A salt-water reservoir as the source of a compositionally stratified plume on Enceladus.

abstract：:Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...

journal_title：Nature

authors： Huff V,Compton DA,Chao LY,Strong LC,Geiser CF,Saunders GF

更新日期：1988-11-24 00:00:00

abstract：:Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous 'damage'-associated molecular patterns (DAMPs...

journal_title：Nature

authors： Zhang Q,Raoof M,Chen Y,Sumi Y,Sursal T,Junger W,Brohi K,Itagaki K,Hauser CJ

更新日期：2010-03-04 00:00:00

abstract：:Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...

journal_title：Nature

authors： Qin J,Wu SP,Creighton CJ,Dai F,Xie X,Cheng CM,Frolov A,Ayala G,Lin X,Feng XH,Ittmann MM,Tsai SJ,Tsai MJ,Tsai SY

更新日期：2013-01-10 00:00:00

abstract：:Parkinson's disease is the second most common neurodegenerative disorder. Growing evidence indicates a causative role of misfolded forms of the protein α-synuclein in the pathogenesis of Parkinson's disease. Intraneuronal aggregates of α-synuclein occur in Lewy bodies and Lewy neurites, the cytopathological hallmarks ...

journal_title：Nature

authors： Bartels T,Choi JG,Selkoe DJ

更新日期：2011-08-14 00:00:00

abstract：:The reliable detection of single quantum particles has revolutionized the field of quantum optics and quantum information processing. For several years, researchers have aspired to extend such detection possibilities to larger-scale, strongly correlated quantum systems in order to record in situ images of a quantum fl...

journal_title：Nature

authors： Sherson JF,Weitenberg C,Endres M,Cheneau M,Bloch I,Kuhr S

更新日期：2010-09-02 00:00:00

abstract：:Scrapie and related animal and human disorders are neurodegenerative diseases characterized by the formation of a modified, partly proteinase-resistant protein (PrP) of the host, which tends to aggregate as amyloid fibrils and accumulate in the brain of infected individuals. There is a general consensus that the patho...

journal_title：Nature

authors： Xi YG,Ingrosso L,Ladogana A,Masullo C,Pocchiari M

更新日期：1992-04-16 00:00:00

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the ...

journal_title：Nature

authors： Holländer GA,Wang B,Nichogiannopoulou A,Platenburg PP,van Ewijk W,Burakoff SJ,Gutierrez-Ramos JC,Terhorst C

更新日期：1995-01-26 00:00:00

abstract：:A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

journal_title：Nature

authors： Ishijima A,Doi T,Sakurada K,Yanagida T

更新日期：1991-07-25 00:00:00

abstract：:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a compl...

journal_title：Nature

authors： Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,N

更新日期：2014-10-02 00:00:00

abstract：:Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...

journal_title：Nature

authors： Jacobson GR,Rosenbusch JP

更新日期：1976-05-06 00:00:00

abstract：:Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...

journal_title：Nature

authors： Samuel RE,Salmon ED,Briehl RW

更新日期：1990-06-28 00:00:00

abstract：:The kinesin superfamily is a class of microtubule-based mechano-enzymes involved in intracellular transport and chromosome movements. Molecules that move towards either the plus end or the minus end of microtubules are represented within the family. The motor domains of these molecules exhibit considerable sequence ho...

journal_title：Nature

authors： Hoenger A,Sablin EP,Vale RD,Fletterick RJ,Milligan RA

更新日期：1995-07-20 00:00:00

abstract：:Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...

journal_title：Nature

authors： Bader E,Migliorini A,Gegg M,Moruzzi N,Gerdes J,Roscioni SS,Bakhti M,Brandl E,Irmler M,Beckers J,Aichler M,Feuchtinger A,Leitzinger C,Zischka H,Wang-Sattler R,Jastroch M,Tschöp M,Machicao F,Staiger H,Häring HU,Chme

更新日期：2016-07-21 00:00:00

abstract：:Jupiter's ring system has previously been described as being composed of a 'bright' narrow ring and an interior, vertically-extended halo. The one image which reveals this morphology most clearly is Voyager 2's parting shot of the Jupiter system, a wide-angle (WA) view of the ring ansa in forward-scattered light (FDS...

journal_title：Nature

authors： Showalter MR,Burns JA,Cuzzi JN,Pollack JB

更新日期：1985-08-08 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of reside...

journal_title：Nature

authors： Vaux D,Tooze J,Fuller S

更新日期：1990-06-07 00:00:00

abstract：:The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of...

journal_title：Nature

authors： Kim AS,Kakalis LT,Abdul-Manan N,Liu GA,Rosen MK

更新日期：2000-03-09 00:00:00

abstract：:Human leukocyte antigens (HLAs) are highly polymorphic proteins that initiate immunity by presenting pathogen-derived peptides to T cells. HLA polymorphisms mostly map to the antigen-binding cleft, thereby diversifying the repertoire of self-derived and pathogen-derived peptide antigens selected by different HLA allot...

journal_title：Nature

authors： Illing PT,Vivian JP,Dudek NL,Kostenko L,Chen Z,Bharadwaj M,Miles JJ,Kjer-Nielsen L,Gras S,Williamson NA,Burrows SR,Purcell AW,Rossjohn J,McCluskey J

更新日期：2012-06-28 00:00:00

abstract：:At the molecular level, muscle contraction is the result of cyclic interaction between myosin crossbridges, which extend from the thick filament, and the thin filament, which consists mainly of actin. The energy for work done by a single crossbridge during a cycle of attachment, generation of force, shortening and det...

journal_title：Nature

authors： Lombardi V,Piazzesi G,Linari M

更新日期：1992-02-13 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:Adult newts regenerate functional limbs after amputation. This process normally depends on the trophic influence of nerves on the regenerating limbs, particularly in the early stages before differentiation of the regeneration blastema, when it stimulates growth by maintaining high rates of macromolecular synthesis. Th...

journal_title：Nature

authors： Rathbone MP,Petri J,Choo AF,Logan DM,Carlone RL,Foret JE

更新日期：1980-01-24 00:00:00

abstract：:Spectacular fossils from the Early Cretaceous Jehol Group of northeastern China have greatly expanded our knowledge of the diversity and palaeobiology of dinosaurs and early birds, and contributed to our understanding of the origin of birds, of flight, and of feathers. Pennaceous (vaned) feathers and integumentary fil...

journal_title：Nature

authors： Zhang F,Kearns SL,Orr PJ,Benton MJ,Zhou Z,Johnson D,Xu X,Wang X

更新日期：2010-02-25 00:00:00

abstract：: ...

journal_title：Nature

authors： Kelly S,Carrington M

更新日期：2018-11-01 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:The verification of nuclear warheads for arms control involves a paradox: international inspectors will have to gain high confidence in the authenticity of submitted items while learning nothing about them. Proposed inspection systems featuring 'information barriers', designed to hide measurements stored in electronic...

journal_title：Nature

authors： Glaser A,Barak B,Goldston RJ

更新日期：2014-06-26 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Schwörer S,Becker F,Feller C,Baig AH,Köber U,Henze H,Kraus JM,Xin B,Lechel A,Lipka DB,Varghese CS,Schmidt M,Rohs R,Aebersold R,Medina KL,Kestler HA,Neri F,von Maltzahn J,Tümpel S,Rudolph KL

更新日期：2019-08-01 00:00:00

abstract：:Nearly all protocols requiring shared quantum information--such as quantum teleportation or key distribution--rely on entanglement between distant parties. However, entanglement is difficult to characterize experimentally. All existing techniques for doing so, including entanglement witnesses or Bell inequalities, dis...

journal_title：Nature

authors： Walborn SP,Souto Ribeiro PH,Davidovich L,Mintert F,Buchleitner A

更新日期：2006-04-20 00:00:00

abstract：:Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...

journal_title：Nature

authors： de Vries JE,Mendelsohn J,Bont WS

更新日期：1980-02-07 00:00:00

abstract：:The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3). Loss-of-function mutations in these loci cause an identical phenotype in which pattern elements from the anterior...

journal_title：Nature

authors： Martin JR,Raibaud A,Ollo R

更新日期：1994-02-24 00:00:00