Abstract:
:Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both in Drosophila and vertebrates; the ventral region of Drosophila is homologous to the dorsal side of the vertebrate. Developmental studies are now revealing some of the characteristics of the ancestral animal that gave rise to the arthropod and mammalian lineages, for which we propose the name Urbilateria.
journal_name
Naturejournal_title
Natureauthors
De Robertis EM,Sasai Ydoi
10.1038/380037a0subject
Has Abstractpub_date
1996-03-07 00:00:00pages
37-40issue
6569eissn
0028-0836issn
1476-4687journal_volume
380pub_type
杂志文章相关文献
NATURE文献大全abstract::The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a libra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02033
更新日期:2003-10-30 00:00:00
abstract::The exceptionally broad species diversity of vascular plant genera in east Asian temperate forests, compared with their sister taxa in North America, has been attributed to the greater climatic diversity of east Asia, combined with opportunities for allopatric speciation afforded by repeated fragmentation and coalesce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35093166
更新日期:2001-09-13 00:00:00
abstract::Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorph...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322173a0
更新日期:1986-07-10 00:00:00
abstract::The most unique feature of Earth is the existence of life, and the most extraordinary feature of life is its diversity. Approximately 9 million types of plants, animals, protists and fungi inhabit the Earth. So, too, do 7 billion people. Two decades ago, at the first Earth Summit, the vast majority of the world's nati...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature11148
更新日期:2012-06-06 00:00:00
abstract::An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell line...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/270301a0
更新日期:1977-11-24 00:00:00
abstract::Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20598
更新日期:2016-12-15 00:00:00
abstract::Visual stimuli can acquire positive or negative value through their association with rewards and punishments, a process called reinforcement learning. Although we now know a great deal about how the brain analyses visual information, we know little about how visual representations become linked with values. To study t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04490
更新日期:2006-02-16 00:00:00
abstract::The Gulf Stream transports large amounts of heat from the tropics to middle and high latitudes, and thereby affects weather phenomena such as cyclogenesis and low cloud formation. But its climatic influence, on monthly and longer timescales, remains poorly understood. In particular, it is unclear how the warm current ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06690
更新日期:2008-03-13 00:00:00
abstract::NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01497
更新日期:2003-03-20 00:00:00
abstract::Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely u...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10656
更新日期:2011-11-27 00:00:00
abstract::Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14141
更新日期:2015-05-07 00:00:00
abstract::Called the "mystery of mysteries" by Darwin, speciation is still a little-understood area of evolution. Genetic analysis, however, has yielded new generalizations about speciation and suggests promising avenues of research. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355511a0
更新日期:1992-02-06 00:00:00
abstract::Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/318377a0
更新日期:1985-11-28 00:00:00
abstract::HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread? ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/455609a
更新日期:2008-10-02 00:00:00
abstract::Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/228258a0
更新日期:1970-10-17 00:00:00
abstract::L-GLUTAMATE and L-aspartate are thought to have a widespread function as synaptic transmitters in the mammalian central nervous system and there are at least three types of neuronal glutamate receptors, which can be activated by the selective agonists N-methyl-D-aspartate (NMDA), quisqualate and kainate. Recent experi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339380a0
更新日期:1989-06-01 00:00:00
abstract::Cells operate in dynamic environments using extraordinary communication capabilities that emerge from the interactions of genetic circuitry. The mammalian immune response is a striking example of the coordination of different cell types. Cell-to-cell communication is primarily mediated by signalling molecules that for...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09145
更新日期:2010-07-08 00:00:00
abstract::What is it that defines an animal? The definition provided here, made on the basis of developmental biology, suggests methods for resolving phylogenetic problems. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/361490a0
更新日期:1993-02-11 00:00:00
abstract::In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome1,2. However, the contribution of spatial genome organization to the regulation of developmental programs is unclear3. Here we generate high-resolution maps of genomic interactions wit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1233-0
更新日期:2019-05-01 00:00:00
abstract::Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02191
更新日期:2003-12-11 00:00:00
abstract::Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379346a0
更新日期:1996-01-25 00:00:00
abstract::In this Letter, a citation to 'Fig. 1e' has been corrected to 'Fig. 1d' in the sentence starting "By contrast, the anti-tumour response…". This has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1046-1
更新日期:2019-04-01 00:00:00
abstract::Certain cell fate decisions are specified by cell-cell interactions during the development of the nematode Caenorhabditis elegans. For example, in a wild-type hermaphrodite gonad, two cells, Z1.ppp and Z4.aaa, have the potential to become the anchor cell (AC). Intercellular communication establishes their fates and en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346197a0
更新日期:1990-07-12 00:00:00
abstract::How environmental cues regulate adult stem cell and cancer cell activity through surface receptors is poorly understood. Angiopoietin-like proteins (ANGPTLs), a family of seven secreted glycoproteins, are known to support the activity of haematopoietic stem cells (HSCs) in vitro and in vivo. ANGPTLs also have importan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11095
更新日期:2012-05-30 00:00:00
abstract::To understand the mechanism of muscular contraction and its regulation by Ca2+ (ref. 3), it is important to know the arrangement and configuration of the myosin heads in the space between thin and thick filaments in relaxed muscle. This information is still lacking, mainly because the myosin reflections in the X-ray d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/302069a0
更新日期:1983-03-03 00:00:00
abstract::Much of our knowledge of galaxies comes from analysing the radiation emitted by their stars, which depends on the present number of each type of star in the galaxy. The present number depends on the stellar initial mass function (IMF), which describes the distribution of stellar masses when the population formed, and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10972
更新日期:2012-04-25 00:00:00
abstract::Photoreceptors of the vertebrate retina hyperpolarize in response to light. The hyperpolarization elicited by a brief flash is approximately ten times slower in rods than in cones of the same retina. We have examined the amplification and temporal properties of synaptic transfer of rod and cone signals to a common pos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/296862a0
更新日期:1982-04-29 00:00:00
abstract::Chronic electrical stimulation of the auditory nerve in patients with profound sensori-neural deafness is becoming increasingly routine. Therefore, it is important to understand more about the long-term consequences of this procedure. Hitherto, structural studies in animals after electrocochlear stimulation have conce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320065a0
更新日期:1986-03-06 00:00:00
abstract::Understanding the behaviour of the dielectric constant in ferroelectric thin films remains a challenging problem. These ferroelectric materials have high static dielectric constants, and so are important for their applications in high-storage-density capacitor structures such as dynamic random access memory (DRAM). Bu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35006023
更新日期:2000-03-23 00:00:00
abstract::Brood parasitism, where a brood of the parasitic species is fostered by the parents of another species, is well known among birds. In most cases, such offspring show a complete reliance upon their host parents for food, protection and warmth until their independence. In other vertebrate groups, however, such total dep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323058a0
更新日期:1986-09-04 00:00:00