Hippocampal synaptic transmission enhanced by low concentrations of nicotine.

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:The ability to grow properly sized and good quality crystals is one of the cornerstones of single-crystal diffraction, is advantageous in many industrial-scale chemical processes1-3, and is important for obtaining institutional approvals of new drugs for which high-quality crystallographic data are required4-7. Typica...

journal_title：Nature

authors： Sun JK,Sobolev YI,Zhang W,Zhuang Q,Grzybowski BA

更新日期：2020-03-01 00:00:00

abstract：:During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte ...

journal_title：Nature

authors： Fischer KD,Zmuldzinas A,Gardner S,Barbacid M,Bernstein A,Guidos C

更新日期：1995-03-30 00:00:00

abstract：:Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomo...

journal_title：Nature

authors： Constantino JN,Kennon-McGill S,Weichselbaum C,Marrus N,Haider A,Glowinski AL,Gillespie S,Klaiman C,Klin A,Jones W

更新日期：2017-07-20 00:00:00

abstract：:Reorganizations of the Atlantic meridional overturning circulation were associated with large and abrupt climatic changes in the North Atlantic region during the last glacial period. Projections with climate models suggest that similar reorganizations may also occur in response to anthropogenic global warming. Here I ...

journal_title：Nature

authors： Schmittner A

更新日期：2005-03-31 00:00:00

abstract：:The oxygen evolution reaction has an important role in many alternative-energy schemes because it supplies the protons and electrons required for converting renewable electricity into chemical fuels1-3. Electrocatalysts accelerate the reaction by facilitating the required electron transfer4, as well as the formation a...

journal_title：Nature

authors： Nong HN,Falling LJ,Bergmann A,Klingenhof M,Tran HP,Spöri C,Mom R,Timoshenko J,Zichittella G,Knop-Gericke A,Piccinin S,Pérez-Ramírez J,Cuenya BR,Schlögl R,Strasser P,Teschner D,Jones TE

更新日期：2020-11-01 00:00:00

abstract：:Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...

journal_title：Nature

authors： Das Thakur M,Salangsang F,Landman AS,Sellers WR,Pryer NK,Levesque MP,Dummer R,McMahon M,Stuart DD

更新日期：2013-02-14 00:00:00

abstract：:Nitrogen is an essential nutrient for all organisms that must have been available since the origin of life. Abiotic processes including hydrothermal reduction, photochemical reactions, or lightning discharge could have converted atmospheric N2 into assimilable NH4(+), HCN, or NOx species, collectively termed fixed nit...

journal_title：Nature

authors： Stüeken EE,Buick R,Guy BM,Koehler MC

更新日期：2015-04-30 00:00:00

abstract：:The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infections and major nosocomial infections. This syringe-shaped 3.5-MDa macromolecular ...

journal_title：Nature

authors： Worrall LJ,Hong C,Vuckovic M,Deng W,Bergeron JRC,Majewski DD,Huang RK,Spreter T,Finlay BB,Yu Z,Strynadka NCJ

更新日期：2016-12-22 00:00:00

abstract：:Long-term potentiation of chemical synapses is closely related to memory and learning. Studies of this process have concentrated on chemically mediated excitatory synapses. By contrast, activity-dependent modification of gap junctions, which also widely exist in higher structures such as hippocampus and neocortex, has...

journal_title：Nature

authors： Yang XD,Korn H,Faber DS

更新日期：1990-12-06 00:00:00

abstract：:RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...

journal_title：Nature

authors： Galburt EA,Grill SW,Wiedmann A,Lubkowska L,Choy J,Nogales E,Kashlev M,Bustamante C

更新日期：2007-04-12 00:00:00

abstract：:Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses betwee...

journal_title：Nature

authors： Saeij JP,Coller S,Boyle JP,Jerome ME,White MW,Boothroyd JC

更新日期：2007-01-18 00:00:00

abstract：:The theoretical maximum tensile strain--that is, elongation--of a single-walled carbon nanotube is almost 20%, but in practice only 6% is achieved. Here we show that, at high temperatures, individual single-walled carbon nanotubes can undergo superplastic deformation, becoming nearly 280% longer and 15 times narrower ...

journal_title：Nature

authors： Huang JY,Chen S,Wang ZQ,Kempa K,Wang YM,Jo SH,Chen G,Dresselhaus MS,Ren ZF

更新日期：2006-01-19 00:00:00

abstract：:A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer c...

journal_title：Nature

authors： Tavazoie SF,Alarcón C,Oskarsson T,Padua D,Wang Q,Bos PD,Gerald WL,Massagué J

更新日期：2008-01-10 00:00:00

abstract：:The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This pr...

journal_title：Nature

authors： Goldberg AL

更新日期：2003-12-18 00:00:00

abstract：:The discovery of a repeating fast radio burst (FRB) source1,2, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many recent discoveries and follow-ups3-5, suggesting that repeaters may be rare in the FRB population. Here we report the...

journal_title：Nature

authors： CHIME\/FRB Collaboration.

更新日期：2019-02-01 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00

abstract：:The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the f...

journal_title：Nature

authors： Hilf RJ,Dutzler R

更新日期：2009-01-01 00:00:00

abstract：:Miocene hominoid material is very scarce and has previously only been reported as cranial fragments in the Old World. Here we describe a new specimen of Ouranopithecus macedoniensis, which consists of the right part of the face of an adult male with a portion of the frontal bone, a portion of the left part of the face...

journal_title：Nature

authors： de Bonis L,Bouvrain G,Geraads D,Koufos G

更新日期：1990-06-21 00:00:00

abstract：:The wavelength of light represents a fundamental technological barrier to the production of increasingly smaller features on integrated circuits. New technologies that allow the replication of patterns on scales less than 100 nm need to be developed if increases in computing power are to continue at the present rate. ...

journal_title：Nature

authors： Schaffer E,Thurn-Albrecht T,Russell TP,Steiner U

更新日期：2000-02-24 00:00:00

abstract：: ...

journal_title：Nature

authors： Davies J,Stoett P

更新日期：2018-12-01 00:00:00

abstract：:Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...

journal_title：Nature

authors：

更新日期：1984-07-26 00:00:00

abstract：:Mov13 mice carry a single Moloney murine leukaemia virus (M-MuLV) proviral copy in the first intron of the alpha 1(I) collagen gene. Virus insertion interferes with the synthesis of stable alpha 1(I) collagen messenger RNA and causes a recessive lethal mutation. The virus insertion has induced changes of the methylati...

journal_title：Nature

authors： Hartung S,Jaenisch R,Breindl M

更新日期：1986-03-27 00:00:00

abstract：:Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...

journal_title：Nature

authors： Chen DF,Schneider GE,Martinou JC,Tonegawa S

更新日期：1997-01-30 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...

journal_title：Nature

authors： Pijnappel WW,Esch D,Baltissen MP,Wu G,Mischerikow N,Bergsma AJ,van der Wal E,Han DW,Bruch Hv,Moritz S,Lijnzaad P,Altelaar AF,Sameith K,Zaehres H,Heck AJ,Holstege FC,Schöler HR,Timmers HT

更新日期：2013-03-28 00:00:00

abstract：:The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...

journal_title：Nature

authors：

更新日期：1992-04-02 00:00:00

abstract：:In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...

journal_title：Nature

authors： Haase SB,Reed SI

更新日期：1999-09-23 00:00:00

abstract：:Oxygen and silicon isotope compositions of cherts and studies of protein evolution have been interpreted to reflect ocean temperatures of 55-85 degrees C during the early Palaeoarchaean era ( approximately 3.5 billion years ago). A recent study combining oxygen and hydrogen isotope compositions of cherts, however, mak...

journal_title：Nature

authors： Blake RE,Chang SJ,Lepland A

更新日期：2010-04-15 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:There is compelling evidence that sleep contributes to the long-term consolidation of new memories. This function of sleep has been linked to slow (<1 Hz) potential oscillations, which predominantly arise from the prefrontal neocortex and characterize slow wave sleep. However, oscillations in brain potentials are comm...

journal_title：Nature

authors： Marshall L,Helgadóttir H,Mölle M,Born J

更新日期：2006-11-30 00:00:00