Abstract:
:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cycle of chromosomal replication and mechanisms of priming and fork movement can now be explored using this system.
journal_name
Naturejournal_title
Natureauthors
Kaguni JM,Fuller RS,Kornberg Adoi
10.1038/296623a0subject
Has Abstractpub_date
1982-04-15 00:00:00pages
623-7issue
5858eissn
0028-0836issn
1476-4687journal_volume
296pub_type
杂志文章相关文献
NATURE文献大全abstract::Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initiated by cytosine deamination by the activation-induced deaminase (AID) and completed by error-prone processing of the resulting uracils by mismatch and base excision rep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06547
更新日期:2008-02-14 00:00:00
abstract::Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326419a0
更新日期:1987-03-26 00:00:00
abstract::The search for the earliest fossil evidence of the human lineage has been concentrated in East Africa. Here we report the discovery of six hominid specimens from Chad, central Africa, 2,500 km from the East African Rift Valley. The fossils include a nearly complete cranium and fragmentary lower jaws. The associated fa...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature00879
更新日期:2002-07-11 00:00:00
abstract::Over the last twenty years, there has been rapid growth of a new approach to understanding the evolution of organismic form. This evolutionary developmental biology, or 'evo-devo', is focused on the developmental genetic machinery that lies behind embryological phenotypes, which were all that could be studied in the p...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/415757a
更新日期:2002-02-14 00:00:00
abstract::The availability of methods for the amplification of nucleic acid sequences allows the genetic analysis in vitro of the structural and functional properties of many nucleic acids. We have now developed an in vitro selection and amplification system, and used it to analyse the self-splicing Tetrahymena ribozyme. A much...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347406a0
更新日期:1990-09-27 00:00:00
abstract::The perception of yellow has played a central role in distinguishing two main theories of colour vision. Hering proposed that yellow results from the activation of a distinct retinal-neural mechanism, whereas according to the Young-Helmholtz-Maxwell view, yellow results from the combined activation of red and green co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386066a0
更新日期:1997-03-06 00:00:00
abstract::The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327242a0
更新日期:1987-05-21 00:00:00
abstract::We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04405
更新日期:2005-11-24 00:00:00
abstract::Molecules capable of mimicking the function of a wide range of mechanical devices have been fabricated, with motors that can induce mechanical movement attracting particular attention. Such molecular motors convert light or chemical energy into directional rotary or linear motion, and are usually prepared and operated...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04127
更新日期:2005-10-27 00:00:00
abstract::In Dictyostelium discoideum, carbohydrate binding proteins (CBPs) or lectins have been implicated in the molecular basis of cellular cohesion. To determine the role of these CBPs, we have attempted to isolate structural gene mutants in which the CBPs have a defective affinity for carbohydrate ligands. We now report th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279215a0
更新日期:1979-05-17 00:00:00
abstract::Ligand-gated ion channels are multi-subunit complexes where each subunit-type is encoded by several related genes. Heterologous expression of any one of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits, either alone or with any beta-type subunit, typically yields functional nAChR channels. A ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/380347a0
更新日期:1996-03-28 00:00:00
abstract::The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20173
更新日期:2017-01-12 00:00:00
abstract::The gut microbiota influences development1-3 and homeostasis4-7 of the mammalian immune system, and is associated with human inflammatory8 and immune diseases9,10 as well as responses to immunotherapy11-14. Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2971-8
更新日期:2020-12-01 00:00:00
abstract::Stimuli-responsive hydrogels that undergo abrupt changes in volume in response to external stimuli such as pH, temperature and solvent composition have potential applications in biomedicine and the creation of 'intelligent' materials systems, for example as media for drug delivery, separation processes and protein imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/21619
更新日期:1999-06-24 00:00:00
abstract::Complex I is the first enzyme of the respiratory chain and has a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determined the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09066
更新日期:2010-05-27 00:00:00
abstract::Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344461a0
更新日期:1990-03-29 00:00:00
abstract::A thermal light-emitting source, such as a black body or the incandescent filament of a light bulb, is often presented as a typical example of an incoherent source and is in marked contrast to a laser. Whereas a laser is highly monochromatic and very directional, a thermal source has a broad spectrum and is usually qu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416061a
更新日期:2002-03-07 00:00:00
abstract::Ubiquitin (Ub) has important roles in a wide range of intracellular signalling pathways. In the conventional view, ubiquitin alters the signalling activity of the target protein through covalent modification, but accumulating evidence points to the emerging role of non-covalent interaction between ubiquitin and the ta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13140
更新日期:2014-05-01 00:00:00
abstract::As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22376
更新日期:2017-06-08 00:00:00
abstract::Data from a rocket experiment show details which were not known from ground-based observations. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/226526a0
更新日期:1970-05-09 00:00:00
abstract::In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent inducti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/45738
更新日期:1999-09-16 00:00:00
abstract::Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12143
更新日期:2013-05-09 00:00:00
abstract::Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329451a0
更新日期:1987-10-01 00:00:00
abstract::A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/336379a0
更新日期:1988-11-24 00:00:00
abstract::Post-translational modification (PTM) of proteins plays an important part in mediating protein interactions and/or the recruitment of specific protein targets. PTM can be mediated by the addition of functional groups (for example, acetylation or phosphorylation), peptides (for example, ubiquitylation or sumoylation), ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06420
更新日期:2008-01-03 00:00:00
abstract::The earliest cell fate decision in the mammalian embryo separates the extra-embryonic trophoblast lineage, which forms the fetal portion of the placenta, from the embryonic cell lineages. The body plan of the embryo proper is established only later at gastrulation, when the pluripotent epiblast gives rise to the germ ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35003601
更新日期:2000-03-02 00:00:00
abstract::The nucleotides immediately surrounding intron/exon junctions of genes transcribed by RNA polymerase B can be derived from 'consensus' sequences for donor and acceptor splice sites by only a few base changes. Studies in vivo have underlined the importance of these junction nucleotides for splicing. In higher eukaryote...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/315430a0
更新日期:1985-05-30 00:00:00
abstract::Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is ver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330132a0
更新日期:1987-11-12 00:00:00
abstract::The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369151a0
更新日期:1994-05-12 00:00:00
abstract::Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23276
更新日期:2017-08-10 00:00:00