Abstract:
:Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developments in the electron microscopy of frozen hydrated samples (cryo-electron microscopy) are providing unprecedented opportunities for the structural characterization of biological macromolecules. This is resulting in a wave of information about processes in the cell that were impossible to characterize with existing techniques in structural biology.
journal_name
Naturejournal_title
Natureauthors
Fernandez-Leiro R,Scheres SHdoi
10.1038/nature19948subject
Has Abstractpub_date
2016-09-15 00:00:00pages
339-46issue
7620eissn
0028-0836issn
1476-4687pii
nature19948journal_volume
537pub_type
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