Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

abstract：:The dopamine-containing projection from the ventral tegmental area of the midbrain to the nucleus accumbens is critically involved in mediating the reinforcing properties of cocaine. Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamin...

journal_title：Nature

authors： Phillips PE,Stuber GD,Heien ML,Wightman RM,Carelli RM

更新日期：2003-04-10 00:00:00

abstract：:Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs ...

journal_title：Nature

authors： Myung K,Chen C,Kolodner RD

更新日期：2001-06-28 00:00:00

abstract：:RNase P is the only endonuclease responsible for processing the 5' end of transfer RNA by cleaving a precursor and leading to tRNA maturation. It contains an RNA component and a protein component and has been identified in all organisms. It was one of the first catalytic RNAs identified and the first that acts as a mu...

journal_title：Nature

authors： Krasilnikov AS,Yang X,Pan T,Mondragón A

更新日期：2003-02-13 00:00:00

abstract：:Despite active transport into Earth's mantle, water has been present on our planet's surface for most of geological time. Yet water disappeared from the Martian surface soon after its formation. Although some of the water on Mars was lost to space via photolysis following the collapse of the planet's magnetic field, t...

journal_title：Nature

authors： Wade J,Dyck B,Palin RM,Moore JDP,Smye AJ

更新日期：2017-12-20 00:00:00

abstract：:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...

journal_title：Nature

authors： Shyamala G,Dickson C

更新日期：1976-07-08 00:00:00

abstract：:Rab GTPases regulate all stages of membrane trafficking, including vesicle budding, cargo sorting, transport, tethering and fusion. In the inactive (GDP-bound) conformation, accessory factors facilitate the targeting of Rab GTPases to intracellular compartments. After nucleotide exchange to the active (GTP-bound) conf...

journal_title：Nature

authors： Eathiraj S,Pan X,Ritacco C,Lambright DG

更新日期：2005-07-21 00:00:00

abstract：:Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking. One likely target for these effects is the hippocampus, a centr...

journal_title：Nature

authors： Gray R,Rajan AS,Radcliffe KA,Yakehiro M,Dani JA

更新日期：1996-10-24 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:Post-translational modification (PTM) of proteins plays an important part in mediating protein interactions and/or the recruitment of specific protein targets. PTM can be mediated by the addition of functional groups (for example, acetylation or phosphorylation), peptides (for example, ubiquitylation or sumoylation), ...

journal_title：Nature

authors： Ahel I,Ahel D,Matsusaka T,Clark AJ,Pines J,Boulton SJ,West SC

更新日期：2008-01-03 00:00:00

abstract：:Adult stem cells undergo asymmetric cell division to self-renew and give rise to differentiated cells that comprise mature tissue. Sister chromatids may be distinguished and segregated nonrandomly in asymmetrically dividing stem cells, although the underlying mechanism and the purpose it may serve remain elusive. Here...

journal_title：Nature

authors： Yadlapalli S,Yamashita YM

更新日期：2013-06-13 00:00:00

abstract：:The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...

journal_title：Nature

authors： Wang Y,Botvinick EL,Zhao Y,Berns MW,Usami S,Tsien RY,Chien S

更新日期：2005-04-21 00:00:00

abstract：:The Southern Ocean houses a diverse and productive community of organisms. Unicellular eukaryotic diatoms are the main primary producers in this environment, where photosynthesis is limited by low concentrations of dissolved iron and large seasonal fluctuations in light, temperature and the extent of sea ice. How diat...

journal_title：Nature

authors： Mock T,Otillar RP,Strauss J,McMullan M,Paajanen P,Schmutz J,Salamov A,Sanges R,Toseland A,Ward BJ,Allen AE,Dupont CL,Frickenhaus S,Maumus F,Veluchamy A,Wu T,Barry KW,Falciatore A,Ferrante MI,Fortunato AE,Glöckner

更新日期：2017-01-26 00:00:00

abstract：:Genetic testing will become the future standard of medical care. Life insurers will also need access to genetic information if the insurance industry is to survive intact and if cover is to remain affordable. ...

journal_title：Nature

authors： Pokorski RJ

更新日期：1995-07-06 00:00:00

abstract：: ...

journal_title：Nature

authors： Schiermeier Q

更新日期：2019-02-01 00:00:00

abstract：:Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...

journal_title：Nature

authors： Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

更新日期：1986-03-06 00:00:00

abstract：:It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

journal_title：Nature

authors： Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

更新日期：2020-05-01 00:00:00

abstract：:Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developm...

journal_title：Nature

authors： Fernandez-Leiro R,Scheres SH

更新日期：2016-09-15 00:00:00

abstract：:The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exo...

journal_title：Nature

authors： Xiang S,Cooper-Morgan A,Jiao X,Kiledjian M,Manley JL,Tong L

更新日期：2009-04-09 00:00:00

abstract：:A hybrid gene was constructed between the beta-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods. ...

journal_title：Nature

authors： Seeburg PH,Shine J,Martial JA,Ivarie RD,Morris JA,Ullrich A,Baxter JD,Goodman HM

更新日期：1978-12-21 00:00:00

abstract：:In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

journal_title：Nature

authors： Payre F,Vincent A,Carreno S

更新日期：1999-07-15 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:The rheological properties of rock salt are of fundamental importance in predicting the long-term evolution of salt-based radioactive waste repositories and strategic storage caverns, and in modelling the formation of salt diapirs and associated oil traps1,2. The short-term, high-stress rheology of rock salt is well k...

journal_title：Nature

authors： Urai JL,Spiers CJ,Zwart HJ,Lister GS

更新日期：1986-12-11 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：:Nerve growth factor (NGF) activity was not detected by bioassay in irides killed immediately after excision but NGF appeared within 24 h in living irides placed in culture or grafted to a host eye. Furthermore, sensory and, although less effective, sympathetic denervation of irides in situ led within 10 days to the ap...

journal_title：Nature

authors： Ebendal T,Olson L,Seiger A,Hedlund KO

更新日期：1980-07-03 00:00:00

abstract：:During cell division, sister chromosomes segregate from each other on a microtubule-based structure called the mitotic spindle. Proteins bind to the centromere, a region of chromosomal DNA, to form the kinetochore, which mediates chromosome attachment to the mitotic spindle microtubules. In the budding yeast Saccharom...

journal_title：Nature

authors： Hyman AA,Middleton K,Centola M,Mitchison TJ,Carbon J

更新日期：1992-10-08 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:Neurotransmitter release is initiated by influx of Ca2+ through voltage-gated Ca2+ channels, within 200 microseconds of the action potential arriving at the synaptic terminal, as the Ca2+ concentration increases from 100 nM to > 200 microM. Exocytosis requires high Ca2+ concentration, with a threshold of 20-50 microM ...

journal_title：Nature

authors： Sheng ZH,Rettig J,Cook T,Catterall WA

更新日期：1996-02-01 00:00:00

abstract：:FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence. Because of its unusual bipartite nature, FokI has been used to create artificial enzymes with new specificities. We have determined the c...

journal_title：Nature

authors： Wah DA,Hirsch JA,Dorner LF,Schildkraut I,Aggarwal AK

更新日期：1997-07-03 00:00:00

abstract：:The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metaboli...

journal_title：Nature

authors： He S,Kahles F,Rattik S,Nairz M,McAlpine CS,Anzai A,Selgrade D,Fenn AM,Chan CT,Mindur JE,Valet C,Poller WC,Halle L,Rotllan N,Iwamoto Y,Wojtkiewicz GR,Weissleder R,Libby P,Fernández-Hernando C,Drucker DJ,Nahrendorf

更新日期：2019-02-01 00:00:00

abstract：:Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Högnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2015-04-16 00:00:00