Abstract:
:The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This process is of particular importance in protecting cells against harsh conditions (for example, heat shock or oxidative stress) and in a variety of diseases (for example, cystic fibrosis and the major neurodegenerative diseases). A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded.
journal_name
Naturejournal_title
Natureauthors
Goldberg ALdoi
10.1038/nature02263keywords:
subject
Has Abstractpub_date
2003-12-18 00:00:00pages
895-9issue
6968eissn
0028-0836issn
1476-4687pii
nature02263journal_volume
426pub_type
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