Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain.

abstract：:Neurons develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures. Among MAPs, MAP2 is specifically expressed in dendrites whereas MAP2C and tau are abundant in the axon. But the...

journal_title：Nature

authors： Chen J,Kanai Y,Cowan NJ,Hirokawa N

更新日期：1992-12-17 00:00:00

abstract：:Current ideas about the dependence of neurons on target-derived growth factors were formulated on the basis of experiments involving neurons with projections to the periphery. Nerve growth factor (NGF) and recently identified members of the NGF family of neuronal growth factors, known as neurotrophins, are thought to ...

journal_title：Nature

authors： Yan Q,Elliott J,Snider WD

更新日期：1992-12-24 00:00:00

abstract：:Human behaviour is thought to spread through face-to-face social networks, but it is difficult to identify social influence effects in observational studies, and it is unknown whether online social networks operate in the same way. Here we report results from a randomized controlled trial of political mobilization mes...

journal_title：Nature

authors： Bond RM,Fariss CJ,Jones JJ,Kramer AD,Marlow C,Settle JE,Fowler JH

更新日期：2012-09-13 00:00:00

abstract：:Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will p...

journal_title：Nature

authors： Hay JC,Fisette PL,Jenkins GH,Fukami K,Takenawa T,Anderson RA,Martin TF

更新日期：1995-03-09 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:The chemical composition of basaltic magma erupted at the Earth's surface is the end product of a complex series of processes, beginning with partial melting and melt extraction from a mantle source and ending with fractional crystallization and crustal assimilation at lower pressures. It has been proposed that studyi...

journal_title：Nature

authors： Spandler C,O'Neill HS,Kamenetsky VS

更新日期：2007-05-17 00:00:00

abstract：:Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and ...

journal_title：Nature

authors： Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM

更新日期：2005-08-18 00:00:00

abstract：:An Amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Schwörer S,Becker F,Feller C,Baig AH,Köber U,Henze H,Kraus JM,Xin B,Lechel A,Lipka DB,Varghese CS,Schmidt M,Rohs R,Aebersold R,Medina KL,Kestler HA,Neri F,von Maltzahn J,Tümpel S,Rudolph KL

更新日期：2019-08-01 00:00:00

abstract：:Low-resolution intensity spectra of Earth's atmosphere obtained from space reveal strong signatures of life ('biosignatures'), such as molecular oxygen and methane with abundances far from chemical equilibrium, as well as the presence of a 'red edge' (a sharp increase of albedo for wavelengths longer than 700 nm) caus...

journal_title：Nature

authors： Sterzik MF,Bagnulo S,Palle E

更新日期：2012-02-29 00:00:00

abstract：:Integral membrane proteins are encoded by approximately 25% of all protein-coding genes1. In eukaryotes, the majority of membrane proteins are inserted, modified and folded at the endoplasmic reticulum (ER)2. Research over the past several decades has determined how membrane proteins are targeted to the ER and how ind...

journal_title：Nature

authors： Chitwood PJ,Hegde RS

更新日期：2020-08-01 00:00:00

abstract：:A plume of water vapour escapes from fissures crossing the south polar region of the Saturnian moon Enceladus. Tidal deformation of a thin surface crust above an internal ocean could result in tensile and compressive stresses that would affect the width of the fissures; therefore, the quantity of water vapour released...

journal_title：Nature

authors： Hansen CJ,Esposito LW,Stewart AI,Meinke B,Wallis B,Colwell JE,Hendrix AR,Larsen K,Pryor W,Tian F

更新日期：2008-11-27 00:00:00

abstract：:Drosophila cells contain virus-like particles (VLPs) containing 5 kilobases (kb) of RNA (VLP H-RNA) homologous to the transposable element copia. The identity between VLP H-RNA and copia DNA has previously been confirmed at the nucleotide sequence level and reverse transcriptase activity is also detected in the VLPs. ...

journal_title：Nature

authors： Kikuchi Y,Ando Y,Shiba T

更新日期：1986-10-30 00:00:00

abstract：:ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by...

journal_title：Nature

authors： Pebay-Peyroula E,Dahout-Gonzalez C,Kahn R,Trézéguet V,Lauquin GJ,Brandolin G

更新日期：2003-11-06 00:00:00

abstract：:Normal cellular function requires that organelles be positioned in specific locations. The direction in which molecular motors move organelles is based in part on the polarity of microtubules and actin filaments. However, this alone does not determine the intracellular destination of organelles. For example, the yeast...

journal_title：Nature

authors： Tang F,Kauffman EJ,Novak JL,Nau JJ,Catlett NL,Weisman LS

更新日期：2003-03-06 00:00:00

abstract：:Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...

journal_title：Nature

authors： Jin R,Cao YC,Hao E,Métraux GS,Schatz GC,Mirkin CA

更新日期：2003-10-02 00:00:00

abstract：:At fertilization, an increase of cytosolic calcium ions (Ca2+) triggers various activation responses in animal eggs. In vertebrates, these responses include exit from metaphase arrest in meiosis II (MII exit) and cortical remodelling initiated by cortical granule exocytosis. Although the essential requirement of Ca2+/...

journal_title：Nature

authors： Nishiyama T,Yoshizaki N,Kishimoto T,Ohsumi K

更新日期：2007-09-20 00:00:00

abstract：:Stable maintenance of gene regulatory programs is essential for normal function in multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are hypothesized to facilitate such maintenance by creating cellular memory that can be written during embryonic development and then guide cell-type-spe...

journal_title：Nature

authors： Shipony Z,Mukamel Z,Cohen NM,Landan G,Chomsky E,Zeliger SR,Fried YC,Ainbinder E,Friedman N,Tanay A

更新日期：2014-09-04 00:00:00

abstract：:In animals, maternal gene products deposited into eggs regulate embryonic development before activation of the zygotic genome. In plants, an analogous period of prolonged maternal control over embryogenesis is thought to occur based on some gene-expression studies. However, other gene-expression studies and genetic an...

journal_title：Nature

authors： Nodine MD,Bartel DP

更新日期：2012-01-22 00:00:00

abstract：:As the extracellular matrix at the original site of a neuromuscular junction seems to play a major part in the specificity of synaptic regeneration, considerable attention has been paid to unique molecules localized to this region. Here we describe an extracellular matrix glycoprotein of the elasmobranch electric orga...

journal_title：Nature

authors： Caroni P,Carlson SS,Schweitzer E,Kelly RB

更新日期：1985-04-04 00:00:00

abstract：:The enzyme complex nitrogenase, which reduces N2 to NH+4, involves two redox proteins, both irreversibly damaged by O2 (ref. 1). Enzyme activity therefore requires anaerobic conditions, a source of reductant and a large amount of ATP (approximately 16 ATPs per N2). In both aerobic and facultative anaerobic N2-fixing b...

journal_title：Nature

authors： Hill S,Kennedy C,Kavanagh E,Goldberg RB,Hanau R

更新日期：1981-04-02 00:00:00

abstract：:Spontaneous symmetry breaking plays a key role in our understanding of nature. In relativistic quantum field theory, a broken continuous symmetry leads to the emergence of two types of fundamental excitation: massless Nambu-Goldstone modes and a massive 'Higgs' amplitude mode. An excitation of Higgs type is of crucial...

journal_title：Nature

authors： Endres M,Fukuhara T,Pekker D,Cheneau M,Schauss P,Gross C,Demler E,Kuhr S,Bloch I

更新日期：2012-07-25 00:00:00

abstract：:Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...

journal_title：Nature

authors： Bedo G,Santisteban P,Aranda A

更新日期：1989-05-18 00:00:00

abstract：:The rapid turnover of the mammalian intestinal epithelium is supported by stem cells located around the base of the crypt. In addition to the Lgr5 marker, intestinal stem cells have been associated with other markers that are expressed heterogeneously within the crypt base region. Previous quantitative clonal fate ana...

journal_title：Nature

authors： Ritsma L,Ellenbroek SIJ,Zomer A,Snippert HJ,de Sauvage FJ,Simons BD,Clevers H,van Rheenen J

更新日期：2014-03-20 00:00:00

abstract：: ...

journal_title：Nature

authors： Narayan A

更新日期：2019-03-01 00:00:00

abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...

journal_title：Nature

authors： Cronin TW,Caldwell RL,Marshall J

更新日期：2001-05-31 00:00:00

abstract：:During the evolution of sea urchins, a transfer RNA gene lost its tRNA function and became part of a protein-coding gene. This functional loss of a tRNA with specificity for one group of leucine codons (CUN, where N is any base) was accompanied by the gain of a new tRNA with that specificity. The new tRNA gene for CUN...

journal_title：Nature

authors： Cantatore P,Gadaleta MN,Roberti M,Saccone C,Wilson AC

更新日期：1987-10-29 00:00:00

abstract：:Primordial germ cells (PGCs) are first identifiable as a population of about eight alkaline phosphatase-positive cells in the 7.0 days postcoitum mouse embryo. During the next 6 days of development they proliferate to give rise to the 25,000 cells that will establish the meiotic population. Steel factor is required fo...

journal_title：Nature

authors： Resnick JL,Bixler LS,Cheng L,Donovan PJ

更新日期：1992-10-08 00:00:00

abstract：:Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...

journal_title：Nature

authors： Sakamaki T,Suzuki A,Ohtani E

更新日期：2006-01-12 00:00:00

abstract：:The radiation of the mammals provides a 165-million-year test case for evolutionary theories of how species occupy and then fill ecological niches. It is widely assumed that species often diverge rapidly early in their evolution, and that this is followed by a longer, drawn-out period of slower evolutionary fine-tunin...

journal_title：Nature

authors： Venditti C,Meade A,Pagel M

更新日期：2011-10-19 00:00:00

abstract：:A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...

journal_title：Nature

authors： Graf T,Ade N,Beug H

更新日期：1978-10-12 00:00:00