Abstract：
:Adult newts regenerate functional limbs after amputation. This process normally depends on the trophic influence of nerves on the regenerating limbs, particularly in the early stages before differentiation of the regeneration blastema, when it stimulates growth by maintaining high rates of macromolecular synthesis. The sequence of biochemical events involved is unknown, but it has been suggested that intracellular cyclic AMP may be a second messenger within the blastema. Many studies have indicated that the neural agent(s) involved might be protein. The recent finding that blastemata contain high levels of catecholamines, however, has implicated noradrenaline (NA) as the neurotrophic agent, and suggested that it works via stimulation of beta-adrenergic receptors on the blastemal cells, thereby raising the intracellular concentrations of cyclic AMP. To test this hypothesis we studied the ability of NA alone and in combination with alpha-and beta-adrenergic antagonists to increase cyclic AMP levels and to mimic the effects of nerves by maintaining high rates of protein synthesis and high mitotic indices (MI) in denervated blastemata in organ culture. We find that although NA raises cyclic AMP levels through a beta-adrenergic effect, it does not maintain high rates of protein synthesis or high MI in cultured blastemata. It is unlikely therefore, that this hypothesis applies.
journal_name
Naturejournal_title
Natureauthors
Rathbone MP,Petri J,Choo AF,Logan DM,Carlone RL,Foret JEdoi
10.1038/283387a0subject
Has Abstractpub_date
1980-01-24 00:00:00pages
387-8issue
5745eissn
0028-0836issn
1476-4687journal_volume
283pub_type
杂志文章相关文献
NATURE文献大全abstract：:Eukaryotic cells contain genes termed proto-oncogenes (c-onc) which have the potential to transform cells in culture and induce tumours in vivo. Most of these genes have been identified by their occasional incorporation into retroviral genomes which can act as natural transducing vectors for these and perhaps other ce...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/309085a0
更新日期：1984-05-03 00:00:00
abstract：:The most basic objection to human embryonic stem (ES) cell research is rooted in the fact that ES cell derivation deprives embryos of any further potential to develop into a complete human being. ES cell lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances, from cleavage st...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04277
更新日期：2006-01-12 00:00:00
abstract：:Photoinduced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species provides an energetic driving force for an electron-transfer reaction1-4. This mechanism is relevant in many areas of chemistry, including the study of natural and artificial photosynthesis, photovoltaics and pho...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2131-1
更新日期：2020-04-01 00:00:00
abstract：:The reaction mechanism of protein folding by the chaperonin GroEL and its regulator GroES has been defined. GroES and substrate protein counteract each other's effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/366228a0
更新日期：1993-11-18 00:00:00
abstract：:The optics of the eye cause different wavelengths of light to be differentially focused at the retina. This phenomenon is due to longitudinal chromatic aberration, a wavelength-dependent change in refractive power. Retinal image quality may consequently vary for the different classes of cone photoreceptors, cells tune...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/417174a
更新日期：2002-05-09 00:00:00
abstract：:The Hubbard model, formulated by physicist John Hubbard in the 1960s1, is a simple theoretical model of interacting quantum particles in a lattice. The model is thought to capture the essential physics of high-temperature superconductors, magnetic insulators and other complex quantum many-body ground states2,3. Althou...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2085-3
更新日期：2020-03-01 00:00:00
abstract：:The recruitment model for gene activation stipulates that an activator works by bringing the transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that many genes can be activated by this mechanism. These findings have implications for our understanding of the nature of activating reg...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/386569a0
更新日期：1997-04-10 00:00:00
abstract：:Aggregation of amyloid-β peptides into fibrils or other self-assembled states is central to the pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40- and 42-residue amyloid-β peptides (Aβ40 and Aβ42) are polymorphic, with variations in molecular structure that depend on fibril growth conditions. Recent e...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20814
更新日期：2017-01-12 00:00:00
abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20116
更新日期：2016-12-08 00:00:00
abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...
journal_title：Nature
pub_type： 社论
doi：10.1038/374663a0
更新日期：1995-04-20 00:00:00
abstract：:Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05573
更新日期：2007-03-01 00:00:00
abstract：:Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1097-3
更新日期：2019-04-01 00:00:00
abstract：:Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively. In nano...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/382609a0
更新日期：1996-08-15 00:00:00
abstract：:Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/326419a0
更新日期：1987-03-26 00:00:00
abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/317449a0
更新日期：1985-10-03 00:00:00
abstract：:Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14899
更新日期：2015-08-27 00:00:00
abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10732
更新日期：2011-12-25 00:00:00
abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/288088a0
更新日期：1980-11-06 00:00:00
abstract：:Over the past eight hundred thousand years, glacial-interglacial cycles oscillated with a period of one hundred thousand years ('100k world'1). Ice core and ocean sediment data have shown that atmospheric carbon dioxide, Antarctic temperature, deep ocean temperature, and global ice volume correlated strongly with each...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1692-3
更新日期：2019-10-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature
pub_type： 已发布勘误
doi：10.1038/s41586-020-2351-4
更新日期：2020-06-01 00:00:00
abstract：:Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developm...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature19948
更新日期：2016-09-15 00:00:00
abstract：:Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. At...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12663
更新日期：2013-10-17 00:00:00
abstract：:The protein TFIIB is a general transcription initiation factor that interacts with a promoter complex (D.DNA) containing the TATA-binding subunit (TFIID tau, or TBP) of TFIID to facilitate subsequent interaction with RNA polymerase II (ref. 2) through the associated TFIIF (ref. 3). The potential bridging function of T...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/363744a0
更新日期：1993-06-24 00:00:00
abstract：:Using data on the global distribution of mammal, bird and amphibian species, Grenyer et al. conclude that planning based on individual taxa does not provide efficient solutions for the conservation of other taxa. They also report that the performance of existing global conservation strategies-endemic bird areas, biodi...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature06374
更新日期：2007-12-06 00:00:00
abstract：:In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1609-1
更新日期：2019-10-01 00:00:00
abstract：:Farming was first introduced to Europe in the mid-seventh millennium bc, and was associated with migrants from Anatolia who settled in the southeast before spreading throughout Europe. Here, to understand the dynamics of this process, we analysed genome-wide ancient DNA data from 225 individuals who lived in southeast...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature25778
更新日期：2018-03-08 00:00:00
abstract：:Highly efficient neutron detectors are critical in many sectors, including national security1,2, medicine3, crystallography4 and astronomy5. The main neutron detection technologies currently used involve 3He-gas-filled proportional counters6 and light scintillators7 for thermalized neutrons. Semiconductors could provi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1886-8
更新日期：2020-01-01 00:00:00
abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375383a0
更新日期：1995-06-01 00:00:00
abstract：:Neuronal dendrites are electrically excitable: they can generate regenerative events such as dendritic spikes in response to sufficiently strong synaptic input. Although such events have been observed in many neuronal types, it is not well understood how active dendrites contribute to the tuning of neuronal output in ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12600
更新日期：2013-11-07 00:00:00
abstract：:High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population hi...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature19792
更新日期：2016-10-13 00:00:00
