The human IgE network.

abstract：:In vertebrates, unfertilized eggs (or mature oocytes) are arrested at metaphase of meiosis II by a cytoplasmic activity called cytostatic factor (CSF). The classical Mos-MAPK pathway has long been implicated in CSF arrest of vertebrate eggs, but exactly how it exerts CSF activity remains unclear. Recently, Erp1 (also ...

journal_title：Nature

authors： Inoue D,Ohe M,Kanemori Y,Nobui T,Sagata N

更新日期：2007-04-26 00:00:00

abstract：:The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory ...

journal_title：Nature

authors： Czyzewski BK,Wang DN

更新日期：2012-03-11 00:00:00

abstract：:Eukaryotic cells contain genes termed proto-oncogenes (c-onc) which have the potential to transform cells in culture and induce tumours in vivo. Most of these genes have been identified by their occasional incorporation into retroviral genomes which can act as natural transducing vectors for these and perhaps other ce...

journal_title：Nature

authors： Sutrave P,Bonner TI,Rapp UR,Jansen HW,Patschinsky T,Bister K

更新日期：1984-05-03 00:00:00

abstract：:The remarkable antiquity, diversity and ecological significance of arthropods have inspired numerous attempts to resolve their deep phylogenetic history, but the results of two decades of intensive molecular phylogenetics have been mixed. The discovery that terrestrial insects (Hexapoda) are more closely related to aq...

journal_title：Nature

authors： Regier JC,Shultz JW,Zwick A,Hussey A,Ball B,Wetzer R,Martin JW,Cunningham CW

更新日期：2010-02-25 00:00:00

abstract：:Neuronal circuits across several systems display remarkable plasticity to sensory input during postnatal development. Experience-dependent refinements are often restricted to well-defined critical periods in early life, but how these are established remains mostly unknown. A representative example is the loss of respo...

journal_title：Nature

authors： Fagiolini M,Hensch TK

更新日期：2000-03-09 00:00:00

abstract：:The 18-base-pair sequence element AGGTCGACCAGTACTCCG (the Sal box) signals termination of mouse ribosomal gene transcription. This sequence is recognized by a sequence-specific DNA-binding protein, TTF I, which mediates the termination of transcription by RNA polymerase I (pol I). Subsequently, the ends of the primary...

journal_title：Nature

authors： Kuhn A,Bartsch I,Grummt I

更新日期：1990-04-05 00:00:00

abstract：:Photosystem II is the site of photosynthetic water oxidation and contains 20 subunits with a total molecular mass of 350 kDa. The structure of photosystem II has been reported at resolutions from 3.8 to 2.9 Å. These resolutions have provided much information on the arrangement of protein subunits and cofactors but are...

journal_title：Nature

authors： Umena Y,Kawakami K,Shen JR,Kamiya N

更新日期：2011-05-05 00:00:00

abstract：:Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...

journal_title：Nature

authors： Schaal B,Coureaud G,Langlois D,Giniès C,Sémon E,Perrier G

更新日期：2003-07-03 00:00:00

abstract：:Courtship is an innate sexually dimorphic behaviour that can be observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate this behaviour are developmentally programmed. In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours th...

journal_title：Nature

authors： Datta SR,Vasconcelos ML,Ruta V,Luo S,Wong A,Demir E,Flores J,Balonze K,Dickson BJ,Axel R

更新日期：2008-03-27 00:00:00

abstract：:Palaeomagnetic measurements of meteorites suggest that, shortly after the birth of the Solar System, the molten metallic cores of many small planetary bodies convected vigorously and were capable of generating magnetic fields. Convection on these bodies is currently thought to have been thermally driven, implying that...

journal_title：Nature

authors： Bryson JF,Nichols CI,Herrero-Albillos J,Kronast F,Kasama T,Alimadadi H,van der Laan G,Nimmo F,Harrison RJ

更新日期：2015-01-22 00:00:00

abstract：:Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intrace...

journal_title：Nature

authors： Hata Y,Tsumoto T,Sato H,Hagihara K,Tamura H

更新日期：1988-10-27 00:00:00

abstract：:The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...

journal_title：Nature

authors： Takisawa H,Makinose M

更新日期：1981-03-19 00:00:00

abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

journal_title：Nature

authors： O'Halloran T,Beckerle MC,Burridge K

更新日期：1985-10-03 00:00:00

abstract：:Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...

journal_title：Nature

authors： Noebels JL,Marcom PK,Jalilian-Tehrani MH

更新日期：1991-08-01 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:The battle for survival between bacteria and the viruses that infect them (phages) has led to the evolution of many bacterial defence systems and phage-encoded antagonists of these systems. Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated (cas) genes comprise an adaptive imm...

journal_title：Nature

authors： Bondy-Denomy J,Garcia B,Strum S,Du M,Rollins MF,Hidalgo-Reyes Y,Wiedenheft B,Maxwell KL,Davidson AR

更新日期：2015-10-01 00:00:00

abstract：:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...

journal_title：Nature

authors： Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GM

更新日期：2015-11-05 00:00:00

abstract：:More than twelve morphologically and physiologically distinct subtypes of primary somatosensory neuron report salient features of our internal and external environments1-4. It is unclear how specialized gene expression programs emerge during development to endow these subtypes with their unique properties. To assess t...

journal_title：Nature

authors： Sharma N,Flaherty K,Lezgiyeva K,Wagner DE,Klein AM,Ginty DD

更新日期：2020-01-01 00:00:00

abstract：:Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues...

journal_title：Nature

authors： Clayton LK,Sieh M,Pious DA,Reinherz EL

更新日期：1989-06-15 00:00:00

abstract：:Humans and cats can localize a sound source accurately if its spectrum is fairly broad and flat, as is typical of most natural sounds. However, if sounds are filtered to reduce the width of the spectrum, they result in illusions of sources that are very different from the actual locations, particularly in the up/down ...

journal_title：Nature

authors： Xu L,Furukawa S,Middlebrooks JC

更新日期：1999-06-17 00:00:00

abstract：:Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...

journal_title：Nature

authors： Dannappel M,Vlantis K,Kumari S,Polykratis A,Kim C,Wachsmuth L,Eftychi C,Lin J,Corona T,Hermance N,Zelic M,Kirsch P,Basic M,Bleich A,Kelliher M,Pasparakis M

更新日期：2014-09-04 00:00:00

abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...

journal_title：Nature

authors： Kupperman E,An S,Osborne N,Waldron S,Stainier DY

更新日期：2000-07-13 00:00:00

abstract：:Observations from cultured cells, animal models and patients raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer treatment. However, for this drug addiction trait to become of clinical inte...

journal_title：Nature

authors： Kong X,Kuilman T,Shahrabi A,Boshuizen J,Kemper K,Song JY,Niessen HWM,Rozeman EA,Geukes Foppen MH,Blank CU,Peeper DS

更新日期：2017-10-12 00:00:00

abstract：:In myelinated nerves, segregation of voltage-dependent sodium channels to nodes of Ranvier is crucial for saltatory conduction along axons. As sodium channels associate and colocalize with ankyrin at nodes of Ranvier, one possibility is that sodium channels are recruited and immobilized at axonal sites which are speci...

journal_title：Nature

authors： Joe EH,Angelides K

更新日期：1992-03-26 00:00:00

abstract：:China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...

journal_title：Nature

authors： Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

更新日期：2010-09-02 00:00:00

abstract：:Chromosome conformation capture methods have identified subchromosomal structures of higher-order chromatin interactions called topologically associated domains (TADs) that are separated from each other by boundary regions. By subdividing the genome into discrete regulatory units, TADs restrict the contacts that enhan...

journal_title：Nature

authors： Franke M,Ibrahim DM,Andrey G,Schwarzer W,Heinrich V,Schöpflin R,Kraft K,Kempfer R,Jerković I,Chan WL,Spielmann M,Timmermann B,Wittler L,Kurth I,Cambiaso P,Zuffardi O,Houge G,Lambie L,Brancati F,Pombo A,Vingron M,

更新日期：2016-10-13 00:00:00

abstract：:Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...

journal_title：Nature

authors： Shepherd A,Fricker HA,Farrell SL

更新日期：2018-06-01 00:00:00

abstract：:Fresnel lenses allow almost perfect imaging in widely different circumstances, but their focus is perfect only for a single wavelength. Wang et al. have shown how the effective bandpass may be widened for X-ray microscopy by using a compound diffractive/refractive lens near to an absorption edge. A compound lens has a...

journal_title：Nature

authors： Skinner G,Gorenstein P

更新日期：2003-11-20 00:00:00

abstract：:A new system has been developed for measuring the forces produced by a small number (less than 5-150) of myosin molecules interacting with a single actin filament in vitro. The technique can resolve forces of less than a piconewton and has a time resolution in the submillisecond range. It can thus detect fluctuations ...

journal_title：Nature

authors： Ishijima A,Doi T,Sakurada K,Yanagida T

更新日期：1991-07-25 00:00:00

abstract：:Transection of a sensory nerve in adults results in profound abnormalities in sensory perception, even if the severed nerve is surgically repaired to facilitate accurate nerve regeneration. In marked contrast, fewer perceptual errors follow nerve transection and surgical repair in children. The basis for this superior...

journal_title：Nature

authors： Florence SL,Jain N,Pospichal MW,Beck PD,Sly DL,Kaas JH

更新日期：1996-05-02 00:00:00