An enzymatic Alder-ene reaction.

abstract：:Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...

journal_title：Nature

authors： Kim D,Lewis DL,Graziadei L,Neer EJ,Bar-Sagi D,Clapham DE

更新日期：1989-02-09 00:00:00

abstract：:Oral administration of antigen is used to induce antigen-specific peripheral immune tolerance. As well as preventing systemic immune responses to ingested proteins, oral tolerance to autoantigens has also been used to suppress autoimmune diseases in animals and humans. Both active suppression and clonal anergy are sug...

journal_title：Nature

authors： Chen Y,Inobe J,Marks R,Gonnella P,Kuchroo VK,Weiner HL

更新日期：1995-07-13 00:00:00

abstract：:Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous 'damage'-associated molecular patterns (DAMPs...

journal_title：Nature

authors： Zhang Q,Raoof M,Chen Y,Sumi Y,Sursal T,Junger W,Brohi K,Itagaki K,Hauser CJ

更新日期：2010-03-04 00:00:00

abstract：:On 12 May 2008, the devastating magnitude 7.9 (Wenchuan) earthquake struck the eastern edge of the Tibetan plateau, collapsing buildings and killing thousands in major cities aligned along the western Sichuan basin in China. After such a large-magnitude earthquake, rearrangement of stresses in the crust commonly leads...

journal_title：Nature

authors： Parsons T,Ji C,Kirby E

更新日期：2008-07-24 00:00:00

abstract：:The fruit, which mediates the maturation and dispersal of seeds, is a complex structure unique to flowering plants. Seed dispersal in plants such as Arabidopsis occurs by a process called fruit dehiscence, or pod shatter. Few studies have focused on identifying genes that regulate this process, in spite of the agronom...

journal_title：Nature

authors： Liljegren SJ,Ditta GS,Eshed Y,Savidge B,Bowman JL,Yanofsky MF

更新日期：2000-04-13 00:00:00

abstract：:A basic requirement for quantum information processing systems is the ability to completely control the state of a single qubit. For qubits based on electron spin, a universal single-qubit gate is realized by a rotation of the spin by any angle about an arbitrary axis. Driven, coherent Rabi oscillations between two sp...

journal_title：Nature

authors： Press D,Ladd TD,Zhang B,Yamamoto Y

更新日期：2008-11-13 00:00:00

abstract：:Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1-4. H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and ce...

journal_title：Nature

authors： Wu F,Chi Y,Jiang Z,Xu Y,Xie L,Huang F,Wan D,Ni J,Yuan F,Wu X,Zhang Y,Wang L,Ye R,Byeon B,Wang W,Zhang S,Sima M,Chen S,Zhu M,Pei J,Johnson DM,Zhu S,Cao X,Pei C,Zai Z,Liu Y,Liu T,Swift GB,Zhang W,Y

更新日期：2020-02-01 00:00:00

abstract：:In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway, on activation of the alternative, PI(3)K-AKT-mTOR, pathway (which is ERK independent) or on modul...

journal_title：Nature

authors： Boussemart L,Malka-Mahieu H,Girault I,Allard D,Hemmingsson O,Tomasic G,Thomas M,Basmadjian C,Ribeiro N,Thuaud F,Mateus C,Routier E,Kamsu-Kom N,Agoussi S,Eggermont AM,Désaubry L,Robert C,Vagner S

更新日期：2014-09-04 00:00:00

abstract：:P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y1-like receptors and P2Y12-like receptors. Their ligands are generally charged molecules w...

journal_title：Nature

authors： Zhang K,Zhang J,Gao ZG,Zhang D,Zhu L,Han GW,Moss SM,Paoletta S,Kiselev E,Lu W,Fenalti G,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Numerous post-translational modifications of histones have been described in organisms ranging from yeast to humans. Growing evidence for dynamic regulation of these modifications, position- and modification-specific protein interactions, and biochemical crosstalk between modifications has strengthened the 'histone co...

journal_title：Nature

authors： McGinty RK,Kim J,Chatterjee C,Roeder RG,Muir TW

更新日期：2008-06-05 00:00:00

abstract：:The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...

journal_title：Nature

authors： Spierer A,Spierer P

更新日期：1984-01-12 00:00:00

abstract：:Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...

journal_title：Nature

authors： Krieg AM,Yi AK,Matson S,Waldschmidt TJ,Bishop GA,Teasdale R,Koretzky GA,Klinman DM

更新日期：1995-04-06 00:00:00

abstract：:Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes....

journal_title：Nature

authors： Tsai WW,Wang Z,Yiu TT,Akdemir KC,Xia W,Winter S,Tsai CY,Shi X,Schwarzer D,Plunkett W,Aronow B,Gozani O,Fischle W,Hung MC,Patel DJ,Barton MC

更新日期：2010-12-16 00:00:00

abstract：: ...

journal_title：Nature

authors： Liao SE

更新日期：2018-11-01 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA1. After binding DNA, cGAS synthesizes the messenger 2'3'-cyclic GMP-AMP (cGAMP)2-4, which triggers cell-autonomous defence and the production of type I interferons and pro-inflammatory cytokines via the activation of STING5. In addit...

journal_title：Nature

authors： Michalski S,de Oliveira Mann CC,Stafford CA,Witte G,Bartho J,Lammens K,Hornung V,Hopfner KP

更新日期：2020-11-01 00:00:00

abstract：:Many fermentative bacteria obtain energy for growth by reactions in which the change in free energy (DeltaG') is less than that needed to synthesize ATP. These bacteria couple substrate metabolism directly to ATP synthesis, however, by classical phosphoryl transfer reactions. An explanation for the energy economy of t...

journal_title：Nature

authors： Jackson BE,McInerney MJ

更新日期：2002-01-24 00:00:00

abstract：:An inductor, one of the most fundamental circuit elements in modern electronic devices, generates a voltage proportional to the time derivative of the input current1. Conventional inductors typically consist of a helical coil and induce a voltage as a counteraction to time-varying magnetic flux penetrating the coil, f...

journal_title：Nature

authors： Yokouchi T,Kagawa F,Hirschberger M,Otani Y,Nagaosa N,Tokura Y

更新日期：2020-10-01 00:00:00

abstract：:The formation of a primordial crust is a critical step in the evolution of terrestrial planets but the timing of this process is poorly understood. The mineral zircon is a powerful tool for constraining crust formation because it can be accurately dated with the uranium-to-lead (U-Pb) isotopic decay system and is resi...

journal_title：Nature

authors： Bouvier LC,Costa MM,Connelly JN,Jensen NK,Wielandt D,Storey M,Nemchin AA,Whitehouse MJ,Snape JF,Bellucci JJ,Moynier F,Agranier A,Gueguen B,Schönbächler M,Bizzarro M

更新日期：2018-06-01 00:00:00

abstract：:The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activities,...

journal_title：Nature

authors： Kim J,Xiao H,Bonanno JB,Kalyanaraman C,Brown S,Tang X,Al-Obaidi NF,Patskovsky Y,Babbitt PC,Jacobson MP,Lee YS,Almo SC

更新日期：2013-06-06 00:00:00

abstract：:Biodegradation of crude oil by bacterial activity--which has occurred in the majority of the Earth's oil reserves--is known to reduce greatly the quality of petroleum in reservoirs. For economically successful prospecting for oil, it is therefore important to understand the processes and conditions in geological forma...

journal_title：Nature

authors： Wilhelms A,Larter SR,Head I,Farrimond P,di-Primio R,Zwach C

更新日期：2001-06-28 00:00:00

abstract：:Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...

journal_title：Nature

authors： Wilson AC,Colombe Y,Brown KR,Knill E,Leibfried D,Wineland DJ

更新日期：2014-08-07 00:00:00

abstract：:The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Here we have determined three different crystal structures of the extracellular ligand-binding region of mGluR1--in a complex with glutamate and in two unliganded forms. ...

journal_title：Nature

authors： Kunishima N,Shimada Y,Tsuji Y,Sato T,Yamamoto M,Kumasaka T,Nakanishi S,Jingami H,Morikawa K

更新日期：2000-10-26 00:00:00

abstract：:Large parts of the Antarctic ice sheet lying on bedrock below sea level may be vulnerable to marine-ice-sheet instability (MISI), a self-sustaining retreat of the grounding line triggered by oceanic or atmospheric changes. There is growing evidence that MISI may be underway throughout the Amundsen Sea embayment (ASE),...

journal_title：Nature

authors： Ritz C,Edwards TL,Durand G,Payne AJ,Peyaud V,Hindmarsh RC

更新日期：2015-12-03 00:00:00

abstract：:Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...

journal_title：Nature

authors： van Leyen K,Duvoisin RM,Engelhardt H,Wiedmann M

更新日期：1998-09-24 00:00:00

abstract：:The reversal or displacement of the retinal image by prism spectacles leads to extreme disruption of visually guided behaviour, but after an extended period of visual transformation normal behaviour is gradually restored. It is unclear whether this adaptation involves a change in visual perception, the learning of new...

journal_title：Nature

authors： Sugita Y

更新日期：1996-04-11 00:00:00

abstract：:Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...

journal_title：Nature

authors： Patzelt C,Tager HS,Carroll RJ,Steiner DF

更新日期：1979-11-15 00:00:00

abstract：:Lignin is a complex polymer of phenylpropanoid subunits. It is an essential component of woody tissue, to which it imparts structural rigidity. Lignin is remarkably resistant to degradation by most microbes; nevertheless, a few species of white-rot fungi are able to catalyse its oxidation to CO2. Its biodegradation is...

journal_title：Nature

authors： Tien M,Tu CP

更新日期：1987-04-02 00:00:00

abstract：:We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits...

journal_title：Nature

authors： Pesaran B,Nelson MJ,Andersen RA

更新日期：2008-05-15 00:00:00

abstract：: ...

journal_title：Nature

authors： Larrimore KE,Rancati G

更新日期：2019-02-01 00:00:00

abstract：:In Extended Data Fig. 5d of this Letter, the blots for anti-pS612 and anti-BAK1 were inadvertently duplicated. This figure has been corrected online. ...

journal_title：Nature

authors： Perraki A,DeFalco TA,Derbyshire P,Avila J,Séré D,Sklenar J,Qi X,Stransfeld L,Schwessinger B,Kadota Y,Macho AP,Jiang S,Couto D,Torii KU,Menke FLH,Zipfel C

更新日期：2018-11-01 00:00:00