Abstract:
:Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely unknown. In metazoans, reversible protein modification by O-linked N-acetylglucosamine (GlcNAc) is catalysed by two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). However, the significance of GlcNAcylation in chromatin reorganization remains elusive. Here we report that histone H2B is GlcNAcylated at residue S112 by OGT in vitro and in living cells. Histone GlcNAcylation fluctuated in response to extracellular glucose through the hexosamine biosynthesis pathway (HBP). H2B S112 GlcNAcylation promotes K120 monoubiquitination, in which the GlcNAc moiety can serve as an anchor for a histone H2B ubiquitin ligase. H2B S112 GlcNAc was localized to euchromatic areas on fly polytene chromosomes. In a genome-wide analysis, H2B S112 GlcNAcylation sites were observed widely distributed over chromosomes including transcribed gene loci, with some sites co-localizing with H2B K120 monoubiquitination. These findings suggest that H2B S112 GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination, presumably for transcriptional activation.
journal_name
Naturejournal_title
Natureauthors
Fujiki R,Hashiba W,Sekine H,Yokoyama A,Chikanishi T,Ito S,Imai Y,Kim J,He HH,Igarashi K,Kanno J,Ohtake F,Kitagawa H,Roeder RG,Brown M,Kato Sdoi
10.1038/nature10656subject
Has Abstractpub_date
2011-11-27 00:00:00pages
557-60issue
7378eissn
0028-0836issn
1476-4687pii
nature10656journal_volume
480pub_type
杂志文章相关文献
NATURE文献大全abstract::Cytosine DNA methylation is important in regulating gene expression and in silencing transposons and other repetitive sequences. Recent genomic studies in Arabidopsis thaliana have revealed that many endogenous genes are methylated either within their promoters or within their transcribed regions, and that gene methyl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06745
更新日期:2008-03-13 00:00:00
abstract::Cancer genetics has for many years focused on mutational events that have their primary effect within the cancer cell. Recently that focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35077207
更新日期:2001-05-17 00:00:00
abstract::Long-term reconstitution of the lymphohaematopoietic cells of a mouse after lethal irradiation requires the transplantation of at least (5-10) x 10(3) bone marrow cells. Several cell-separation techniques based on cell-surface characteristics have been used in attempts to identify the pluripotent haematopoietic stem c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347188a0
更新日期:1990-09-13 00:00:00
abstract::Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02945
更新日期:2004-09-30 00:00:00
abstract::Introduced in its contemporary form in 1946 (ref. 1), but with roots that go back to the eighteenth century, the gravity law is the prevailing framework with which to predict population movement, cargo shipping volume and inter-city phone calls, as well as bilateral trade flows between nations. Despite its widespread ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10856
更新日期:2012-02-26 00:00:00
abstract::In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number of recent genome-wide association studies suggest that non-coding variation is a significant risk factor for common disorders, but the mechanisms by which this variation...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08451
更新日期:2009-09-10 00:00:00
abstract::Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0768-9
更新日期:2019-01-01 00:00:00
abstract::Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopam...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347080a0
更新日期:1990-09-06 00:00:00
abstract::The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282623a0
更新日期:1979-12-06 00:00:00
abstract::The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation and the equivalent Y-located locus, MIC2Y, was one of the first genes shown ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317739a0
更新日期:1985-10-24 00:00:00
abstract::Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease. Attachment of metal ions to antibodies by means of bifunctional chelating a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316265a0
更新日期:1985-07-18 00:00:00
abstract::An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigator...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09603
更新日期:2011-01-06 00:00:00
abstract::The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage. Here we differentiate mouse embryonic stem cells carrying a st...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08210
更新日期:2009-08-13 00:00:00
abstract::Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283574a0
更新日期:1980-02-07 00:00:00
abstract::In Fig. 6a of this Article, the two dots corresponding to Cidea and S100b were erroneously moved to the top left of the volcano plot; this figure has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1267-3
更新日期:2019-06-01 00:00:00
abstract::Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344461a0
更新日期:1990-03-29 00:00:00
abstract::A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active compe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344633a0
更新日期:1990-04-12 00:00:00
abstract::The distribution of geochemical species in the Earth's interior is largely controlled by fractional melting and crystallization processes that are intimately linked to the thermal state and evolution of the mantle. The existence of patches of dense partial melt at the base of the Earth's mantle, together with estimate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06355
更新日期:2007-12-06 00:00:00
abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08005
更新日期:2009-05-28 00:00:00
abstract::The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10194
更新日期:2011-06-29 00:00:00
abstract::After host entry through mucosal surfaces, human immunodeficiency virus-1 (HIV-1) disseminates to lymphoid tissues to establish a generalized infection of the immune system. The mechanisms by which this virus spreads among permissive target cells locally during the early stages of transmission and systemically during ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11398
更新日期:2012-10-11 00:00:00
abstract::Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25462
更新日期:2018-02-07 00:00:00
abstract::Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361549a0
更新日期:1993-02-11 00:00:00
abstract::Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the develope...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06797
更新日期:2008-02-21 00:00:00
abstract::Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14481
更新日期:2015-05-28 00:00:00
abstract::The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279492a0
更新日期:1979-06-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2544-x
更新日期:2020-08-01 00:00:00
abstract::Anti-cancer agents that have been made selective for tumour cells by exploiting the known differences in the availability of oxygen between normal and transformed cells are a promising development in cancer chemotherapy. We have recently suggested a new type of bioreductive activity which would depend on a two-electro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334080a0
更新日期:1988-07-07 00:00:00
abstract::Approximately 2% of colorectal cancer is linked to pre-existing inflammation known as colitis-associated cancer, but most develops in patients without underlying inflammatory bowel disease. Colorectal cancer often follows a genetic pathway whereby loss of the adenomatous polyposis coli (APC) tumour suppressor and acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11465
更新日期:2012-11-08 00:00:00
abstract::Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an alpha subunit and one of two beta subunits (beta A or beta B). FSH-releasing protein (FRP), al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330765a0
更新日期:1987-12-24 00:00:00