Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys.

Abstract:

:Transection of a sensory nerve in adults results in profound abnormalities in sensory perception, even if the severed nerve is surgically repaired to facilitate accurate nerve regeneration. In marked contrast, fewer perceptual errors follow nerve transection and surgical repair in children. The basis for this superior recovery in children was unknown. Here we show that there is little or no topographic order in the median nerve to the hand after median nerve section and surgical repair in immature macaque monkeys. Remarkably, however, in the same animals the representation of the reinnervated hand in primary somatosensory cortex area (area 3b) is quite orderly. This indicates that there are mechanisms in the developing brain that can create cortical topography, despite disordered sensory inputs. Presumably the superior recovery of perceptual abilities after peripheral nerve transection in children depends on this restoration of somatotopy in the central sensory maps.

journal_name

Nature

journal_title

Nature

authors

Florence SL,Jain N,Pospichal MW,Beck PD,Sly DL,Kaas JH

doi

10.1038/381069a0

subject

Has Abstract

pub_date

1996-05-02 00:00:00

pages

69-71

issue

6577

eissn

0028-0836

issn

1476-4687

journal_volume

381

pub_type

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