Direct observation of ligand recognition by T cells.

abstract：:During wild-type development, a protein product of the Caenorhabditis elegans heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early larvae, but is absent in late larvae and adult soma. Gain-of-function lin-14 mutations cause the level of lin-14 protein to remain high throughou...

journal_title：Nature

authors： Ruvkun G,Giusto J

更新日期：1989-03-23 00:00:00

abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...

journal_title：Nature

authors：

更新日期：1995-04-20 00:00:00

abstract：:In the coming decades, a crucial challenge for humanity will be meeting future food demands without undermining further the integrity of the Earth's environmental systems. Agricultural systems are already major forces of global environmental degradation, but population growth and increasing consumption of calorie- and...

journal_title：Nature

authors： Mueller ND,Gerber JS,Johnston M,Ray DK,Ramankutty N,Foley JA

更新日期：2012-10-11 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Modern high-power lasers can generate extreme states of matter that are relevant to astrophysics, equation-of-state studies and fusion energy research. Laser-driven implosions of spherical polymer shells have, for example, achieved an increase in density of 1,000 times relative to the solid state. These densities are ...

journal_title：Nature

authors： Kodama R,Norreys PA,Mima K,Dangor AE,Evans RG,Fujita H,Kitagawa Y,Krushelnick K,Miyakoshi T,Miyanaga N,Norimatsu T,Rose SJ,Shozaki T,Shigemori K,Sunahara A,Tampo M,Tanaka KA,Toyama Y,Yamanaka T,Zepf M

更新日期：2001-08-23 00:00:00

abstract：:Magma intrusions and eruptions commonly produce abrupt changes in seismicity far from magma conduits that cannot be associated with the diffusion of pore fluids or heat. Such 'swarm' seismicity also migrates with time, and often exhibits a 'dog-bone'-shaped distribution. The largest earthquakes in swarms produce after...

journal_title：Nature

authors： Toda S,Stein RS,Sagiya T

更新日期：2002-09-05 00:00:00

abstract：:The function of the Xenopus laevis ribosomal spacer has been studied in vivo and by microinjection of in vitro mutants into Xenopus oocytes. It is shown that the spacer directs specific RNA transcripts which most probably terminate upstream of the ribosomal genes and that it is able to modulate transcription of these ...

journal_title：Nature

authors： Moss T

更新日期：1983-03-17 00:00:00

abstract：:Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pa...

journal_title：Nature

authors： Chien KR

更新日期：2008-05-15 00:00:00

abstract：:Lord Rothschild presents his personal views about the terminology used to describe research and development. ...

journal_title：Nature

authors： Rothschild L

更新日期：1972-10-13 00:00:00

abstract：:Techniques to facilitate controlled interactions between single photons and atoms are now being actively explored. These techniques are important for the practical realization of quantum networks, in which multiple memory nodes that utilize atoms for generation, storage and processing of quantum states are connected b...

journal_title：Nature

authors： Eisaman MD,André A,Massou F,Fleischhauer M,Zibrov AS,Lukin MD

更新日期：2005-12-08 00:00:00

abstract：:MicroRNAs (miRNAs) are approximately 22-nucleotide endogenous RNAs that often repress the expression of complementary messenger RNAs. In animals, miRNAs derive from characteristic hairpins in primary transcripts through two sequential RNase III-mediated cleavages; Drosha cleaves near the base of the stem to liberate a...

journal_title：Nature

authors： Ruby JG,Jan CH,Bartel DP

更新日期：2007-07-05 00:00:00

abstract：:In this Letter, 'released' should have been 'regulated' in the sentence starting: 'Deletion of Atg5 in the host similarly regulated circulating arginine and suppressed tumorigenesis...' This has been corrected online. ...

journal_title：Nature

authors： Poillet-Perez L,Xie X,Zhan L,Yang Y,Sharp DW,Hu ZS,Su X,Maganti A,Jiang C,Lu W,Zheng H,Bosenberg MW,Mehnert JM,Guo JY,Lattime E,Rabinowitz JD,White E

更新日期：2019-01-01 00:00:00

abstract：:The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...

journal_title：Nature

authors： Heenen M,Galand P

更新日期：1980-05-22 00:00:00

abstract：:The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition...

journal_title：Nature

authors： Bredemeyer AL,Sharma GG,Huang CY,Helmink BA,Walker LM,Khor KC,Nuskey B,Sullivan KE,Pandita TK,Bassing CH,Sleckman BP

更新日期：2006-07-27 00:00:00

abstract：:In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...

journal_title：Nature

authors： Sorger PK,Murray AW

更新日期：1992-01-23 00:00:00

abstract：:Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...

journal_title：Nature

authors： Nakada D,Saunders TL,Morrison SJ

更新日期：2010-12-02 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:Quantum criticality is associated with a system composed of a nearly infinite number of interacting quantum degrees of freedom at zero temperature, and it implies that the system looks on average the same regardless of the time- and length scale on which it is observed. Electrons on the atomic scale do not exhibit suc...

journal_title：Nature

authors： van der Marel D,Molegraaf HJ,Zaanen J,Nussinov Z,Carbone F,Damascelli A,Eisaki H,Greven M,Kes PH,Li M

更新日期：2003-09-18 00:00:00

abstract：:Totipotent germline blastomeres in Caenorhabditis elegans contain, but do not respond to, factors that promote somatic differentiation in other embryonic cells. Mutations in the maternal gene pie-1 result in the germline blastomeres adopting somatic cell fates. Here we show that pie-1 encodes a nuclear protein, PIE-1,...

journal_title：Nature

authors： Mello CC,Schubert C,Draper B,Zhang W,Lobel R,Priess JR

更新日期：1996-08-22 00:00:00

abstract：:Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new life forms and functions, and the most general route to this goal is th...

journal_title：Nature

authors： Zhang Y,Ptacin JL,Fischer EC,Aerni HR,Caffaro CE,San Jose K,Feldman AW,Turner CR,Romesberg FE

更新日期：2017-11-29 00:00:00

abstract：:Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...

journal_title：Nature

authors： Winklbauer R,Medina A,Swain RK,Steinbeisser H

更新日期：2001-10-25 00:00:00

abstract：:Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R), thus explaining the inhibitory effect of ag...

journal_title：Nature

authors： Fan W,Boston BA,Kesterson RA,Hruby VJ,Cone RD

更新日期：1997-01-09 00:00:00

abstract：:Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...

journal_title：Nature

authors： Ishida S,Iwamoto T,Kabuto C,Kira M

更新日期：2003-02-13 00:00:00

abstract：:Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common...

journal_title：Nature

authors： Sarkar AK,Luijten M,Miyashima S,Lenhard M,Hashimoto T,Nakajima K,Scheres B,Heidstra R,Laux T

更新日期：2007-04-12 00:00:00

abstract：:Secretory-protein translocation into the endoplasmic reticulum (ER) is thought to be catalysed by integral membrane proteins. Genetic selections uncovered three Saccharomyces cerevisiae genes (SEC61, SEC62 and SEC63), mutations in which block import of precursor proteins into the ER lumen in vivo and in vitro. The DNA...

journal_title：Nature

authors： Deshaies RJ,Sanders SL,Feldheim DA,Schekman R

更新日期：1991-02-28 00:00:00

abstract：:Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocy...

journal_title：Nature

authors： Wendling F,Maraskovsky E,Debili N,Florindo C,Teepe M,Titeux M,Methia N,Breton-Gorius J,Cosman D,Vainchenker W

更新日期：1994-06-16 00:00:00

abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...

journal_title：Nature

authors： Neumann CA,Krause DS,Carman CV,Das S,Dubey DP,Abraham JL,Bronson RT,Fujiwara Y,Orkin SH,Van Etten RA

更新日期：2003-07-31 00:00:00

abstract：:Certain bacteria promote the formation of ice in super-cooled water by means of ice nucleators which contain a unique protein associated with the cell membrane. Ice nucleators in general are believed to act by mimicking the structure of an ice crystal surface, thus imposing an ice-like arrangement on the water molecul...

journal_title：Nature

authors： Parody-Morreale A,Murphy KP,Di Cera E,Fall R,DeVries AL,Gill SJ

更新日期：1988-06-23 00:00:00

abstract：:Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...

journal_title：Nature

authors： Wada K,Dechesne CJ,Shimasaki S,King RG,Kusano K,Buonanno A,Hampson DR,Banner C,Wenthold RJ,Nakatani Y

更新日期：1989-12-07 00:00:00

abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...

journal_title：Nature

authors： Dai L,Korolev KS,Gore J

更新日期：2013-04-18 00:00:00