Testing the genetics underlying the co-evolution of mate choice and ornament in the wild.

abstract：:Many biomolecules are characterized by surfaces containing extended nonpolar regions, and the aggregation and subsequent removal of such surfaces from water is believed to play a critical role in the biomolecular assembly in cells. A better understanding of the hydrophobic hydration of biomolecules may therefore yield...

journal_title：Nature

authors： Cheng YK,Rossky PJ

更新日期：1998-04-16 00:00:00

abstract：:Wild-type p53 protein has many properties consistent with its being the product of a tumour suppressor gene. Although the normal roles of tumour suppressor genes are still largely unknown, it seems that they could be involved in promoting cell differentiation as well as in mediating growth arrest by growth-inhibitory ...

journal_title：Nature

authors： Yonish-Rouach E,Resnitzky D,Lotem J,Sachs L,Kimchi A,Oren M

更新日期：1991-07-25 00:00:00

abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...

journal_title：Nature

authors： Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai G

更新日期：1983-04-14 00:00:00

abstract：:High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....

journal_title：Nature

authors： Balakirev FF,Betts JB,Migliori A,Ono S,Ando Y,Boebinger GS

更新日期：2003-08-21 00:00:00

abstract：:Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and ...

journal_title：Nature

authors： Lee-Six H,Øbro NF,Shepherd MS,Grossmann S,Dawson K,Belmonte M,Osborne RJ,Huntly BJP,Martincorena I,Anderson E,O'Neill L,Stratton MR,Laurenti E,Green AR,Kent DG,Campbell PJ

更新日期：2018-09-01 00:00:00

abstract：:Group I and II introns are mobile elements that propagate by insertion into different genes. Some introns of both types self-splice in vitro by transesterification reactions catalysed by the intron RNA. These transesterifications are reversible, and it has been suggested that reverse splicing followed by reverse trans...

journal_title：Nature

authors： Mohr G,Lambowitz AM

更新日期：1991-11-14 00:00:00

abstract：:Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...

journal_title：Nature

authors： Dannappel M,Vlantis K,Kumari S,Polykratis A,Kim C,Wachsmuth L,Eftychi C,Lin J,Corona T,Hermance N,Zelic M,Kirsch P,Basic M,Bleich A,Kelliher M,Pasparakis M

更新日期：2014-09-04 00:00:00

abstract：:When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids have both structural and regulatory roles. Here we demonstrat...

journal_title：Nature

authors： Gao Y,Cao E,Julius D,Cheng Y

更新日期：2016-06-16 00:00:00

abstract：:One of the outstanding challenges in the field of porous materials is the design and synthesis of chemical structures with exceptionally high surface areas. Such materials are of critical importance to many applications involving catalysis, separation and gas storage. The claim for the highest surface area of a disord...

journal_title：Nature

authors： Chae HK,Siberio-Pérez DY,Kim J,Go Y,Eddaoudi M,Matzger AJ,O'Keeffe M,Yaghi OM

更新日期：2004-02-05 00:00:00

abstract：:Macroscopic mechanical oscillators have been coaxed into a regime of quantum behaviour by direct refrigeration or a combination of refrigeration and laser-like cooling. This result supports the idea that mechanical oscillators may perform useful functions in the processing of quantum information with superconducting c...

journal_title：Nature

authors： Palomaki TA,Harlow JW,Teufel JD,Simmonds RW,Lehnert KW

更新日期：2013-03-14 00:00:00

abstract：:The 37-amino-acid calcitonin gene-related peptide (CGRP) occurs as a result of alternative processing of mRNA from the calcitonin gene. The potency of CGRP as a vasodilator and the occurrence of the peptide in nerves associated with blood vessels suggest an important role for CGRP in the regulation of blood flow. The ...

journal_title：Nature

authors： Brain SD,Williams TJ

更新日期：1988-09-01 00:00:00

abstract：:Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molec...

journal_title：Nature

authors： Nicolaou KC,Winssinger N,Pastor J,Ninkovic S,Sarabia F,He Y,Vourloumis D,Yang Z,Li T,Giannakakou P,Hamel E

更新日期：1997-05-15 00:00:00

abstract：:The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...

journal_title：Nature

authors： Fujimoto S,Yamagishi H

更新日期：1987-05-21 00:00:00

abstract：:Some surprising facts about the most productive institutions emerge when Japanese life-science research is subject to a novel type of assessment. ...

journal_title：Nature

authors： Yamazaki S

更新日期：1994-11-10 00:00:00

abstract：:The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an i...

journal_title：Nature

authors： Khaminets A,Heinrich T,Mari M,Grumati P,Huebner AK,Akutsu M,Liebmann L,Stolz A,Nietzsche S,Koch N,Mauthe M,Katona I,Qualmann B,Weis J,Reggiori F,Kurth I,Hübner CA,Dikic I

更新日期：2015-06-18 00:00:00

abstract：:Water availability limits plant growth and production in almost all terrestrial ecosystems. However, biomes differ substantially in sensitivity of aboveground net primary production (ANPP) to between-year variation in precipitation. Average rain-use efficiency (RUE; ANPP/precipitation) also varies between biomes, supp...

journal_title：Nature

authors： Huxman TE,Smith MD,Fay PA,Knapp AK,Shaw MR,Loik ME,Smith SD,Tissue DT,Zak JC,Weltzin JF,Pockman WT,Sala OE,Haddad BM,Harte J,Koch GW,Schwinning S,Small EE,Williams DG

更新日期：2004-06-10 00:00:00

abstract：:Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of respon...

journal_title：Nature

authors： Mariathasan S,Turley SJ,Nickles D,Castiglioni A,Yuen K,Wang Y,Kadel EE III,Koeppen H,Astarita JL,Cubas R,Jhunjhunwala S,Banchereau R,Yang Y,Guan Y,Chalouni C,Ziai J,Şenbabaoğlu Y,Santoro S,Sheinson D,Hung J,Giltna

更新日期：2018-02-22 00:00:00

abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...

journal_title：Nature

authors： Huisman J,Pham Thi NN,Karl DM,Sommeijer B

更新日期：2006-01-19 00:00:00

abstract：:Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expres...

journal_title：Nature

authors： Takeda A,Baffi JZ,Kleinman ME,Cho WG,Nozaki M,Yamada K,Kaneko H,Albuquerque RJ,Dridi S,Saito K,Raisler BJ,Budd SJ,Geisen P,Munitz A,Ambati BK,Green MG,Ishibashi T,Wright JD,Humbles AA,Gerard CJ,Ogura Y,Pan Y,S

更新日期：2009-07-09 00:00:00

abstract：:Plant growth and development is regulated by a structurally unrelated collection of small molecules called plant hormones. During the last 15 years the number of known plant hormones has grown from five to at least ten. Furthermore, many of the proteins involved in plant hormone signalling pathways have been identifie...

journal_title：Nature

authors： Santner A,Estelle M

更新日期：2009-06-25 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:Language is a uniquely human ability that evolved at some point in the roughly 6,000,000 years since human and chimpanzee lines diverged. Even in the most linguistically impoverished environments, children naturally develop sophisticated language systems. In contrast, reading is a learnt skill that does not develop wi...

journal_title：Nature

authors： Carreiras M,Seghier ML,Baquero S,Estévez A,Lozano A,Devlin JT,Price CJ

更新日期：2009-10-15 00:00:00

abstract：:Opsin, the ligand-free form of the G-protein-coupled receptor rhodopsin, at low pH adopts a conformationally distinct, active G-protein-binding state known as Ops*. A synthetic peptide derived from the main binding site of the heterotrimeric G protein-the carboxy terminus of the alpha-subunit (GalphaCT)-stabilizes Ops...

journal_title：Nature

authors： Scheerer P,Park JH,Hildebrand PW,Kim YJ,Krauss N,Choe HW,Hofmann KP,Ernst OP

更新日期：2008-09-25 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify,...

journal_title：Nature

authors： Froguel P,Vaxillaire M,Sun F,Velho G,Zouali H,Butel MO,Lesage S,Vionnet N,Clément K,Fougerousse F

更新日期：1992-03-12 00:00:00

abstract：:Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely u...

journal_title：Nature

authors： Fujiki R,Hashiba W,Sekine H,Yokoyama A,Chikanishi T,Ito S,Imai Y,Kim J,He HH,Igarashi K,Kanno J,Ohtake F,Kitagawa H,Roeder RG,Brown M,Kato S

更新日期：2011-11-27 00:00:00

abstract：:The selection and design of modern high-performance structural engineering materials is driven by optimizing combinations of mechanical properties such as strength, ductility, toughness, elasticity and requirements for predictable and graceful (non-catastrophic) failure in service. Highly processable bulk metallic gla...

journal_title：Nature

authors： Hofmann DC,Suh JY,Wiest A,Duan G,Lind ML,Demetriou MD,Johnson WL

更新日期：2008-02-28 00:00:00

abstract：:The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...

journal_title：Nature

authors： Rowley DB,Currie BS

更新日期：2006-02-09 00:00:00

abstract：: ...

journal_title：Nature

authors： Rios Rojas C

更新日期：2018-12-01 00:00:00

abstract：:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly e...

journal_title：Nature

authors： Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P

更新日期：1996-03-14 00:00:00

abstract：:Tissue-specific transcription factors regulate several important aspects of embryonic development. They must function in the context of DNA assembled into the higher-order structure of chromatin. Enzymatic complexes such as the Swi/Snf-like BAF complexes remodel chromatin to allow the transcriptional machinery access ...

journal_title：Nature

authors： Lickert H,Takeuchi JK,Von Both I,Walls JR,McAuliffe F,Adamson SL,Henkelman RM,Wrana JL,Rossant J,Bruneau BG

更新日期：2004-11-04 00:00:00