当前位置： SCI文献检索 > NATURE期刊下所有文献 > Phagosomes are competent organelles for antigen cross-presentation.

Phagosomes are competent organelles for antigen cross-presentation.

Abstract：

:The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas peptides present in endo/phagocytic compartments are presented on MHC class II molecules. Despite the apparent segregation of the class I and class II pathways, antigens from intracellular pathogens including mycobacteria, Escherichia coli, Salmonella typhimurium, Brucella abortus and Leishmania, have been shown to elicit an MHC class-I-dependent CD8+ T-cell response, a process referred to as cross-presentation. The cellular mechanisms allowing the cross-presentation pathway are poorly understood. Here we show that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum.

journal_name

Nature

journal_title

Nature

authors

Houde M,Bertholet S,Gagnon E,Brunet S,Goyette G,Laplante A,Princiotta MF,Thibault P,Sacks D,Desjardins M

doi

10.1038/nature01912

keywords:

subject

Has Abstract

pub_date

2003-09-25 00:00:00

pages

402-6

issue

6956

eissn

0028-0836

issn

1476-4687

pii

nature01912

journal_volume

425

pub_type

杂志文章

相关文献

NATURE文献大全
  • Isolation of a spermatozoid-releasing and -attracting substance from female gametophytes of Laminaria digitata.

    abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/279430a0

    authors： Müller DG,Gassmann G,Lüning K

    更新日期：1979-05-31 00:00:00

  • Dissecting the catalytic triad of a serine protease.

    abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/332564a0

    authors： Carter P,Wells JA

    更新日期：1988-04-07 00:00:00

  • Deformation cycles of subduction earthquakes in a viscoelastic Earth.

    abstract：:Subduction zones produce the largest earthquakes. Over the past two decades, space geodesy has revolutionized our view of crustal deformation between consecutive earthquakes. The short time span of modern measurements necessitates comparative studies of subduction zones that are at different stages of the deformation ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11032

    authors： Wang K,Hu Y,He J

    更新日期：2012-04-18 00:00:00

  • Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

    abstract：:CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppressi...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35092584

    authors： Krimpenfort P,Quon KC,Mooi WJ,Loonstra A,Berns A

    更新日期：2001-09-06 00:00:00

  • Template-free RNA synthesis by Q beta replicase.

    abstract：:In the absence of extraneously added template, standard preparations of Q beta replicase spontaneously synthesize RNA in vitro, possibly as a result of RNA contamination. Using special enzyme purifications, Sumper and Luce presented evidence that self-replicating RNA not present ab initio can grow out of 'template-fre...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/321089a0

    authors： Biebricher CK,Eigen M,Luce R

    更新日期：1986-05-01 00:00:00

  • Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.

    abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/375503a0

    authors： Lukas J,Parry D,Aagaard L,Mann DJ,Bartkova J,Strauss M,Peters G,Bartek J

    更新日期：1995-06-08 00:00:00

  • Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.

    abstract：:Acyl carrier protein (ACP) transports the growing fatty acid chain between enzymatic domains of fatty acid synthase (FAS) during biosynthesis. Because FAS enzymes operate on ACP-bound acyl groups, ACP must stabilize and transport the growing lipid chain. ACPs have a central role in transporting starting materials and ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12810

    authors： Nguyen C,Haushalter RW,Lee DJ,Markwick PR,Bruegger J,Caldara-Festin G,Finzel K,Jackson DR,Ishikawa F,O'Dowd B,McCammon JA,Opella SJ,Tsai SC,Burkart MD

    更新日期：2014-01-16 00:00:00

  • Induction of cell death by endogenous nerve growth factor through its p75 receptor.

    abstract：:During development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The trkA-specific ligand NGF has also been shown to activa...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/383166a0

    authors： Frade JM,Rodríguez-Tébar A,Barde YA

    更新日期：1996-09-12 00:00:00

  • Enzymatic activity of the conserved core of a group I self-splicing intron.

    abstract：:Splicing of the Tetrahymena ribosomal intron was first studied by Cech et al., who subsequently demonstrated that the intron RNA catalyses its own excision from a primary transcript to yield mature ribosomal RNA. This intron shares several short conserved sequences and a common secondary structure with several other i...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/322083a0

    authors： Szostak JW

    更新日期：1986-07-03 00:00:00

  • Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice.

    abstract：:Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75). Most TNF-mediated biological responses, such as cell death, gene induction, antiviral activity and cytokine production, have been attributed to TNF-R1 (refs 1-5). Gene targeting ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/372560a0

    authors： Erickson SL,de Sauvage FJ,Kikly K,Carver-Moore K,Pitts-Meek S,Gillett N,Sheehan KC,Schreiber RD,Goeddel DV,Moore MW

    更新日期：1994-12-08 00:00:00

  • Corrigendum: Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.

    abstract：:This corrects the article DOI: 10.1038/nature18614. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/nature25991

    authors： Reischauer S,Stone OA,Villasenor A,Chi N,Jin SW,Martin M,Lee MT,Fukuda N,Marass M,Witty A,Fiddes I,Kuo T,Chung WS,Salek S,Lerrigo R,Alsiö J,Luo S,Tworus D,Augustine SM,Mucenieks S,Nystedt B,Giraldez AJ,Schroth

    更新日期：2018-03-21 00:00:00

  • Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines.

    abstract：:Cyclosporin A (CSA) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. Clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of pati...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/289300a0

    authors： Bird AG,McLachlan SM,Britton S

    更新日期：1981-01-22 00:00:00

  • Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle.

    abstract：:Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterizat...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/362471a0

    authors： Thomas HE,Stunnenberg HG,Stewart AF

    更新日期：1993-04-01 00:00:00

  • The landscape of RNA Pol II binding reveals a stepwise transition during ZGA.

    abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2847-y

    authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

    更新日期：2020-11-01 00:00:00

  • A salt-water reservoir as the source of a compositionally stratified plume on Enceladus.

    abstract：:The discovery of a plume of water vapour and ice particles emerging from warm fractures ('tiger stripes') in Saturn's small, icy moon Enceladus raised the question of whether the plume emerges from a subsurface liquid source or from the decomposition of ice. Previous compositional analyses of particles injected by the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature10175

    authors： Postberg F,Schmidt J,Hillier J,Kempf S,Srama R

    更新日期：2011-06-22 00:00:00

  • Novel cell cycle control of RNA synthesis in yeast.

    abstract：:During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/271726a0

    authors： Fraser RS,Nurse P

    更新日期：1978-02-23 00:00:00

  • Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.

    abstract：:Despite the introduction of antiproliferative drug-eluting stents, coronary heart disease remains the leading cause of death in the United States. In-stent restenosis and bypass graft failure are characterized by excessive smooth muscle cell (SMC) proliferation and concomitant myointima formation with luminal oblitera...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13232

    authors： Deuse T,Hua X,Wang D,Maegdefessel L,Heeren J,Scheja L,Bolaños JP,Rakovic A,Spin JM,Stubbendorff M,Ikeno F,Länger F,Zeller T,Schulte-Uentrop L,Stoehr A,Itagaki R,Haddad F,Eschenhagen T,Blankenberg S,Kiefmann R,Reic

    更新日期：2014-05-29 00:00:00

  • CCR3 is a target for age-related macular degeneration diagnosis and therapy.

    abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08151

    authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

    更新日期：2009-07-09 00:00:00

  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

    abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0215-y

    authors： Kang Y,Kuybeda O,de Waal PW,Mukherjee S,Van Eps N,Dutka P,Zhou XE,Bartesaghi A,Erramilli S,Morizumi T,Gu X,Yin Y,Liu P,Jiang Y,Meng X,Zhao G,Melcher K,Ernst OP,Kossiakoff AA,Subramaniam S,Xu HE

    更新日期：2018-06-01 00:00:00

  • Possible regulatory function of acetylcholine receptor in maintenance of retinotectal synapses.

    abstract：:alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/269218a0

    authors： Freeman JA

    更新日期：1977-09-15 00:00:00

  • Author Correction: Global land change from 1982 to 2016.

    abstract：:In this Letter, errors in Supplementary Table 1 have been corrected. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-018-0573-5

    authors： Song XP,Hansen MC,Stehman SV,Potapov PV,Tyukavina A,Vermote EF,Townshend JR

    更新日期：2018-11-01 00:00:00

  • Whales originated from aquatic artiodactyls in the Eocene epoch of India.

    abstract：:Although the first ten million years of whale evolution are documented by a remarkable series of fossil skeletons, the link to the ancestor of cetaceans has been missing. It was known that whales are related to even-toed ungulates (artiodactyls), but until now no artiodactyls were morphologically close to early whales...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature06343

    authors： Thewissen JG,Cooper LN,Clementz MT,Bajpai S,Tiwari BN

    更新日期：2007-12-20 00:00:00

  • Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

    abstract：:In this Letter, the received date should have been 23 March 2017 instead of 13 April 2018. Authors R.M.K. and O.D.K. were incorrectly denoted as 'equally contributing' authors. The labels for 'control' and 'IFNγ' in Extended Data Fig. 4g were reversed. These have been corrected online. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-018-0370-1

    authors： Nusse YM,Savage AK,Marangoni P,Rosendahl-Huber AKM,Landman TA,de Sauvage FJ,Locksley RM,Klein OD

    更新日期：2018-10-01 00:00:00

  • Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.

    abstract：:MicroRNAs (miRNAs) mediate post-transcriptional gene regulation through association with Argonaute proteins (AGOs). Crystal structures of archaeal and bacterial homologues of AGOs have shown that the MID (middle) domain mediates the interaction with the phosphorylated 5' end of the miRNA guide strand and this interact...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature09039

    authors： Frank F,Sonenberg N,Nagar B

    更新日期：2010-06-10 00:00:00

  • NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.

    abstract：:Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature16959

    authors： He Y,Zeng MY,Yang D,Motro B,Núñez G

    更新日期：2016-02-18 00:00:00

  • Added noise restores recognizability of coarse quantized images.

    abstract：:When a portrait is coarsely quantized into blocks, the block structure hides the face, although lower spatial frequencies of the original image sufficient by themselves for recognition are preserved. Recognition can be recovered by blurring the image, or otherwise attenuating the spurious higher spatial frequency comp...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/305226a0

    authors： Morrone MC,Burr DC,Ross J

    更新日期：1983-09-15 00:00:00

  • Thermochemical structures beneath Africa and the Pacific Ocean.

    abstract：:Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morpholog...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature04066

    authors： McNamara AK,Zhong S

    更新日期：2005-10-20 00:00:00

  • Cooperating with the future.

    abstract：:Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental para...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13530

    authors： Hauser OP,Rand DG,Peysakhovich A,Nowak MA

    更新日期：2014-07-10 00:00:00

  • Polyglutamine tracts regulate beclin 1-dependent autophagy.

    abstract：:Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature22078

    authors： Ashkenazi A,Bento CF,Ricketts T,Vicinanza M,Siddiqi F,Pavel M,Squitieri F,Hardenberg MC,Imarisio S,Menzies FM,Rubinsztein DC

    更新日期：2017-05-04 00:00:00

  • Spontaneous pinwheel annihilation during visual development.

    abstract：:Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process has, however, remained e...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/25736

    authors： Wolf F,Geisel T

    更新日期：1998-09-03 00:00:00