A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.

abstract：:Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...

journal_title：Nature

authors： Sugimoto Y,Pou P,Abe M,Jelinek P,Pérez R,Morita S,Custance O

更新日期：2007-03-01 00:00:00

abstract：:Predation can be intense, creating strong direct and indirect effects throughout food webs. In addition, ecologists increasingly recognize that fluxes of organisms across ecosystem boundaries can have major consequences for community dynamics. Species with complex life histories often shift habitats during their life ...

journal_title：Nature

authors： Knight TM,McCoy MW,Chase JM,McCoy KA,Holt RD

更新日期：2005-10-06 00:00:00

abstract：:The average air temperature at the Earth's surface has increased by 0.06 degrees C per decade during the 20th century, and by 0.19 degrees C per decade from 1979 to 1998. Climate models generally predict amplified warming in polar regions, as observed in Antarctica's peninsula region over the second half of the 20th c...

journal_title：Nature

authors： Doran PT,Priscu JC,Lyons WB,Walsh JE,Fountain AG,McKnight DM,Moorhead DL,Virginia RA,Wall DH,Clow GD,Fritsen CH,McKay CP,Parsons AN

更新日期：2002-01-31 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:The injection of Rous sarcoma virus (RSV) into the wing web of newly hatched chicks causes a rapidly growing sarcomatous tumour which is palpable within 1 week of inoculation; and cultures of fibroblasts derived from chick embryos (CEF) and infected with RSV become rapidly transformed. Genetic studies have determined ...

journal_title：Nature

authors： Dolberg DS,Bissell MJ

更新日期：1984-06-07 00:00:00

abstract：:Extinction from habitat loss is the signature conservation problem of the twenty-first century. Despite its importance, estimating extinction rates is still highly uncertain because no proven direct methods or reliable data exist for verifying extinctions. The most widely used indirect method is to estimate extinction...

journal_title：Nature

authors： He F,Hubbell SP

更新日期：2011-05-19 00:00:00

abstract：:Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...

journal_title：Nature

authors： Todd JA,Bell JI,McDevitt HO

更新日期：1987-10-15 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues...

journal_title：Nature

authors： Clayton LK,Sieh M,Pious DA,Reinherz EL

更新日期：1989-06-15 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00

abstract：:Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population o...

journal_title：Nature

authors： Peng T,Tian Y,Boogerd CJ,Lu MM,Kadzik RS,Stewart KM,Evans SM,Morrisey EE

更新日期：2013-08-29 00:00:00

abstract：:The mariner transposable element is a small member of the short inverted terminal repeat class thought to transpose through a DNA intermediate. Originally described in Drosophila mauritiana, it is now known in several species of the family Drosophilidae, and in a moth Hyalophora cecropia. Here I use primers designed t...

journal_title：Nature

authors： Robertson HM

更新日期：1993-03-18 00:00:00

abstract：:Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

journal_title：Nature

authors： Coleman SW,Patricelli GL,Borgia G

更新日期：2004-04-15 00:00:00

abstract：:Understanding how the brain constructs movements remains a fundamental challenge in neuroscience. The brain may control complex movements through flexible combination of motor primitives, where each primitive is an element of computation in the sensorimotor map that transforms desired limb trajectories into motor comm...

journal_title：Nature

authors： Thoroughman KA,Shadmehr R

更新日期：2000-10-12 00:00:00

abstract：:Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as 'red tides'. The compound, whose mechanism of action involves binding to and opening of sodium channels, is sufficiently toxic to kill fish at concentrations of nanogram...

journal_title：Nature

authors： Nicolaou KC,Yang Z,Shi G,Gunzner JL,Agrios KA,Gärtner P

更新日期：1998-03-19 00:00:00

abstract：:Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...

journal_title：Nature

authors： Ruschak AM,Religa TL,Breuer S,Witt S,Kay LE

更新日期：2010-10-14 00:00:00

abstract：:In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...

journal_title：Nature

authors： Pietrzyński G,Graczyk D,Gallenne A,Gieren W,Thompson IB,Pilecki B,Karczmarek P,Górski M,Suchomska K,Taormina M,Zgirski B,Wielgórski P,Kołaczkowski Z,Konorski P,Villanova S,Nardetto N,Kervella P,Bresolin F,Kudritzki RP

更新日期：2019-03-01 00:00:00

abstract：:One reason for the failure of chemotherapy in the treatment of advanced cancers may be the outgrowth of multidrug-resistant tumour cells. Multidrug resistance has been modelled in numerous mammalian cell lines in which the phenotype is characterized by a pleiotropic cross-resistance to unrelated drugs. In the study re...

journal_title：Nature

authors： Kartner N,Evernden-Porelle D,Bradley G,Ling V

更新日期：1985-08-29 00:00:00

abstract：:The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conser...

journal_title：Nature

authors： Hrvatin S,Sun S,Wilcox OF,Yao H,Lavin-Peter AJ,Cicconet M,Assad EG,Palmer ME,Aronson S,Banks AS,Griffith EC,Greenberg ME

更新日期：2020-07-01 00:00:00

abstract：:Cosmological models in which dark matter consists of cold elementary particles predict that the dark halo population should extend to masses many orders of magnitude below those at which galaxies can form1-3. Here we report a cosmological simulation of the formation of present-day haloes over the full range of observe...

journal_title：Nature

authors： Wang J,Bose S,Frenk CS,Gao L,Jenkins A,Springel V,White SDM

更新日期：2020-09-01 00:00:00

abstract：:A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins. The...

journal_title：Nature

authors： Höpken UE,Lu B,Gerard NP,Gerard C

更新日期：1996-09-05 00:00:00

abstract：:The University of California at Berkeley has announced the postponement of a planned experiment involving the field testing of bacteria genetically engineered to reduce frost damage to crops. The action came after Jeremy Rifkin, who had earlier filed suit against the National Institutes of Health after its Recombinan...

journal_title：Nature

authors： Budiansky S

更新日期：1983-10-13 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...

journal_title：Nature

authors： Emorine L,Kuehl M,Weir L,Leder P,Max EE

更新日期：1983-08-04 00:00:00

abstract：:The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines...

journal_title：Nature

authors： Baker BS

更新日期：1989-08-17 00:00:00

abstract：:The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Transition metal catalysis has emerged as a powerful tool with which to convert these unreactive bonds into carbon-carbon and carb...

journal_title：Nature

authors： McNally A,Haffemayer B,Collins BS,Gaunt MJ

更新日期：2014-06-05 00:00:00

abstract：:Understanding the capacity of natural populations to adapt to their local environment is a central topic in evolutionary biology. Phenotypic differences between populations may have a genetic basis, but showing that they reflect different adaptive optima requires the quantification of both gene flow and selection. Goo...

journal_title：Nature

authors： Postma E,van Noordwijk AJ

更新日期：2005-01-06 00:00:00

abstract：:All synaptically-based neuropsychological theories of learning postulate that there are changes resulting from neural activity which are long-lasting and confined to specific sets of synapses. In the past decade a form of synaptic strengthening known as long-term potentiation (LTP) has been found which results from hi...

journal_title：Nature

authors： Abraham WC,Goddard GV

更新日期：1983-10-20 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer c...

journal_title：Nature

authors： Tavazoie SF,Alarcón C,Oskarsson T,Padua D,Wang Q,Bos PD,Gerald WL,Massagué J

更新日期：2008-01-10 00:00:00