Modulation of the two promoters of the galactose operon of Escherichia coli.

abstract：:Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In p...

journal_title：Nature

authors： Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

更新日期：2017-09-28 00:00:00

abstract：:In the cores of some clusters of galaxies the hot intracluster plasma is dense enough that it should cool radiatively in the cluster's lifetime, leading to continuous 'cooling flows' of gas sinking towards the cluster centre, yet no such cooling flow has been observed. The low observed star-formation rates and cool ga...

journal_title：Nature

authors： McDonald M,Bayliss M,Benson BA,Foley RJ,Ruel J,Sullivan P,Veilleux S,Aird KA,Ashby ML,Bautz M,Bazin G,Bleem LE,Brodwin M,Carlstrom JE,Chang CL,Cho HM,Clocchiatti A,Crawford TM,Crites AT,de Haan T,Desai S,Dobbs M

更新日期：2012-08-16 00:00:00

abstract：:We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (10(2)-10(120)) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following ...

journal_title：Nature

authors： Hirst SJ,Hayes NA,Burridge J,Pearce FL,Foreman JC

更新日期：1993-12-09 00:00:00

abstract：:An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on organocatalysts or transition metal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among possible pericyclic reactions). Nature ac...

journal_title：Nature

authors： Ohashi M,Jamieson CS,Cai Y,Tan D,Kanayama D,Tang MC,Anthony SM,Chari JV,Barber JS,Picazo E,Kakule TB,Cao S,Garg NK,Zhou J,Houk KN,Tang Y

更新日期：2020-10-01 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind t...

journal_title：Nature

authors： Sassanfar M,Szostak JW

更新日期：1993-08-05 00:00:00

abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

journal_title：Nature

authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

更新日期：1986-12-04 00:00:00

abstract：:The homeobox is a 183-base-pair DNA sequence originally found in Drosophila segmentation and homeotic genes. In Drosophila, homeotic genes are clustered in the Antennapedia and Bithorax complexes, collectively called the homeotic gene complex (HOM-C). In the mouse genome, about 40 homeobox genes (Hox) are clustered in...

journal_title：Nature

authors： Tomotsune D,Shoji H,Wakamatsu Y,Kondoh H,Takahashi N

更新日期：1993-09-02 00:00:00

abstract：:Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...

journal_title：Nature

authors： Dou Z,Ghosh K,Vizioli MG,Zhu J,Sen P,Wangensteen KJ,Simithy J,Lan Y,Lin Y,Zhou Z,Capell BC,Xu C,Xu M,Kieckhaefer JE,Jiang T,Shoshkes-Carmel M,Tanim KMAA,Barber GN,Seykora JT,Millar SE,Kaestner KH,Garcia BA,Ada

更新日期：2017-10-19 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are ancient asexually reproducing organisms that form symbioses with the majority of plant species, improving plant nutrition and promoting plant diversity. Little is known about the evolution or organization of the genomes of any eukaryotic symbiont or ancient asexual organism. Dire...

journal_title：Nature

authors： Hijri M,Sanders IR

更新日期：2005-01-13 00:00:00

abstract：:Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...

journal_title：Nature

authors： Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

更新日期：2011-05-19 00:00:00

abstract：:Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and even mild alterations in synapse structure drive functional changes during experience-dependent plasticity and pathological disorders. Key to this architecture is how the distribution of presynaptic vesicle fusion sites corresp...

journal_title：Nature

authors： Tang AH,Chen H,Li TP,Metzbower SR,MacGillavry HD,Blanpied TA

更新日期：2016-08-11 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...

journal_title：Nature

authors： Gréaux S,Irifune T,Higo Y,Tange Y,Arimoto T,Liu Z,Yamada A

更新日期：2019-01-01 00:00:00

abstract：:DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...

journal_title：Nature

authors： Obmolova G,Ban C,Hsieh P,Yang W

更新日期：2000-10-12 00:00:00

abstract：:Human activities are causing Earth's sixth major extinction event-an accelerating decline of the world's stocks of biological diversity at rates 100 to 1,000 times pre-human levels. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space. However, in today's in...

journal_title：Nature

authors： Lenzen M,Moran D,Kanemoto K,Foran B,Lobefaro L,Geschke A

更新日期：2012-06-06 00:00:00

abstract：:The capacity of the rough endoplasmic reticulum (RER) membrane of eukaryotic cells in translocate nascent presecretory proteins from the cytosol to the intracisternal space is preserved on cell fractionation and can be assayed in vitro. Two attempts to characterize this translocation activity have been reported. Warre...

journal_title：Nature

authors： Jackson RC,Walter P,Blobel G

更新日期：1980-07-10 00:00:00

abstract：:Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...

journal_title：Nature

authors： Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson K

更新日期：2021-01-20 00:00:00

abstract：:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cy...

journal_title：Nature

authors： Kaguni JM,Fuller RS,Kornberg A

更新日期：1982-04-15 00:00:00

abstract：:Susceptibility of rodent cells to infection by ecotropic murine leukaemia viruses (MuLV) is determined by binding of the virus envelope to a membrane receptor that has multiple membrane-spanning domains. Cells infected by ecotropic MuLV synthesize envelope protein, gp70, which binds to this receptor, thereby preventin...

journal_title：Nature

authors： Kim JW,Closs EI,Albritton LM,Cunningham JM

更新日期：1991-08-22 00:00:00

abstract：:The proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of the avian sarcoma virus 17 (ref. 1). c-jun encodes one major component of the AP-1 transcription factor complex and is expressed in many organs during mouse development and in the adult. Because of its rapid induction in cells fo...

journal_title：Nature

authors： Hilberg F,Aguzzi A,Howells N,Wagner EF

更新日期：1993-09-09 00:00:00

abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...

journal_title：Nature

authors： Bell RD,Winkler EA,Singh I,Sagare AP,Deane R,Wu Z,Holtzman DM,Betsholtz C,Armulik A,Sallstrom J,Berk BC,Zlokovic BV

更新日期：2012-05-16 00:00:00

abstract：: ...

journal_title：Nature

authors： Larrimore KE,Rancati G

更新日期：2019-02-01 00:00:00

abstract：:Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced...

journal_title：Nature

authors： Chung WH,Hung SI,Hong HS,Hsih MS,Yang LC,Ho HC,Wu JY,Chen YT

更新日期：2004-04-01 00:00:00

abstract：:Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common...

journal_title：Nature

authors： Sarkar AK,Luijten M,Miyashima S,Lenhard M,Hashimoto T,Nakajima K,Scheres B,Heidstra R,Laux T

更新日期：2007-04-12 00:00:00

abstract：: ...

journal_title：Nature

authors： Lewis-Jones H

更新日期：2018-11-01 00:00:00

abstract：:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...

journal_title：Nature

authors： Pin JP,Bettler B

更新日期：2016-12-01 00:00:00

abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...

journal_title：Nature

authors： Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,Meyerson M,Gabriel SB,Lander ES,Getz G

更新日期：2014-01-23 00:00:00

abstract：:When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and prop...

journal_title：Nature

authors： Ketov SV,Sun YH,Nachum S,Lu Z,Checchi A,Beraldin AR,Bai HY,Wang WH,Louzguine-Luzgin DV,Carpenter MA,Greer AL

更新日期：2015-08-13 00:00:00

abstract：: ...

journal_title：Nature

authors： Rivest S

更新日期：2018-11-01 00:00:00