Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences.

abstract：:Binocular coordination of eye movements is essential for stereopsis (depth perception) and to prevent double vision. More than a century ago, Hering and Helmholtz debated the neural basis of binocular coordination. Helmholtz believed that each eye is controlled independently and that binocular coordination is learned....

journal_title：Nature

authors： Zhou W,King WM

更新日期：1998-06-18 00:00:00

abstract：:The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

journal_title：Nature

authors： Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

更新日期：2008-07-03 00:00:00

abstract：:Activity-dependent change in the efficacy of transmission is a basic feature of many excitatory synapses in the central nervous system. The best understood postsynaptic modification involves a change in responsiveness of AMPAR (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor)-mediated currents follo...

journal_title：Nature

authors： Liu SQ,Cull-Candy SG

更新日期：2000-05-25 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00

abstract：:The upper temperature at which a living system can exist is limited by the hydrolytic breakdown rate of its chemical constituents. The peptide bonds of proteins, the phosphodiester and N-glycosyl bonds in RNA and DNA, and the pyrophosphate and N-glycosyl bonds in nucleotides such as ATP and NAD are among the more impo...

journal_title：Nature

authors： White RH

更新日期：1984-08-02 00:00:00

abstract：:Following the introduction of silicon-based integrated circuitry over three decades ago, the integration density of such circuits has doubled every 12 to 18 months: this observation is known as Moore's law. For this historical trend to continue, significant challenges need to be overcome in several key technological a...

journal_title：Nature

authors： Peercy PS

更新日期：2000-08-31 00:00:00

abstract：:The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...

journal_title：Nature

authors： Song R,Walentek P,Sponer N,Klimke A,Lee JS,Dixon G,Harland R,Wan Y,Lishko P,Lize M,Kessel M,He L

更新日期：2014-06-05 00:00:00

abstract：:Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterizat...

journal_title：Nature

authors： Thomas HE,Stunnenberg HG,Stewart AF

更新日期：1993-04-01 00:00:00

abstract：:When a portrait is coarsely quantized into blocks, the block structure hides the face, although lower spatial frequencies of the original image sufficient by themselves for recognition are preserved. Recognition can be recovered by blurring the image, or otherwise attenuating the spurious higher spatial frequency comp...

journal_title：Nature

authors： Morrone MC,Burr DC,Ross J

更新日期：1983-09-15 00:00:00

abstract：:Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 t...

journal_title：Nature

authors： Santamaría D,Barrière C,Cerqueira A,Hunt S,Tardy C,Newton K,Cáceres JF,Dubus P,Malumbres M,Barbacid M

更新日期：2007-08-16 00:00:00

abstract：:The ability to confine and store optical energy in small volumes has implications in fields ranging from cavity quantum electrodynamics to photonics. Of all cavity geometries, micrometre-sized dielectric spherical resonators are the best in terms of their ability to store energy for long periods of time within small v...

journal_title：Nature

authors： Spillane SM,Kippenberg TJ,Vahala KJ

更新日期：2002-02-07 00:00:00

abstract：:Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...

journal_title：Nature

authors： Maruŝić-Galesić S,Stephany DA,Longo DL,Kruisbeek AM

更新日期：1988-05-12 00:00:00

abstract：:The application of a sufficiently strong magnetic field to a superconductor will, in general, destroy the superconducting state. Two mechanisms are responsible for this. The first is the Zeeman effect, which breaks apart the paired electrons if they are in a spin-singlet (but not a spin-triplet) state. The second is t...

journal_title：Nature

authors： Uji S,Shinagawa H,Terashima T,Yakabe T,Terai Y,Tokumoto M,Kobayashi A,Tanaka H,Kobayashi H

更新日期：2001-04-19 00:00:00

abstract：:The intracellular pathogen Legionella pneumophila modulates the activity of host GTPases to direct the transport and assembly of the membrane-bound compartment in which it resides. In vitro studies have indicated that the Legionella protein DrrA post-translationally modifies the GTPase Rab1 by a process called AMPylat...

journal_title：Nature

authors： Mukherjee S,Liu X,Arasaki K,McDonough J,Galán JE,Roy CR

更新日期：2011-08-07 00:00:00

abstract：:The reversal or displacement of the retinal image by prism spectacles leads to extreme disruption of visually guided behaviour, but after an extended period of visual transformation normal behaviour is gradually restored. It is unclear whether this adaptation involves a change in visual perception, the learning of new...

journal_title：Nature

authors： Sugita Y

更新日期：1996-04-11 00:00:00

abstract：:Evolutionary adaptation can be rapid and potentially help species counter stressful conditions or realize ecological opportunities arising from climate change. The challenges are to understand when evolution will occur and to identify potential evolutionary winners as well as losers, such as species lacking adaptive c...

journal_title：Nature

authors： Hoffmann AA,Sgrò CM

更新日期：2011-02-24 00:00:00

abstract：:The U6 small nuclear (sn)RNA gene (SNR6) from the yeast Saccharomyces cerevisiae is transcribed by RNA polymerase III in vivo. This gene is unusual in having a TATA box at position -30, and an essential B-block element located downstream of the T-rich termination signal. The B block is one of the two intragenic promot...

journal_title：Nature

authors： Burnol AF,Margottin F,Huet J,Almouzni G,Prioleau MN,Méchali M,Sentenac A

更新日期：1993-04-01 00:00:00

abstract：:Interchromosomal gene conversion between alleles has been shown in yeast frequently to be associated with the recombination of flanking genetic markers. Although this also holds true for gene conversion between two alleles of the yeast mating-type (MAT) locus, initiated by the homothallic switching system, we find no ...

journal_title：Nature

authors： Klar AJ,Strathern JN

更新日期：1984-08-30 00:00:00

abstract：:B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the 'BCR repertoire'. Our understanding of the BCR repertoire in the con...

journal_title：Nature

authors： Bashford-Rogers RJM,Bergamaschi L,McKinney EF,Pombal DC,Mescia F,Lee JC,Thomas DC,Flint SM,Kellam P,Jayne DRW,Lyons PA,Smith KGC

更新日期：2019-10-01 00:00:00

abstract：:Highly collimated parsec-scale jets, which are generally linked to the presence of an accretion disk, are commonly observed in low-mass young stellar objects. In the past two decades, a few of these jets have been directly (or indirectly) observed from higher-mass (larger than eight solar masses) young stellar objects...

journal_title：Nature

authors： McLeod AF,Reiter M,Kuiper R,Klaassen PD,Evans CJ

更新日期：2018-02-15 00:00:00

abstract：:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region,...

journal_title：Nature

authors： Foster J,Stafford J,Queen C

更新日期：1985-05-30 00:00:00

abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...

journal_title：Nature

authors： Neumann CA,Krause DS,Carman CV,Das S,Dubey DP,Abraham JL,Bronson RT,Fujiwara Y,Orkin SH,Van Etten RA

更新日期：2003-07-31 00:00:00

abstract：:The classical view of fast chemical synaptic transmission is that released neurotransmitter acts locally on postsynaptic receptors and is cleared from the synaptic cleft within a few milliseconds by diffusion and by specific reuptake mechanisms. This rapid clearance restricts the spread of neurotransmitter and, combin...

journal_title：Nature

authors： Scanziani M,Salin PA,Vogt KE,Malenka RC,Nicoll RA

更新日期：1997-02-13 00:00:00

abstract：:Over 50% of patients who survive neuroinvasive infection with West Nile virus (WNV) exhibit chronic cognitive sequelae. Although thousands of cases of WNV-mediated memory dysfunction accrue annually, the mechanisms responsible for these impairments are unknown. The classical complement cascade, a key component of inna...

journal_title：Nature

authors： Vasek MJ,Garber C,Dorsey D,Durrant DM,Bollman B,Soung A,Yu J,Perez-Torres C,Frouin A,Wilton DK,Funk K,DeMasters BK,Jiang X,Bowen JR,Mennerick S,Robinson JK,Garbow JR,Tyler KL,Suthar MS,Schmidt RE,Stevens B,Klein

更新日期：2016-06-23 00:00:00

abstract：:The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by ...

journal_title：Nature

authors： Russo AA,Jeffrey PD,Patten AK,Massagué J,Pavletich NP

更新日期：1996-07-25 00:00:00

abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...

journal_title：Nature

authors： Catalan G,Scott JF

更新日期：2007-08-23 00:00:00

abstract：:In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to both sides of the brain. Having bilateral rather than unilateral projections may represent a useful redundancy. However, bilateral ORN projections to the brain should also compromise the ability to lateralize odours. Nevertheless, ...

journal_title：Nature

authors： Gaudry Q,Hong EJ,Kain J,de Bivort BL,Wilson RI

更新日期：2013-01-17 00:00:00

abstract：:Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

journal_title：Nature

authors： Coleman SW,Patricelli GL,Borgia G

更新日期：2004-04-15 00:00:00

abstract：:Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...

journal_title：Nature

authors： Naylor SL,Johnson BE,Minna JD,Sakaguchi AY

更新日期：1987-10-01 00:00:00

abstract：:Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services. Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels. However, only a few studies have so far incorporated an explic...

journal_title：Nature

authors： Scherber C,Eisenhauer N,Weisser WW,Schmid B,Voigt W,Fischer M,Schulze ED,Roscher C,Weigelt A,Allan E,Bessler H,Bonkowski M,Buchmann N,Buscot F,Clement LW,Ebeling A,Engels C,Halle S,Kertscher I,Klein AM,Koller R,

更新日期：2010-11-25 00:00:00