Genome organization and transactivation of the human immunodeficiency virus type 2.

abstract：:The mutation brachypodism (bp) alters the length and number of bones in the limbs of mice but spares the axial skeleton. It illustrates the importance of specific genes in controlling the morphogenesis of individual skeletal elements in the tetrapod limb. We now report the isolation of three new members of the transfo...

journal_title：Nature

authors： Storm EE,Huynh TV,Copeland NG,Jenkins NA,Kingsley DM,Lee SJ

更新日期：1994-04-14 00:00:00

abstract：:Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapo...

journal_title：Nature

authors： Vandaele AC,Korablev O,Daerden F,Aoki S,Thomas IR,Altieri F,López-Valverde M,Villanueva G,Liuzzi G,Smith MD,Erwin JT,Trompet L,Fedorova AA,Montmessin F,Trokhimovskiy A,Belyaev DA,Ignatiev NI,Luginin M,Olsen KS,Baggi

更新日期：2019-04-01 00:00:00

abstract：:Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the...

journal_title：Nature

authors： Adams EJ,Karthaus WR,Hoover E,Liu D,Gruet A,Zhang Z,Cho H,DiLoreto R,Chhangawala S,Liu Y,Watson PA,Davicioni E,Sboner A,Barbieri CE,Bose R,Leslie CS,Sawyers CL

更新日期：2019-07-01 00:00:00

abstract：:Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two o...

journal_title：Nature

authors： Margueron R,Justin N,Ohno K,Sharpe ML,Son J,Drury WJ 3rd,Voigt P,Martin SR,Taylor WR,De Marco V,Pirrotta V,Reinberg D,Gamblin SJ

更新日期：2009-10-08 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the alpha beta T-cell antigen receptor (TCR). An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules, a family of non-polymorphic, beta ...

journal_title：Nature

authors： Beckman EM,Porcelli SA,Morita CT,Behar SM,Furlong ST,Brenner MB

更新日期：1994-12-15 00:00:00

abstract：:Sheep learn to recognize the odours of their lambs within two hours of giving birth, and this learning involves synaptic changes within the olfactory bulb. Specifically, mitral cells become increasingly responsive to the learned odour, which stimulates release of both glutamate and GABA (gamma-aminobutyric acid) neuro...

journal_title：Nature

authors： Kendrick KM,Guevara-Guzman R,Zorrilla J,Hinton MR,Broad KD,Mimmack M,Ohkura S

更新日期：1997-08-14 00:00:00

abstract：:Therizinosauroids are an enigmatic group of dinosaurs known mostly from the Cretaceous period of Asia, whose derived members are characterized by elongate necks, laterally expanded pelves, small, leaf-shaped teeth, edentulous rostra and mandibular symphyses that probably bore keratinized beaks. Although more than a do...

journal_title：Nature

authors： Kirkland JI,Zanno LE,Sampson SD,Clark JM,DeBlieux DD

更新日期：2005-05-05 00:00:00

abstract：: ...

journal_title：Nature

authors： Woolston C

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Cyranoski D

更新日期：2019-02-01 00:00:00

abstract：:When a portrait is coarsely quantized into blocks, the block structure hides the face, although lower spatial frequencies of the original image sufficient by themselves for recognition are preserved. Recognition can be recovered by blurring the image, or otherwise attenuating the spurious higher spatial frequency comp...

journal_title：Nature

authors： Morrone MC,Burr DC,Ross J

更新日期：1983-09-15 00:00:00

abstract：:Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ra...

journal_title：Nature

authors： Möröy T,Marchio A,Etiemble J,Trépo C,Tiollais P,Buendia MA

更新日期：1986-11-20 00:00:00

abstract：:The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...

journal_title：Nature

authors： Slaughter MM,Miller RF

更新日期：1985-03-07 00:00:00

abstract：:Major histocompatibility complex class II molecules and their peptide ligands show unusual interaction kinetics, with slow association and dissociation rates that yield an apparent equilibrium constant of approximately 10(-6)-10(-8) M (refs 1-5). However, there is evidence for a specific, rapidly formed, short-lived c...

journal_title：Nature

authors： Sadegh-Nasseri S,Stern LJ,Wiley DC,Germain RN

更新日期：1994-08-25 00:00:00

abstract：:The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...

journal_title：Nature

authors： Getzoff ED,Cabelli DE,Fisher CL,Parge HE,Viezzoli MS,Banci L,Hallewell RA

更新日期：1992-07-23 00:00:00

abstract：:Many-body systems in nature exhibit complexity and self-organization arising from seemingly simple laws. For example, the long-range Coulomb interaction between electrical charges has a simple form, yet is responsible for a plethora of bound states in matter, ranging from the hydrogen atom to complex biochemical struc...

journal_title：Nature

authors： Kaindl RA,Carnahan MA,Hägele D,Lövenich R,Chemla DS

更新日期：2003-06-12 00:00:00

abstract：:Replication of multipotential stem cells in long-term murine bone marrow cell culture is known to depend on the development of an adherent stromal cell layer. In these conditions, restricted haematopoietic progenitor cells have also been generated for up to several months1-3. However, maturation is observed only in th...

journal_title：Nature

authors： Wendling F,Shreeve MM,McLeod DL,Axelrad AA

更新日期：1983-10-13 00:00:00

abstract：:Control of protein synthesis is associated with changes in the ratio of intracellular Na+ to K+ in the cultured embryonic chick lens. Correlations of intracellular Na+/K+ ratios with crystallin synthesis and cataract formation in vitro suggest that the Na+/K+ ratio may have an important role in the regulation of prote...

journal_title：Nature

authors： Shinohara T,Piatigorsky J

更新日期：1977-12-01 00:00:00

abstract：:Receptors for excitatory amino acids in the mammalian central nervous system are classified into three major subtypes, ones which prefer N-methyl-D-aspartate (NMDA), quisqualate (QA), or kainate (KA) as type agonists respectively. These receptors are considered to mediate fast postsynaptic potentials by activating ion...

journal_title：Nature

authors： Sugiyama H,Ito I,Hirono C

更新日期：1987-02-05 00:00:00

abstract：:Explaining the large-scale diversity of soil organisms that drive biogeochemical processes-and their responses to environmental change-is critical. However, identifying consistent drivers of belowground diversity and abundance for some soil organisms at large spatial scales remains problematic. Here we investigate a m...

journal_title：Nature

authors： van der Linde S,Suz LM,Orme CDL,Cox F,Andreae H,Asi E,Atkinson B,Benham S,Carroll C,Cools N,De Vos B,Dietrich HP,Eichhorn J,Gehrmann J,Grebenc T,Gweon HS,Hansen K,Jacob F,Kristöfel F,Lech P,Manninger M,Martin J

更新日期：2018-06-01 00:00:00

abstract：:Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...

journal_title：Nature

authors： Woychik RP,Maas RL,Zeller R,Vogt TF,Leder P

更新日期：1990-08-30 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...

journal_title：Nature

authors： Anneser L,Alcantara IC,Gemmer A,Mirkes K,Ryu S,Schuman EM

更新日期：2020-12-01 00:00:00

abstract：:The hypothesis that animal population dynamics may be synchronized by climate is highly relevant in the context of climate change because it suggests that several populations might respond simultaneously to climatic trends if their dynamics are entrained by environmental correlation. The dynamics of many species throu...

journal_title：Nature

authors： Post E,Forchhammer MC

更新日期：2002-11-14 00:00:00

abstract：:In Drosophila melanogaster, the rRNA genes (rDNA) are clustered at single sites on two non-homologous chromosomes, the X and Y. Examination of the structure of X and Y rDNAs with restriction endonucleases reveals that the X rDNA contains repeating units not present in the Y. Such observations, as well as genetic evide...

journal_title：Nature

authors： Tartof KD,Dawid IG

更新日期：1976-09-02 00:00:00

abstract：:Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...

journal_title：Nature

authors： Kessels HW,Nguyen LN,Nabavi S,Malinow R

更新日期：2010-08-12 00:00:00

abstract：:The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation and in tumorigenesis. The structures of Cdk6 bound to p16INK4a and to the related p19INK4d reveal that the INK4 inhibitors bind next t...

journal_title：Nature

authors： Russo AA,Tong L,Lee JO,Jeffrey PD,Pavletich NP

更新日期：1998-09-17 00:00:00

abstract：:Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...

journal_title：Nature

authors： Dupret V,Sanchez S,Goujet D,Tafforeau P,Ahlberg PE

更新日期：2014-03-27 00:00:00

abstract：:Group I and II introns are mobile elements that propagate by insertion into different genes. Some introns of both types self-splice in vitro by transesterification reactions catalysed by the intron RNA. These transesterifications are reversible, and it has been suggested that reverse splicing followed by reverse trans...

journal_title：Nature

authors： Mohr G,Lambowitz AM

更新日期：1991-11-14 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00