Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks.

abstract：:Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...

journal_title：Nature

authors： von Koenigswald W,Rensberger JM,Pretzschner HU

更新日期：1987-07-09 00:00:00

abstract：:Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senesc...

journal_title：Nature

authors： Yu GL,Bradley JD,Attardi LD,Blackburn EH

更新日期：1990-03-08 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of ...

journal_title：Nature

authors： Garman SC,Wurzburg BA,Tarchevskaya SS,Kinet JP,Jardetzky TS

更新日期：2000-07-20 00:00:00

abstract：:Many precious, 'iron-loving' metals, such as gold, are surprisingly abundant in the accessible parts of the Earth, given the efficiency with which core formation should have removed them to the planet's deep interior. One explanation of their over-abundance is a 'late veneer'--a flux of meteorites added to the Earth a...

journal_title：Nature

authors： Willbold M,Elliott T,Moorbath S

更新日期：2011-09-07 00:00:00

abstract：:The paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer's disease. PHFs are composed of microtubule-associated protein tau, in a hyperphosphorylated state. Hyperphosphorylation of tau results in its inability to bind to...

journal_title：Nature

authors： Goedert M,Jakes R,Spillantini MG,Hasegawa M,Smith MJ,Crowther RA

更新日期：1996-10-10 00:00:00

abstract：:Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

journal_title：Nature

authors： Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

更新日期：2002-05-30 00:00:00

abstract：:Self-reproduction is central to biological life for long-term sustainability and evolutionary adaptation. Although these traits would also be desirable in many engineered systems, the principles of self-reproduction have not been exploited in machine design. Here we create simple machines that act as autonomous modula...

journal_title：Nature

authors： Zykov V,Mytilinaios E,Adams B,Lipson H

更新日期：2005-05-12 00:00:00

abstract：:The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal abscesses, mucocutaneous candidiasis, and abnormalities of bone and connective tissue. Mutations presumed to underlie HIES have recently been ide...

journal_title：Nature

authors： Milner JD,Brenchley JM,Laurence A,Freeman AF,Hill BJ,Elias KM,Kanno Y,Spalding C,Elloumi HZ,Paulson ML,Davis J,Hsu A,Asher AI,O'Shea J,Holland SM,Paul WE,Douek DC

更新日期：2008-04-10 00:00:00

abstract：:Helium is used as a critical tracer throughout the Earth sciences, where its relatively simple isotopic systematics is used to trace degassing from the mantle, to date groundwater and to time the rise of continents. The hydrothermal system at Yellowstone National Park is famous for its high helium-3/helium-4 isotope r...

journal_title：Nature

authors： Lowenstern JB,Evans WC,Bergfeld D,Hunt AG

更新日期：2014-02-20 00:00:00

abstract：:Naturally occurring peptides with biological actions have in most cases been detected by observing their biological activities in crude extracts and their isolation has been followed using bioassays. As a complement to the classical biological detection systems, we have proposed a chemical detection system based on fr...

journal_title：Nature

authors： Tatemoto K,Mutt V

更新日期：1980-06-05 00:00:00

abstract：:Behavioural studies and field observations demonstrate that echolocating bats simultaneously perceive range, direction and shape of multiple objects in the environment as acoustic images derived from echoes. Cortical echo delay-tuned neurons contribute to the perception of object range, because focal inactivation of t...

journal_title：Nature

authors： Dear SP,Simmons JA,Fritz J

更新日期：1993-08-12 00:00:00

abstract：:Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...

journal_title：Nature

authors： Dodson HC,Walliker JR,Frampton S,Douek EE,Fourcin AJ,Bannister LH

更新日期：1986-03-06 00:00:00

abstract：:The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation and the equivalent Y-located locus, MIC2Y, was one of the first genes shown ...

journal_title：Nature

authors： Buckle V,Mondello C,Darling S,Craig IW,Goodfellow PN

更新日期：1985-10-24 00:00:00

abstract：:Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 t...

journal_title：Nature

authors： Santamaría D,Barrière C,Cerqueira A,Hunt S,Tardy C,Newton K,Cáceres JF,Dubus P,Malumbres M,Barbacid M

更新日期：2007-08-16 00:00:00

abstract：:The carotid body type I cell contains amines and has features, both morphological and cytochemical, which indicate that it may also produce a peptide. Many regulatory peptides are now known to be present in both central and peripheral tissues. In the periphery these neuropeptides occur in both classical endocrine (APU...

journal_title：Nature

authors： Wharton J,Polak JM,Pearse AG,McGregor GP,Bryant MG,Bloom SR,Emson PC,Bisgard GE,Will JA

更新日期：1980-03-20 00:00:00

abstract：:Susceptibility to some human diseases is linked, albeit weakly, to major transplantation antigens (HLA) encoded by the major histocompatibility gene complex (MHC). Here we have studied MHC/disease association in inbred strains of mice after intracerebral (i.c.) injection of lymphocytic choriomeningitis virus (LCMV). T...

journal_title：Nature

authors： Zinkernagel RM,Pfau CJ,Hengartner H,Althage A

更新日期：1985-08-29 00:00:00

abstract：:Fast radio bursts are mysterious millisecond-duration transients prevalent in the radio sky. Rapid accumulation of data in recent years has facilitated an understanding of the underlying physical mechanisms of these events. Knowledge gained from the neighbouring fields of gamma-ray bursts and radio pulsars has also of...

journal_title：Nature

authors： Zhang B

更新日期：2020-11-01 00:00:00

abstract：:The generation of strong serological responses to protein antigens in experimental animals usually requires the use of potent adjuvants, most of which cannot be used in human or veterinary vaccines because of deleterious side effects. Attempting to circumvent this problem, we have assessed an adjuvant-free antigen-del...

journal_title：Nature

authors： Carayanniotis G,Barber BH

更新日期：1987-05-07 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li...

journal_title：Nature

authors： Guyader M,Emerman M,Sonigo P,Clavel F,Montagnier L,Alizon M

更新日期：1987-04-16 00:00:00

abstract：:As countries in Europe gradually relaxed lockdown restrictions after the first wave, test-trace-isolate strategies became critical to maintain the incidence of coronavirus disease 2019 (COVID-19) at low levels1,2. Reviewing their shortcomings can provide elements to consider in light of the second wave that is current...

journal_title：Nature

authors： Pullano G,Di Domenico L,Sabbatini CE,Valdano E,Turbelin C,Debin M,Guerrisi C,Kengne-Kuetche C,Souty C,Hanslik T,Blanchon T,Boëlle PY,Figoni J,Vaux S,Campèse C,Bernard-Stoecklin S,Colizza V

更新日期：2020-12-21 00:00:00

abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...

journal_title：Nature

authors： Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai G

更新日期：1983-04-14 00:00:00

abstract：:Genomic imprinting is an allele-specific gene expression system that is important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation. Although it is well known that the de novo DNA methyltransferases Dnmt3a and Dnmt3b are responsible for the establishme...

journal_title：Nature

authors： Yamaguchi S,Shen L,Liu Y,Sendler D,Zhang Y

更新日期：2013-12-19 00:00:00

abstract：:Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and beg...

journal_title：Nature

authors： Surana NK,Kasper DL

更新日期：2017-12-14 00:00:00

abstract：:The classical theory of solids, based on the quantum mechanics of single electrons moving in periodic potentials, provides an excellent description of substances ranging from semiconducting silicon to superconducting aluminium. Over the last fifteen years, it has become increasingly clear that there are substances for...

journal_title：Nature

authors： Yeh A,Soh YA,Brooke J,Aeppli G,Rosenbaum TF,Hayden SM

更新日期：2002-10-03 00:00:00

abstract：:The cell adhesion molecules L1, N-CAM and Ng-CAM have been implicated in cell-cell interactions among developing neural cells. L1 and N-CAM are structurally and functionally distinct molecular entities and act synergistically in mediating Ca2+-independent adhesion between re-aggregating early postnatal cerebellar cell...

journal_title：Nature

authors： Keilhauer G,Faissner A,Schachner M

更新日期：1985-08-22 00:00:00

abstract：:The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...

journal_title：Nature

authors： Gong S,Zheng C,Doughty ML,Losos K,Didkovsky N,Schambra UB,Nowak NJ,Joyner A,Leblanc G,Hatten ME,Heintz N

更新日期：2003-10-30 00:00:00

abstract：:Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocy...

journal_title：Nature

authors： Wendling F,Maraskovsky E,Debili N,Florindo C,Teepe M,Titeux M,Methia N,Breton-Gorius J,Cosman D,Vainchenker W

更新日期：1994-06-16 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels involved in diverse physiological processes ranging from nociception to taste. Despite the importance of ASICs in physiology, we know little about the mechanism of channel activation. Here we show that psalmotoxin activates non-sel...

journal_title：Nature

authors： Baconguis I,Gouaux E

更新日期：2012-09-20 00:00:00