract::The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358347a0
更新日期:1992-07-23 00:00:00
abstract::T lymphocytes are predisposed to recognition of foreign protein fragments bound to cell-surface molecules encoded by the major histocompatibility complex (MHC). There is now compelling evidence that this specificity is a consequence of a selection process operating on developing T lymphocytes in the thymus. As a resul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/341746a0
更新日期:1989-10-26 00:00:00
abstract::An experiment by the Gates Foundation is food for thought for other research agencies. ...
journal_title:Nature
pub_type: 社论
doi:10.1038/4551150a
更新日期:2008-10-30 00:00:00
abstract::The Southern Ocean houses a diverse and productive community of organisms. Unicellular eukaryotic diatoms are the main primary producers in this environment, where photosynthesis is limited by low concentrations of dissolved iron and large seasonal fluctuations in light, temperature and the extent of sea ice. How diat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20803
更新日期:2017-01-26 00:00:00
abstract::Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signallin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11208
更新日期:2012-06-13 00:00:00
abstract::RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16482
更新日期:2016-01-28 00:00:00
abstract::Cellulose is the major polysaccharide component of plant cell walls and is the most abundant organic compound on the planet. A number of bacterial and fungal organisms can use cellulose as a food source, possessing cellulases (cellobiohydrolases and endoglucanases) that can catalyse the hydrolysis of the beta-(1,4) gl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365362a0
更新日期:1993-09-23 00:00:00