Abstract:
:Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes.
journal_name
Naturejournal_title
Natureauthors
Rubin EM,Tall Adoi
10.1038/35025236keywords:
subject
Has Abstractpub_date
2000-09-14 00:00:00pages
265-9issue
6801eissn
0028-0836issn
1476-4687journal_volume
407pub_type
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