Abstract：
:Cellulose is the major polysaccharide component of plant cell walls and is the most abundant organic compound on the planet. A number of bacterial and fungal organisms can use cellulose as a food source, possessing cellulases (cellobiohydrolases and endoglucanases) that can catalyse the hydrolysis of the beta-(1,4) glycosidic bonds. They can be classified into seven distinct families. The three-dimensional structures of members of two of these families are known. Here we report the structure of a third cellulase, endoglucanase V, whose sequence is not represented in any of the above families. The enzyme is structurally distinct from the previously determined cellulases but is similar to a recently characterized plant defence protein. The active site region resembles that of lysozyme, despite the lack of structural similarity between these two enzymes.
journal_name
Naturejournal_title
Natureauthors
Davies GJ,Dodson GG,Hubbard RE,Tolley SP,Dauter Z,Wilson KS,Hjort C,Mikkelsen JM,Rasmussen G,Schülein Mdoi
10.1038/365362a0subject
Has Abstractpub_date
1993-09-23 00:00:00pages
362-4issue
6444eissn
0028-0836issn
1476-4687journal_volume
365pub_type
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