Abstract:
:Retrospective epidemiological data have indicated that cutaneous malignant melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet radiation, particularly in children, rather than from the cumulative lifetime exposure that is associated with other forms of skin cancer. Here we use a genetically engineered mouse model to show that a single dose of burning ultraviolet radiation to neonates, but not adults, is necessary and sufficient to induce tumours with high penetrance which are reminiscent of human melanoma. Our results provide experimental support for epidemiological evidence that childhood sunburn poses a significant risk of developing this potentially fatal disease.
journal_name
Naturejournal_title
Natureauthors
Noonan FP,Recio JA,Takayama H,Duray P,Anver MR,Rush WL,De Fabo EC,Merlino Gdoi
10.1038/35095108keywords:
subject
Has Abstractpub_date
2001-09-20 00:00:00pages
271-2issue
6853eissn
0028-0836issn
1476-4687pii
35095108journal_volume
413pub_type
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