The adult Drosophila posterior midgut is maintained by pluripotent stem cells.

Abstract:

:Vertebrate and invertebrate digestive systems show extensive similarities in their development, cellular makeup and genetic control. The Drosophila midgut is typical: enterocytes make up the majority of the intestinal epithelial monolayer, but are interspersed with hormone-producing enteroendocrine cells. Human (and mouse) intestinal cells are continuously replenished by stem cells, the misregulation of which may underlie some common digestive diseases and cancer. In contrast, stem cells have not been described in the intestines of flies, and Drosophila intestinal cells have been thought to be relatively stable. Here we use lineage labelling to show that adult Drosophila posterior midgut cells are continuously replenished by a distinctive population of intestinal stem cells (ISCs). As in vertebrates, ISCs are multipotent, and Notch signalling is required to produce an appropriate fraction of enteroendocrine cells. Notch is also required for the differentiation of ISC daughter cells, a role that has not been addressed in vertebrates. Unlike previously characterized stem cells, which reside in niches containing a specific partner stromal cell, ISCs adjoin only the basement membrane, differentiated enterocytes and their most recent daughters. The identification of Drosophila intestinal stem cells with striking similarities to their vertebrate counterparts will facilitate the genetic analysis of normal and abnormal intestinal function.

journal_name

Nature

journal_title

Nature

authors

Ohlstein B,Spradling A

doi

10.1038/nature04333

keywords:

subject

Has Abstract

pub_date

2006-01-26 00:00:00

pages

470-4

issue

7075

eissn

0028-0836

issn

1476-4687

pii

nature04333

journal_volume

439

pub_type

杂志文章

相关文献

NATURE文献大全
  • Spectroscopic confirmation of a galaxy at redshift z = 8.6.

    abstract::Galaxies had their most significant impact on the Universe when they assembled their first generations of stars. Energetic photons emitted by young, massive stars in primeval galaxies ionized the intergalactic medium surrounding their host galaxies, cleared sightlines along which the light of the young galaxies could ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09462

    authors: Lehnert MD,Nesvadba NP,Cuby JG,Swinbank AM,Morris S,Clément B,Evans CJ,Bremer MN,Basa S

    更新日期:2010-10-21 00:00:00

  • Structure and evolution of a human erythroid transcription factor.

    abstract::Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/343092a0

    authors: Trainor CD,Evans T,Felsenfeld G,Boguski MS

    更新日期:1990-01-04 00:00:00

  • Structural basis of the activation of a metabotropic GABA receptor.

    abstract::Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2408-4

    authors: Shaye H,Ishchenko A,Lam JH,Han GW,Xue L,Rondard P,Pin JP,Katritch V,Gati C,Cherezov V

    更新日期:2020-08-01 00:00:00

  • A general carbonyl alkylative amination for tertiary amine synthesis.

    abstract::The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination3, which compr...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2213-0

    authors: Kumar R,Flodén NJ,Whitehurst WG,Gaunt MJ

    更新日期:2020-05-01 00:00:00

  • TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

    abstract::Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of respon...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature25501

    authors: Mariathasan S,Turley SJ,Nickles D,Castiglioni A,Yuen K,Wang Y,Kadel EE III,Koeppen H,Astarita JL,Cubas R,Jhunjhunwala S,Banchereau R,Yang Y,Guan Y,Chalouni C,Ziai J,Şenbabaoğlu Y,Santoro S,Sheinson D,Hung J,Giltna

    更新日期:2018-02-22 00:00:00

  • Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.

    abstract::The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07763

    authors: Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

    更新日期:2009-04-02 00:00:00

  • Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.

    abstract::An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41586-019-1890-z

    authors: Momcilovic M,Jones A,Bailey ST,Waldmann CM,Li R,Lee JT,Abdelhady G,Gomez A,Holloway T,Schmid E,Stout D,Fishbein MC,Stiles L,Dabir DV,Dubinett SM,Christofk H,Shirihai O,Koehler CM,Sadeghi S,Shackelford DB

    更新日期:2020-01-01 00:00:00

  • Electric fish measure distance in the dark.

    abstract::Distance determination in animals can be achieved by visual or non-visual cues. Weakly electric fish use active electrolocation for orientation in the dark. By perceiving self-produced electric signals with epidermal electroreceptors, fish can detect, locate and analyse nearby objects. Distance discrimination, however...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/27655

    authors: von der Emde G,Schwarz S,Gomez L,Budelli R,Grant K

    更新日期:1998-10-29 00:00:00

  • Sampling the volatile-rich transition zone beneath Bermuda.

    abstract::Intraplate magmatic provinces found away from plate boundaries provide direct sampling of the composition and heterogeneity of the Earth's mantle. The chemical heterogeneities that have been observed in the mantle are usually attributed to recycling during subduction1-3, which allows for the addition of volatiles and ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1183-6

    authors: Mazza SE,Gazel E,Bizimis M,Moucha R,Béguelin P,Johnson EA,McAleer RJ,Sobolev AV

    更新日期:2019-05-01 00:00:00

  • A haplotype map of the human genome.

    abstract::Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples fro...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04226

    authors: International HapMap Consortium.

    更新日期:2005-10-27 00:00:00

  • DNA fingerprinting dispute laid to rest.

    abstract::Two principals in the once-raging debate over forensic DNA typing conclude that the scientific issues have all been resolved. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/371735a0

    authors: Lander ES,Budowle B

    更新日期:1994-10-27 00:00:00

  • Genomic analyses inform on migration events during the peopling of Eurasia.

    abstract::High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population hi...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature19792

    authors: Pagani L,Lawson DJ,Jagoda E,Mörseburg A,Eriksson A,Mitt M,Clemente F,Hudjashov G,DeGiorgio M,Saag L,Wall JD,Cardona A,Mägi R,Wilson Sayres MA,Kaewert S,Inchley C,Scheib CL,Järve M,Karmin M,Jacobs GS,Antao T,Ilie

    更新日期:2016-10-13 00:00:00

  • A network that learns to recognize three-dimensional objects.

    abstract::The visual recognition of three-dimensional (3-D) objects on the basis of their shape poses at least two difficult problems. First, there is the problem of variable illumination, which can be addressed by working with relatively stable features such as intensity edges rather than the raw intensity images. Second, ther...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/343263a0

    authors: Poggio T,Edelman S

    更新日期:1990-01-18 00:00:00

  • (Na/ + K+)ATPase has one functioning phosphorylation site per alpha subunit.

    abstract::(Na+ + K+)ATPase contains two different subunits, a catalytic subunit (alpha) and a subunit with uncertain function (beta). The enzyme binds ATP, ouabain and vanadate, and can be phosphorylated by ATP as well as by inorganic phosphate. From the previously reported maximal binding and phosphorylation capacities of 3.5-...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/290338a0

    authors: Peters WH,Swarts HG,de Pont JJ,Schuurmans Stekhoven FM,Bonting SL

    更新日期:1981-03-26 00:00:00

  • Birds have paedomorphic dinosaur skulls.

    abstract::The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of major vertebrate lineages such as mammals, including humans. Birds are the most speciose land verteb...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11146

    authors: Bhullar BA,Marugán-Lobón J,Racimo F,Bever GS,Rowe TB,Norell MA,Abzhanov A

    更新日期:2012-07-12 00:00:00

  • Immune recognition of a human renal cancer antigen through post-translational protein splicing.

    abstract::Cytotoxic T lymphocytes (CTLs) detect and destroy cells displaying class I molecules of the major histocompatibility complex (MHC) that present oligopeptides derived from aberrant self or foreign proteins. Most class I peptide ligands are created from proteins that are degraded by proteasomes and transported, by the t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02240

    authors: Hanada K,Yewdell JW,Yang JC

    更新日期:2004-01-15 00:00:00

  • Episodic fresh surface waters in the Eocene Arctic Ocean.

    abstract::It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55-45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding evaporation at high latitudes. Little f...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature04692

    authors: Brinkhuis H,Schouten S,Collinson ME,Sluijs A,Sinninghe Damsté JS,Dickens GR,Huber M,Cronin TM,Onodera J,Takahashi K,Bujak JP,Stein R,van der Burgh J,Eldrett JS,Harding IC,Lotter AF,Sangiorgi F,van Konijnenburg-van Citte

    更新日期:2006-06-01 00:00:00

  • Immune defence in bumble-bee offspring.

    abstract::Immune-challenged vertebrate females transfer specific antibodies to their offspring, but this gratuitous immunity cannot operate in invertebrates. Here we show that constitutive immune defence is enhanced in sexual offspring of the bumble-bee Bombus terrestris L. when the parental colony is immune-challenged. Our fin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35107138

    authors: Moret Y,Schmid-Hempel P

    更新日期:2001-11-29 00:00:00

  • Single-neuron perturbations reveal feature-specific competition in V1.

    abstract::The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity. Here we describe a method-influence mapping-that uses single-neuron perturbations to directly measure how cortical neurons reshape sensory represent...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-0997-6

    authors: Chettih SN,Harvey CD

    更新日期:2019-03-01 00:00:00

  • Guard cell abscisic acid signalling and engineering drought hardiness in plants.

    abstract::Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal tra...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/35066500

    authors: Schroeder JI,Kwak JM,Allen GJ

    更新日期:2001-03-15 00:00:00

  • Mechanical milling assisted by electrical discharge.

    abstract::Mechanical milling is an effective technique for the preparation of fine metallic and ceramic powders and can also be used to drive a wide range of chemical reactions. Milling devices include planetary machines, attritors and vibrational mills; products include amorphous, nanocrystalline and quasicrystalline materials...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature00985

    authors: Calka A,Wexler D

    更新日期:2002-09-12 00:00:00

  • Colombia creates its first science ministry.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-019-00087-z

    authors: Wight AJ

    更新日期:2019-01-01 00:00:00

  • Variable female preferences drive complex male displays.

    abstract::Complexity in male sexual displays is widely appreciated but diversity in female mate choice has received little attention. Males of many species have sexual displays composed of multiple display traits, and females are thought to use these different traits in mate choice. Models of multiple display trait evolution su...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02419

    authors: Coleman SW,Patricelli GL,Borgia G

    更新日期:2004-04-15 00:00:00

  • Functional diversification of closely related ARF-GEFs in protein secretion and recycling.

    abstract::Guanine-nucleotide exchange factors on ADP-ribosylation factor GTPases (ARF-GEFs) regulate vesicle formation in time and space by activating ARF substrates on distinct donor membranes. Mammalian GBF1 (ref. 2) and yeast Gea1/2 (ref. 3) ARF-GEFs act at Golgi membranes, regulating COPI-coated vesicle formation. In contra...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05967

    authors: Richter S,Geldner N,Schrader J,Wolters H,Stierhof YD,Rios G,Koncz C,Robinson DG,Jürgens G

    更新日期:2007-07-26 00:00:00

  • Cloning of bovine GAP and its interaction with oncogenic ras p21.

    abstract::The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/335090a0

    authors: Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

    更新日期:1988-09-01 00:00:00

  • SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

    abstract::Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12618

    authors: Shcheglovitov A,Shcheglovitova O,Yazawa M,Portmann T,Shu R,Sebastiano V,Krawisz A,Froehlich W,Bernstein JA,Hallmayer JF,Dolmetsch RE

    更新日期:2013-11-14 00:00:00

  • Kondo resonance in a single-molecule transistor.

    abstract::When an individual molecule, nanocrystal, nanotube or lithographically defined quantum dot is attached to metallic electrodes via tunnel barriers, electron transport is dominated by single-electron charging and energy-level quantization. As the coupling to the electrodes increases, higher-order tunnelling and correlat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature00790

    authors: Liang W,Shores MP,Bockrath M,Long JR,Park H

    更新日期:2002-06-13 00:00:00

  • Cholinergic neurones acquire adrenergic neurotransmitters when transplanted into an embryo.

    abstract::During development, cells become progressively restricted, until they reach their final phenotype. Differentiation was originally thought to be irreversible, but phenotypic plasticity has been observed in a variety of cell types, for example sympathetic neurones, the limb blastema and some glial cell types. A detailed...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/324569a0

    authors: Coulombe JN,Bronner-Fraser M

    更新日期:1986-12-11 00:00:00

  • Changes in the phase of the annual cycle of surface temperature.

    abstract::The annual cycle in the Earth's surface temperature is extremely large-comparable in magnitude to the glacial-interglacial cycles over most of the planet. Trends in the phase and the amplitude of the annual cycle have been observed, but the causes and significance of these changes remain poorly understood-in part beca...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07675

    authors: Stine AR,Huybers P,Fung IY

    更新日期:2009-01-22 00:00:00

  • Defining brain wiring patterns and mechanisms through gene trapping in mice.

    abstract::The search to understand the mechanisms regulating brain wiring has relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular cues and receptors for axon guidance. Here we describe a phenotype-based gene-trap screen in mice designed for the large-scale i...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35065539

    authors: Leighton PA,Mitchell KJ,Goodrich LV,Lu X,Pinson K,Scherz P,Skarnes WC,Tessier-Lavigne M

    更新日期:2001-03-08 00:00:00