Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.

abstract：:Vitreoscilla, a filamentous bacterium in the Beggiatoa family, synthesizes a soluble haem-protein which has two identical subunits of relative molecular mass 15,775 and two b haems per molecule. It is synthesized in relatively large quantities when the organism, a strict aerobe, is grown under hypoxic conditions. It f...

journal_title：Nature

authors： Wakabayashi S,Matsubara H,Webster DA

更新日期：1986-07-31 00:00:00

abstract：:Endophilin I is a presynaptic protein of unknown function that binds to dynamin, a GTPase that is implicated in endocytosis and recycling of synaptic vesicles. Here we show that endophilin I is essential for the formation of synaptic-like microvesicles (SLMVs) from the plasma membrane. Endophilin I exhibits lysophosph...

journal_title：Nature

authors： Schmidt A,Wolde M,Thiele C,Fest W,Kratzin H,Podtelejnikov AV,Witke W,Huttner WB,Söling HD

更新日期：1999-09-09 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:RNA ligases have essential roles in many cellular processes in eukaryotes, archaea and bacteria, including in RNA repair and stress-induced splicing of messenger RNA. In archaea and eukaryotes, RNA ligases also have a role in transfer RNA splicing to generate functional tRNAs required for protein synthesis. We recentl...

journal_title：Nature

authors： Popow J,Jurkin J,Schleiffer A,Martinez J

更新日期：2014-07-03 00:00:00

abstract：:Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of START proteins, but it remains unclear how these receptors bind ABA and, in turn, how hormone binding leads to inhibition of the downstream ...

journal_title：Nature

authors： Melcher K,Ng LM,Zhou XE,Soon FF,Xu Y,Suino-Powell KM,Park SY,Weiner JJ,Fujii H,Chinnusamy V,Kovach A,Li J,Wang Y,Li J,Peterson FC,Jensen DR,Yong EL,Volkman BF,Cutler SR,Zhu JK,Xu HE

更新日期：2009-12-03 00:00:00

abstract：:Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is ...

journal_title：Nature

authors： Inoue K,Hoshijima K,Sakamoto H,Shimura Y

更新日期：1990-03-29 00:00:00

abstract：:Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I foot...

journal_title：Nature

authors： Vierstra J,Lazar J,Sandstrom R,Halow J,Lee K,Bates D,Diegel M,Dunn D,Neri F,Haugen E,Rynes E,Reynolds A,Nelson J,Johnson A,Frerker M,Buckley M,Kaul R,Meuleman W,Stamatoyannopoulos JA

更新日期：2020-07-01 00:00:00

abstract：:The vertical structure of the recent Arctic warming contains information about the processes governing Arctic climate trends. Graversen et al. argue, on the basis of ERA-40 reanalysis data, that a distinct maximum in 1979-2001 warm-season (April-October) Arctic temperature trends appears around 3 km above ground. Here...

journal_title：Nature

authors： Grant AN,Brönnimann S,Haimberger L

更新日期：2008-09-11 00:00:00

abstract：:The neutron superfluid in most neutron stars should be in a highly turbulent state. If so, this turbulence drastically alters its rotational properties. ...

journal_title：Nature

authors： Greenstein G

更新日期：1970-08-22 00:00:00

abstract：:Electrochemical reduction of carbon dioxide (CO2) to carbon monoxide (CO) is the first step in the synthesis of more complex carbon-based fuels and feedstocks using renewable electricity. Unfortunately, the reaction suffers from slow kinetics owing to the low local concentration of CO2 surrounding typical CO2 reductio...

journal_title：Nature

authors： Liu M,Pang Y,Zhang B,De Luna P,Voznyy O,Xu J,Zheng X,Dinh CT,Fan F,Cao C,de Arquer FP,Safaei TS,Mepham A,Klinkova A,Kumacheva E,Filleter T,Sinton D,Kelley SO,Sargent EH

更新日期：2016-09-15 00:00:00

abstract：:In the pseudogap state of the high-transition-temperature (high-T(c)) copper oxide superconductors, angle-resolved photoemission (ARPES) measurements have seen Fermi arcs-that is, open-ended gapless sections in the large Fermi surface-rather than a closed loop expected of an ordinary metal. This is all the more puzzli...

journal_title：Nature

authors： Meng J,Liu G,Zhang W,Zhao L,Liu H,Jia X,Mu D,Liu S,Dong X,Zhang J,Lu W,Wang G,Zhou Y,Zhu Y,Wang X,Xu Z,Chen C,Zhou XJ

更新日期：2009-11-19 00:00:00

abstract：:The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...

journal_title：Nature

authors： Horuk R,Blundell TL,Lazarus NR,Neville RW,Stone D,Wollmer A

更新日期：1980-08-21 00:00:00

abstract：:Distrust in scientific expertise1-14 is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks2-4, as happened for measles in 20195,6. Homemade remedies7,8 and falsehoods are being shared widely on the Internet, as well as dismi...

journal_title：Nature

authors： Johnson NF,Velásquez N,Restrepo NJ,Leahy R,Gabriel N,El Oud S,Zheng M,Manrique P,Wuchty S,Lupu Y

更新日期：2020-06-01 00:00:00

abstract：:Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

journal_title：Nature

authors： Murphy E,Löfdahl S

更新日期：1984-01-19 00:00:00

abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...

journal_title：Nature

authors： Kang Y,Kuybeda O,de Waal PW,Mukherjee S,Van Eps N,Dutka P,Zhou XE,Bartesaghi A,Erramilli S,Morizumi T,Gu X,Yin Y,Liu P,Jiang Y,Meng X,Zhao G,Melcher K,Ernst OP,Kossiakoff AA,Subramaniam S,Xu HE

更新日期：2018-06-01 00:00:00

abstract：:The McDonough strain of the feline sarcoma virus contains a transforming gene (v-fms) which contains partial nucleotide homology with proto-oncogenes encoding tyrosine kinases. One of the v-fms-encoded products, gp140fms, is a cell surface transmembrane glycoprotein that may function as a growth factor receptor. Altho...

journal_title：Nature

authors： Sariban E,Mitchell T,Kufe D

更新日期：1985-07-04 00:00:00

abstract：: ...

journal_title：Nature

authors： Woolston C

更新日期：2019-01-01 00:00:00

abstract：:The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...

journal_title：Nature

authors： Gemmell NJ,Rutherford K,Prost S,Tollis M,Winter D,Macey JR,Adelson DL,Suh A,Bertozzi T,Grau JH,Organ C,Gardner PP,Muffato M,Patricio M,Billis K,Martin FJ,Flicek P,Petersen B,Kang L,Michalak P,Buckley TR,Wilson M

更新日期：2020-08-01 00:00:00

abstract：:The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...

journal_title：Nature

authors： Ayyer K,Yefanov OM,Oberthür D,Roy-Chowdhury S,Galli L,Mariani V,Basu S,Coe J,Conrad CE,Fromme R,Schaffer A,Dörner K,James D,Kupitz C,Metz M,Nelson G,Xavier PL,Beyerlein KR,Schmidt M,Sarrou I,Spence JC,Weierstall

更新日期：2016-02-11 00:00:00

abstract：: ...

journal_title：Nature

authors： Roduner E

更新日期：2019-03-01 00:00:00

abstract：:In the ocean, the chemical forms of nitrogen that are readily available for biological use (known collectively as 'fixed' nitrogen) fuel the global phytoplankton productivity that exports carbon to the deep ocean. Accordingly, variation in the oceanic fixed nitrogen reservoir has been proposed as a cause of glacial-in...

journal_title：Nature

authors： Straub M,Sigman DM,Ren H,Martínez-García A,Meckler AN,Hain MP,Haug GH

更新日期：2013-09-12 00:00:00

abstract：:Quantum information science involves the storage, manipulation and communication of information encoded in quantum systems, where the phenomena of superposition and entanglement can provide enhancements over what is possible classically. Large-scale quantum information processors require stable and addressable quantum...

journal_title：Nature

authors： Moehring DL,Maunz P,Olmschenk S,Younge KC,Matsukevich DN,Duan LM,Monroe C

更新日期：2007-09-06 00:00:00

abstract：:Granular materials and ordinary fluids react differently to shear stresses. Rather than deforming uniformly, materials such as dry sand or cohesionless powders develop shear bands--narrow zones of large relative particle motion, with essentially rigid adjacent regions. Because shear bands mark areas of flow, material ...

journal_title：Nature

authors： Mueth DM,Debregeas GF,Karczmar GS,Eng PJ,Nagel SR,Jaeger HM

更新日期：2000-07-27 00:00:00

abstract：:Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...

journal_title：Nature

authors： Kikeri D,Sun A,Zeidel ML,Hebert SC

更新日期：1989-06-08 00:00:00

abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...

journal_title：Nature

authors： Jackson JA,Fink GR

更新日期：1981-07-23 00:00:00

abstract：:The mutation brachypodism (bp) alters the length and number of bones in the limbs of mice but spares the axial skeleton. It illustrates the importance of specific genes in controlling the morphogenesis of individual skeletal elements in the tetrapod limb. We now report the isolation of three new members of the transfo...

journal_title：Nature

authors： Storm EE,Huynh TV,Copeland NG,Jenkins NA,Kingsley DM,Lee SJ

更新日期：1994-04-14 00:00:00

abstract：:Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of ...

journal_title：Nature

authors： Jahn R,Fasshauer D

更新日期：2012-10-11 00:00:00

abstract：:Q beta replicase, in the absence of added template, will synthesize RNA autocatalytically. A variety of small RNa species, termed '6S RNAs' are generated. As this reaction purportedly occurs in the absence of template, it has been termed 'de novo' RNA synthesis. The question of whether Q beta replicase can polymerize ...

journal_title：Nature

authors： Hill D,Blumenthal T

更新日期：1983-01-27 00:00:00

abstract：:Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...

journal_title：Nature

authors： Koskelainen A,Ala-Laurila P,Fyhrquist N,Donner K

更新日期：2000-01-13 00:00:00

abstract：:The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of...

journal_title：Nature

authors： Morse B,Rotherg PG,South VJ,Spandorfer JM,Astrin SM

更新日期：1988-05-05 00:00:00