Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

Abstract:

:Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In pregnant mice, interleukin-17a (IL-17a) produced by T helper 17 (TH17) cells (CD4+ T helper effector cells involved in multiple inflammatory conditions) induces behavioural and cortical abnormalities in the offspring exposed to MIA. However, it is unclear whether other maternal factors are required to promote MIA-associated phenotypes. Moreover, the underlying mechanisms by which MIA leads to T cell activation with increased IL-17a in the maternal circulation are not well understood. Here we show that MIA phenotypes in offspring require maternal intestinal bacteria that promote TH17 cell differentiation. Pregnant mice that had been colonized with mouse commensal segmented filamentous bacteria or human commensal bacteria that induce intestinal TH17 cells were more likely to produce offspring with MIA-associated abnormalities. We also show that small intestine dendritic cells from pregnant, but not from non-pregnant, females secrete IL-1β, IL-23 and IL-6 and stimulate T cells to produce IL-17a upon exposure to MIA. Overall, our data suggest that defined gut commensal bacteria with a propensity to induce TH17 cells may increase the risk of neurodevelopmental disorders in the offspring of pregnant mothers undergoing immune system activation owing to infections or autoinflammatory syndromes.

journal_name

Nature

journal_title

Nature

authors

Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

doi

10.1038/nature23910

subject

Has Abstract

pub_date

2017-09-28 00:00:00

pages

528-532

issue

7673

eissn

0028-0836

issn

1476-4687

pii

nature23910

journal_volume

549

pub_type

杂志文章

相关文献

NATURE文献大全
  • Detection of human papillomavirus DNA in anogenital neoplasias.

    abstract::The presence of papillomaviruses in epithelial-derived cancers from several animal species has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract. Recently, human papillomavirus (HPV) DNA has ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/300771a0

    authors: Zachow KR,Ostrow RS,Bender M,Watts S,Okagaki T,Pass F,Faras AJ

    更新日期:1982-12-23 00:00:00

  • Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs.

    abstract::Post-transcriptional gene regulation frequently occurs through elements in mRNA 3' untranslated regions (UTRs). Although crucial roles for 3'UTR-mediated gene regulation have been found in Caenorhabditis elegans, most C. elegans genes have lacked annotated 3'UTRs. Here we describe a high-throughput method for reliable...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09616

    authors: Jan CH,Friedman RC,Ruby JG,Bartel DP

    更新日期:2011-01-06 00:00:00

  • An alternative approach to establishing trade-offs among greenhouse gases.

    abstract::The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35070541

    authors: Manne AS,Richels RG

    更新日期:2001-04-05 00:00:00

  • An unusual phase transition to a second liquid vortex phase in the superconductor YBa2Cu3O7.

    abstract::A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35078016

    authors: Bouquet F,Marcenat C,Steep E,Calemczuk R,Kwok WK,Welp U,Crabtree GW,Fisher RA,Phillips NE,Schilling A

    更新日期:2001-05-24 00:00:00

  • Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

    abstract::Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/37995

    authors: Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

    更新日期:1997-09-04 00:00:00

  • Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin.

    abstract::Insulin binding to its receptor leads to negatively cooperative interactions among the receptor sites. Studies with 29 insulin analogues (animal insulins and proinsulin, insulin-like growth factor and chemically modified insulins) which vary 1,000-fold in their affinity for the receptor and in their biological potency...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/273504a0

    authors: De Meyts P,Van Obberghen E,Roth J

    更新日期:1978-06-15 00:00:00

  • Biomechanics: independent evolution of running in vampire bats.

    abstract::Most tetrapods have retained terrestrial locomotion since it evolved in the Palaeozoic era, but bats have become so specialized for flight that they have almost lost the ability to manoeuvre on land at all. Vampire bats, which sneak up on their prey along the ground, are an important exception. Here we show that commo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/434292a

    authors: Riskin DK,Hermanson JW

    更新日期:2005-03-17 00:00:00

  • A two-step mechanism for TRF2-mediated chromosome-end protection.

    abstract::Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 (also known as TERF2) has a crucial role in end protection through the suppression of ATM activation and ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11873

    authors: Okamoto K,Bartocci C,Ouzounov I,Diedrich JK,Yates JR 3rd,Denchi EL

    更新日期:2013-02-28 00:00:00

  • The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.

    abstract::Colorectal cancer results from mutations in components of the Wnt pathway that regulate beta-catenin levels. Dishevelled (Dvl or Dsh) signals downstream of Wnt receptors and stabilizes beta-catenin during cell proliferation and embryonic axis formation. Moreover, Dvl contributes to cytoskeletal reorganization during g...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01056

    authors: Capelluto DG,Kutateladze TG,Habas R,Finkielstein CV,He X,Overduin M

    更新日期:2002-10-17 00:00:00

  • Malaria research in the post-genomic era.

    abstract::For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature07361

    authors: Winzeler EA

    更新日期:2008-10-09 00:00:00

  • Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.

    abstract::The generation of reprogrammed induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders holds the promise of increased understanding of the aetiologies of complex diseases and may also facilitate the development of novel therapeutic interventions. We have generated iPSCs from patients with L...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09005

    authors: Carvajal-Vergara X,Sevilla A,D'Souza SL,Ang YS,Schaniel C,Lee DF,Yang L,Kaplan AD,Adler ED,Rozov R,Ge Y,Cohen N,Edelmann LJ,Chang B,Waghray A,Su J,Pardo S,Lichtenbelt KD,Tartaglia M,Gelb BD,Lemischka IR

    更新日期:2010-06-10 00:00:00

  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.

    abstract::In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129 family of inbred strains, and markedly increases TGCT incidence in 129-Ter/Ter males. In 129-Ter/Ter mice, some of the r...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03595

    authors: Youngren KK,Coveney D,Peng X,Bhattacharya C,Schmidt LS,Nickerson ML,Lamb BT,Deng JM,Behringer RR,Capel B,Rubin EM,Nadeau JH,Matin A

    更新日期:2005-05-19 00:00:00

  • A primitive placoderm sheds light on the origin of the jawed vertebrate face.

    abstract::Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12980

    authors: Dupret V,Sanchez S,Goujet D,Tafforeau P,Ahlberg PE

    更新日期:2014-03-27 00:00:00

  • The joining of V and J gene segments creates antibody diversity.

    abstract::The variable regions of mouse kappa (kappa) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The V kappa gene segments code for residues 1 to 95; the J kappa gene segments code for residues 96 to 108 (refs 1-3). This gene organisation is similar to that encoding the V...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/283497a0

    authors: Weigert M,Perry R,Kelley D,Hunkapiller T,Schilling J,Hood L

    更新日期:1980-01-31 00:00:00

  • Single-atom-resolved fluorescence imaging of an atomic Mott insulator.

    abstract::The reliable detection of single quantum particles has revolutionized the field of quantum optics and quantum information processing. For several years, researchers have aspired to extend such detection possibilities to larger-scale, strongly correlated quantum systems in order to record in situ images of a quantum fl...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09378

    authors: Sherson JF,Weitenberg C,Endres M,Cheneau M,Bloch I,Kuhr S

    更新日期:2010-09-02 00:00:00

  • Long-range transport in excitonic dark states in coupled quantum wells.

    abstract::During the past ten years, coupled quantum wells have emerged as a promising system for experiments on Bose condensation of excitons, with numerous theoretical and experimental studies aimed at the demonstration of this effect. One of the issues driving these studies is the possibility of long-range coherent transport...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature00940

    authors: Snoke D,Denev S,Liu Y,Pfeiffer L,West K

    更新日期:2002-08-15 00:00:00

  • Reconstitution of functional receptor for human interleukin-2 in mouse cells.

    abstract::Interleukin-2 (IL-2) has a key role in the antigen-specific clonal growth of T lymphocytes, by virtue of its interaction with a specific cell-surface receptor (IL-2R). The growth signal seems to be delivered by IL-2 bound to the high-affinity, but not the low-affinity, receptor. Genes encoding IL-2 and its receptor (t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/318467a0

    authors: Hatakeyama M,Minamoto S,Uchiyama T,Hardy RR,Yamada G,Taniguchi T

    更新日期:1985-12-05 00:00:00

  • Publisher Correction: Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding.

    abstract::Change history: In Fig. 1b and c of this Letter, the inset times in the DIC and GFP microscopy images should be in minutes ('min') instead of seconds ('s'). This has not been corrected online. ...

    journal_title:Nature

    pub_type: 已发布勘误

    doi:10.1038/s41586-019-1327-8

    authors: Stewart MP,Helenius J,Toyoda Y,Ramanathan SP,Muller DJ,Hyman AA

    更新日期:2019-07-01 00:00:00

  • High-speed countercurrent chromatography.

    abstract::Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/326419a0

    authors: Ito Y

    更新日期:1987-03-26 00:00:00

  • Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas.

    abstract::The carbothermal reduction of silica into silicon requires the use of temperatures well above the silicon melting point (> or =2,000 degrees C). Solid silicon has recently been generated directly from silica at much lower temperatures (< or =850 degrees C) via electrochemical reduction in molten salts. However, the si...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05570

    authors: Bao Z,Weatherspoon MR,Shian S,Cai Y,Graham PD,Allan SM,Ahmad G,Dickerson MB,Church BC,Kang Z,Abernathy HW 3rd,Summers CJ,Liu M,Sandhage KH

    更新日期:2007-03-08 00:00:00

  • Evidence for kinks in DNA folding in the nucleosome.

    abstract::The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/328554a0

    authors: Hogan ME,Rooney TF,Austin RH

    更新日期:1987-08-06 00:00:00

  • Coherent state transfer between itinerant microwave fields and a mechanical oscillator.

    abstract::Macroscopic mechanical oscillators have been coaxed into a regime of quantum behaviour by direct refrigeration or a combination of refrigeration and laser-like cooling. This result supports the idea that mechanical oscillators may perform useful functions in the processing of quantum information with superconducting c...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11915

    authors: Palomaki TA,Harlow JW,Teufel JD,Simmonds RW,Lehnert KW

    更新日期:2013-03-14 00:00:00

  • Effect of ions on the light-sensitive current in retinal rods.

    abstract::The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic sel...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/292502a0

    authors: Yau KW,McNaughton PA,Hodgkin AL

    更新日期:1981-08-06 00:00:00

  • Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree.

    abstract::Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/336167a0

    authors: Kennedy JL,Giuffra LA,Moises HW,Cavalli-Sforza LL,Pakstis AJ,Kidd JR,Castiglione CM,Sjogren B,Wetterberg L,Kidd KK

    更新日期:1988-11-10 00:00:00

  • Explanation for fracture spacing in layered materials

    abstract::The spacing of opening-mode fractures in layered materials--such as certain sedimentary rocks and laminated engineering materials--is often proportional to the thickness of the fractured layer. Experimental studies of this phenomenon show that the spacing initially decreases as extensional strain increases in the dire...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35001550

    authors: Bai T,Pollard DD,Gao H

    更新日期:2000-02-17 00:00:00

  • Ecological opportunity and sexual selection together predict adaptive radiation.

    abstract::A fundamental challenge to our understanding of biodiversity is to explain why some groups of species undergo adaptive radiations, diversifying extensively into many and varied species, whereas others do not. Both extrinsic environmental factors (for example, resource availability, climate) and intrinsic lineage-speci...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11144

    authors: Wagner CE,Harmon LJ,Seehausen O

    更新日期:2012-07-19 00:00:00

  • Multiplicative computation in a visual neuron sensitive to looming.

    abstract::Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01190

    authors: Gabbiani F,Krapp HG,Koch C,Laurent G

    更新日期:2002-11-21 00:00:00

  • Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion.

    abstract::In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/324476a0

    authors: Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

    更新日期:1986-12-04 00:00:00

  • Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.

    abstract::Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin receptor-like receptor (CLR) class B G-protein-coupled receptor and a type 1 transmembrane domain protein, receptor activity-modifying prote...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0535-y

    authors: Liang YL,Khoshouei M,Deganutti G,Glukhova A,Koole C,Peat TS,Radjainia M,Plitzko JM,Baumeister W,Miller LJ,Hay DL,Christopoulos A,Reynolds CA,Wootten D,Sexton PM

    更新日期:2018-09-01 00:00:00

  • Structural details of an adenine tract that does not cause DNA to bend.

    abstract::Runs of adenines (adenine tracts) have been implicated as the main determinant of sequence-directed DNA bending. The most widely used experimental test for bending relies on the observation that bent DNA migrates more slowly than straight DNA on a polyacrylamide electrophoresis gel. It was shown recently that the poly...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/331455a0

    authors: Burkhoff AM,Tullius TD

    更新日期:1988-02-04 00:00:00