Abstract:
:The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte. This localization requires several trans-acting factors, including Barentsz and the Mago-Y14 heterodimer, which assemble with oskar mRNA into ribonucleoprotein particles (RNPs) and localize with it at the posterior pole. Although Barentsz localization in the germ line depends on Mago-Y14, no direct interaction between these proteins has been detected. Here, we demonstrate that the translation initiation factor eIF4AIII interacts with Barentsz and is a component of the oskar messenger RNP localization complex. Moreover, eIF4AIII interacts with Mago-Y14 and thus provides a molecular link between Barentsz and the heterodimer. The mammalian Mago (also known as Magoh)-Y14 heterodimer is a component of the exon junction complex. The exon junction complex is deposited on spliced mRNAs and functions in nonsense-mediated mRNA decay (NMD), a surveillance mechanism that degrades mRNAs with premature translation-termination codons. We show that both Barentsz and eIF4AIII are essential for NMD in human cells. Thus, we have identified eIF4AIII and Barentsz as components of a conserved protein complex that is essential for mRNA localization in flies and NMD in mammals.
journal_name
Naturejournal_title
Natureauthors
Palacios IM,Gatfield D,St Johnston D,Izaurralde Edoi
10.1038/nature02351keywords:
subject
Has Abstractpub_date
2004-02-19 00:00:00pages
753-7issue
6976eissn
0028-0836issn
1476-4687pii
nature02351journal_volume
427pub_type
杂志文章相关文献
NATURE文献大全abstract::The 20S cyclosome complex (also known as the anaphase-promoting complex) has ubiquitin ligase activity and is required for mitotic cyclin destruction and sister chromatid separation. The formation and activation of the 20S cyclosome complex is regulated by an unknown mechanism. Here we show that Cut4 (ref. 6) is an es...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384276a0
更新日期:1996-11-21 00:00:00
abstract::Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00859
更新日期:2002-08-15 00:00:00
abstract::The known endothelial mitogens stimulate growth of vascular endothelial cells without regard to their tissue of origin. Here we report a growth factor that is expressed largely in one type of tissue and acts selectively on one type of endothelium. This molecule, called endocrine-gland-derived vascular endothelial grow...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35091000
更新日期:2001-08-30 00:00:00
abstract::In Drosophila melanogaster, the rRNA genes (rDNA) are clustered at single sites on two non-homologous chromosomes, the X and Y. Examination of the structure of X and Y rDNAs with restriction endonucleases reveals that the X rDNA contains repeating units not present in the Y. Such observations, as well as genetic evide...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/263027a0
更新日期:1976-09-02 00:00:00
abstract::Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature06175
更新日期:2007-09-27 00:00:00
abstract::Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03890
更新日期:2005-08-04 00:00:00
abstract::The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342149a0
更新日期:1989-11-09 00:00:00
abstract::Fresnel lenses allow almost perfect imaging in widely different circumstances, but their focus is perfect only for a single wavelength. Wang et al. have shown how the effective bandpass may be widened for X-ray microscopy by using a compound diffractive/refractive lens near to an absorption edge. A compound lens has a...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/426245b
更新日期:2003-11-20 00:00:00
abstract::In Drosophila, a large group of structural genes exhibit coordinate regulation, not because they function in a common developmental pathway but because they happen to reside on the X chromosome. These genes are subjected to the regulatory mechanism of dosage compensation which insures that their phenotypic products ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285573a0
更新日期:1980-06-19 00:00:00
abstract::Genetic models predict that genomic rearrangement in hybrids can facilitate reproductive isolation and the formation of new species by preventing gene flow between the parent species and hybrid (sunflowers are an example). The mechanism underlying hybridization-induced chromosome remodelling is as yet unknown, althoug...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29985
更新日期:1998-05-07 00:00:00
abstract::The injection of Rous sarcoma virus (RSV) into the wing web of newly hatched chicks causes a rapidly growing sarcomatous tumour which is palpable within 1 week of inoculation; and cultures of fibroblasts derived from chick embryos (CEF) and infected with RSV become rapidly transformed. Genetic studies have determined ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309552a0
更新日期:1984-06-07 00:00:00
abstract::DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron microscopy, we report...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14685
更新日期:2015-08-13 00:00:00
abstract::The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells. Here we explore the contribution of the mechanical pressure exerted by tumour growth onto non-tumorous adjacent epithelium. In t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14329
更新日期:2015-07-02 00:00:00
abstract::A characteristic feature of induced pinocytosis in Amoeba proteus is the formation of broad channels by invagination of the cell membrane. This process, which requires Ca2+, occurs in response to depolarising cations. High Ca2+ levels reduce pinocytosis induced by cations such as Na+ and Tris+, whereas pinocytosis ind...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282078a0
更新日期:1979-11-01 00:00:00
abstract::To understand the complex physics of a system with strong electron-electron interactions, the ideal is to control and monitor its properties while tuning an external electric field applied to the system (the electric-field effect). Indeed, complete electric-field control of many-body states in strongly correlated elec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16175
更新日期:2016-01-14 00:00:00
abstract::The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can lead to misfolding, aggregation and degradation1. Cells cope with this challenge by coupling synthesis with polypeptide folding and by using molecular chaperone...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0462-y
更新日期:2018-09-01 00:00:00
abstract::The interrelationships between major living vertebrate, and even chordate, groups are now reasonably well resolved thanks to a large amount of generally congruent data derived from molecular sequences, anatomy and physiology. But fossils provide unexpected combinations of characters that help us to understand how the ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature14437
更新日期:2015-04-23 00:00:00
abstract::The Borrmann effect-a dramatic increase in transparency to X-ray beams-is observed when X-rays satisfying Bragg's law diffract through a perfect crystal. The minimization of absorption seen in the Borrmann effect has been explained by noting that the electric field of the X-ray beam approaches zero amplitude at the cr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07099
更新日期:2008-07-10 00:00:00
abstract::In Dictyostelium discoideum, carbohydrate binding proteins (CBPs) or lectins have been implicated in the molecular basis of cellular cohesion. To determine the role of these CBPs, we have attempted to isolate structural gene mutants in which the CBPs have a defective affinity for carbohydrate ligands. We now report th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279215a0
更新日期:1979-05-17 00:00:00
abstract::Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04245
更新日期:2006-01-19 00:00:00
abstract::Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03115-5
更新日期:2021-01-06 00:00:00
abstract::When electrons are subject to a large external magnetic field, the conventional charge quantum Hall effect dictates that an electronic excitation gap is generated in the sample bulk, but metallic conduction is permitted at the boundary. Recent theoretical models suggest that certain bulk insulators with large spin-orb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06843
更新日期:2008-04-24 00:00:00
abstract::The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290503a0
更新日期:1981-04-09 00:00:00
abstract::'Hot Jupiter' extrasolar planets are expected to be tidally locked because they are close (<0.05 astronomical units, where 1 au is the average Sun-Earth distance) to their parent stars, resulting in permanent daysides and nightsides. By observing systems where the planet and star periodically eclipse each other, sever...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05782
更新日期:2007-05-10 00:00:00
abstract::The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01613
更新日期:2003-05-08 00:00:00
abstract::Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2887-3
更新日期:2021-01-01 00:00:00
abstract::The intracellular free Ca2+ ([Ca2+]i) regulates the K+ conductance (GK) of the many types of cell membrane. The Ca2+ influx during an action potential activates this [Ca2+]i-linked GK in most neurones. In caffeine-treated sympathetic ganglion cells, however, Ca2+ released from an intracellular Ca2+ reservoir site anal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283204a0
更新日期:1980-01-10 00:00:00
abstract::Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04614
更新日期:2006-03-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 社论
doi:10.1038/d41586-018-07529-0
更新日期:2018-11-01 00:00:00
abstract::Electrical current can be completely spin polarized in a class of materials known as half-metals, as a result of the coexistence of metallic nature for electrons with one spin orientation and insulating nature for electrons with the other. Such asymmetric electronic states for the different spins have been predicted f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05180
更新日期:2006-11-16 00:00:00