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NATURE文献大全abstract::Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Apoptosis comprises an intrinsic cellular defence against tumorigenesis, which, when suppressed, may contribute to the development of malignancies. The bcl-2 oncogene, which is activated in foll...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/374733a0
更新日期:1995-04-20 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07238
更新日期:2008-09-18 00:00:00
abstract::Estimates of the total number of bacterial species indicate that existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space represented by this division of life. Indeed, environmental DNA samples have been shown to encode many previously unknown classes of proteins and RNAs. B...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08586
更新日期:2009-12-03 00:00:00
abstract::Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19328
更新日期:2016-09-01 00:00:00
abstract::Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTO...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08221
更新日期:2009-07-16 00:00:00
abstract::Early co-transcriptional events during eukaryotic ribosome assembly result in the formation of precursors of the small (40S) and large (60S) ribosomal subunits. A multitude of transient assembly factors regulate and chaperone the systematic folding of pre-ribosomal RNA subdomains. However, owing to a lack of structura...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature26156
更新日期:2018-04-05 00:00:00
abstract::Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02977
更新日期:2004-10-28 00:00:00
abstract::Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25379
更新日期:1998-12-17 00:00:00
abstract::Why sex prevails in nature remains one of the great puzzles of evolution. Sexual reproduction has an immediate cost relative to asexual reproduction, as males only express their contribution to population growth through females. With no males to sustain, an asexual mutant can double its relative representation in the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35005078
更新日期:2000-03-16 00:00:00
abstract::Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12912
更新日期:2014-01-23 00:00:00
abstract::Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12265
更新日期:2013-10-03 00:00:00
abstract::The 3-dimethylsulphoniopropionate (DMSP) produced by marine algae is the main biogenic precursor of atmospheric dimethylsulphide (DMS). This biogenic DMS, formed by bacterial and algal degradation of DMSP, contributes about 1.5 x 10(13) g of sulphur to the atmosphere annually, and plays a major part in the global sulp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43160
更新日期:1997-06-26 00:00:00
abstract::Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05394
更新日期:2007-01-11 00:00:00
abstract::At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations. However, some auditory, vestibular and cerebellar synapses maintain constant streng...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24474
更新日期:2017-11-23 00:00:00
abstract::The three-dimensional organization of the genome supports regulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis. Chromosome conformation capture (Hi-C)1,2 analysis has revealed a complex genomic landscape of internal chromosomal structures in vertebrate cells3-7, but the ident...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2744-4
更新日期:2020-10-01 00:00:00
abstract::Plate tectonics successfully describes the surface of Earth as a mosaic of moving lithospheric plates. But it is not clear what happens at the base of the plates, the lithosphere-asthenosphere boundary (LAB). The LAB has been well imaged with converted teleseismic waves, whose 10-40-kilometre wavelength controls the s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14146
更新日期:2015-02-05 00:00:00
abstract::Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/417541a
更新日期:2002-05-30 00:00:00
abstract::Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of respon...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25501
更新日期:2018-02-22 00:00:00
abstract::In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature07122
更新日期:2008-07-10 00:00:00
abstract::The sense of smell is highly evolved in mammals, allowing discrimination between a vast number of odorants, with detection thresholds as low as 10(-17) M (ref. 1). Although several features of mammalian olfactory transduction have been revealed by biochemical and molecular biological studies, the odorant-induced membr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/366283a0
更新日期:1993-11-18 00:00:00
abstract::The spectral purity of an oscillator is central to many applications, such as detecting gravity waves, defining the second, ground-state cooling and quantum manipulation of nanomechanical objects, and quantum computation. Recent proposals suggest that laser oscillators which use very narrow optical transitions in atom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10920
更新日期:2012-04-04 00:00:00
abstract::Enhancers are DNA sequences that stimulate transcription from eukaryotic promoters. This stimulatory effect can be exerted over large distances and from a position either 5' or 3' of a promoter. Enhancers have been found in the genomes of many viruses, and in some cellular genes such as those encoding immunoglobulin h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322383a0
更新日期:1986-07-24 00:00:00
abstract::Brood parasitism, where a brood of the parasitic species is fostered by the parents of another species, is well known among birds. In most cases, such offspring show a complete reliance upon their host parents for food, protection and warmth until their independence. In other vertebrate groups, however, such total dep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323058a0
更新日期:1986-09-04 00:00:00
abstract::The Tharsis region is the largest volcanic complex on Mars and in the Solar System. Young lava flows cover its surface (from the Amazonian period, less than 3 billion years ago) but its growth started during the Noachian era (more than 3.7 billion years ago). Its position has induced a reorientation of the planet with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17171
更新日期:2016-03-17 00:00:00
abstract::Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-018-0171-6
更新日期:2018-06-01 00:00:00
abstract::During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are cr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001615
更新日期:2000-02-17 00:00:00
abstract::Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09089
更新日期:2010-06-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2351-4
更新日期:2020-06-01 00:00:00
abstract::Signals elicited by binding of the T-cell antigen receptor and the CD4/CD8 co-receptor to major histocompatibility complex (MHC) molecules control the generation of CD4+ (helper) or CD8+ (cytotoxic) T cells from thymic precursors that initially express both co-receptor proteins. These precursors have unique, clonally ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35006664
更新日期:2000-03-30 00:00:00
abstract::Bcl-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma. Bcl-2 has the unique oncogenic role of extending cell survival by inhibiting a variety of apoptotic deaths. An emerging family of Bcl-2-related proteins share two highly conserved regions referred to here as Bcl-2 homology 1 and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369321a0
更新日期:1994-05-26 00:00:00