Unusual priming mechanism of RNA-directed DNA synthesis in copia retrovirus-like particles of Drosophila.

abstract：:Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....

journal_title：Nature

authors： Zhao Y,Huang G,Wu Q,Wu K,Li R,Lei J,Pan X,Yan N

更新日期：2019-12-01 00:00:00

abstract：:Ultrafast time-resolved optical spectroscopy has revealed new classes of physical, chemical and biological reactions, in which directed, deterministic motions of atoms have a key role. This contrasts with the random, diffusive motion of atoms across activation barriers that typically determines kinetic rates on slower...

journal_title：Nature

authors： Rousse A,Rischel C,Fourmaux S,Uschmann I,Sebban S,Grillon G,Balcou P,Förster E,Geindre JP,Audebert P,Gauthier JC,Hulin D

更新日期：2001-03-01 00:00:00

abstract：:Bird songs frequently contain trilling sounds that demand extremely fast vocalization control. Here we show that doves control their syrinx, a vocal organ that is unique to birds, by using superfast muscles. These muscles, which are similar to those that operate highly specialist acoustic organs such as the rattle of ...

journal_title：Nature

authors： Elemans CP,Spierts IL,Müller UK,Van Leeuwen JL,Goller F

更新日期：2004-09-09 00:00:00

abstract：:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...

journal_title：Nature

authors： Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

更新日期：1991-10-10 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte. This localization requires several trans-acting factors, including Barentsz and the Mago-Y14 heterodimer, which assemble with oskar mRNA into ribonucleoprotein particles ...

journal_title：Nature

authors： Palacios IM,Gatfield D,St Johnston D,Izaurralde E

更新日期：2004-02-19 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00

abstract：:Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...

journal_title：Nature

authors： Kessels HW,Nguyen LN,Nabavi S,Malinow R

更新日期：2010-08-12 00:00:00

abstract：:The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing m...

journal_title：Nature

authors： Bourdeau RW,Lee-Gosselin A,Lakshmanan A,Farhadi A,Kumar SR,Nety SP,Shapiro MG

更新日期：2018-01-03 00:00:00

abstract：:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New a...

journal_title：Nature

authors： Barker RA,Götz M,Parmar M

更新日期：2018-05-01 00:00:00

abstract：:Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...

journal_title：Nature

authors： Ebers GC,Sadovnick AD,Risch NJ

更新日期：1995-09-14 00:00:00

abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...

journal_title：Nature

authors： Shakeel S,Rajendra E,Alcón P,O'Reilly F,Chorev DS,Maslen S,Degliesposti G,Russo CJ,He S,Hill CH,Skehel JM,Scheres SHW,Patel KJ,Rappsilber J,Robinson CV,Passmore LA

更新日期：2019-11-01 00:00:00

abstract：:The Earth's equatorial stratosphere shows oscillations in which the east-west winds reverse direction and the temperatures change cyclically with a period of about two years. This phenomenon, called the quasi-biennial oscillation, also affects the dynamics of the mid- and high-latitude stratosphere and weather in the ...

journal_title：Nature

authors： Flasar FM,Kunde VG,Achterberg RK,Conrath BJ,Simon-Miller AA,Nixon CA,Gierasch PJ,Romani PN,Bézard B,Irwin P,Bjoraker GL,Brasunas JC,Jennings DE,Pearl JC,Smith MD,Orton GS,Spilker LJ,Carlson R,Calcutt SB,Read PL,Ta

更新日期：2004-01-08 00:00:00

abstract：:It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer d...

journal_title：Nature

authors： Papitto A,Ferrigno C,Bozzo E,Rea N,Pavan L,Burderi L,Burgay M,Campana S,Di Salvo T,Falanga M,Filipović MD,Freire PC,Hessels JW,Possenti A,Ransom SM,Riggio A,Romano P,Sarkissian JM,Stairs IH,Stella L,Torres DF,Wi

更新日期：2013-09-26 00:00:00

abstract：:One hundred years ago Albert Einstein introduced the concept of the photon. Although in the early years after 1905 the evidence for the quantum nature of light was not compelling, modern experiments--especially those using photon pairs--have beautifully confirmed its corpuscular character. Research on the quantum prop...

journal_title：Nature

authors： Zeilinger A,Weihs G,Jennewein T,Aspelmeyer M

更新日期：2005-01-20 00:00:00

abstract：:Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...

journal_title：Nature

authors： Qian H,Kang X,Hu J,Zhang D,Liang Z,Meng F,Zhang X,Xue Y,Maimon R,Dowdy SF,Devaraj NK,Zhou Z,Mobley WC,Cleveland DW,Fu XD

更新日期：2020-06-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...

journal_title：Nature

authors：

更新日期：1992-04-02 00:00:00

abstract：:When an intense laser pulse is focused into a gas, the light-atom interaction that occurs as atoms are ionized results in an extremely nonlinear optical process--the generation of high harmonics of the driving laser frequency. Harmonics that extend up to orders of about 300 have been reported, some corresponding to ph...

journal_title：Nature

authors： Bartels R,Backus S,Zeek E,Misoguti L,Vdovin G,Christov IP,Murnane MM,Kapteyn HC

更新日期：2000-07-13 00:00:00

abstract：:Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...

journal_title：Nature

authors： Anderson RM,May RM,McLean AR

更新日期：1988-03-17 00:00:00

abstract：:BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from many eukaryotic promoters in gene expression. Regulation of this binding is therefore likely to be an important determinant of promoter activity. Incorporation of the TATA sequence into nucleosomes dramatically reduces transcr...

journal_title：Nature

authors： Imbalzano AN,Kwon H,Green MR,Kingston RE

更新日期：1994-08-11 00:00:00

abstract：:Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to produce mono-, di- and trihydroxyeicosatetraenoic acids (HETEs). Polymorphonuclear leukocytes (PMNs) release HETEs, including mono- and dihydroxy fatty acids, when exposed to stimuli such as the ...

journal_title：Nature

authors： Ford-Hutchinson AW,Bray MA,Doig MV,Shipley ME,Smith MJ

更新日期：1980-07-17 00:00:00

abstract：:Chick embryo fibroblasts (CEF) infected with avian sarcoma virus become rapidly transformed as a result of expression of the viral src gene in the form of a single polypeptide of molecular weight 60,000 (pp60src) with protein kinase activity and suggested preferential association with the plasma membrane. Studies with...

journal_title：Nature

authors： Witt DP,Gordon JA

更新日期：1980-09-18 00:00:00

abstract：:Oxygen, one of the most abundant elements on Earth, often forms an undesired interstitial impurity or ceramic phase (such as an oxide particle) in metallic materials. Even when it adds strength, oxygen doping renders metals brittle1-3. Here we show that oxygen can take the form of ordered oxygen complexes, a state in ...

journal_title：Nature

authors： Lei Z,Liu X,Wu Y,Wang H,Jiang S,Wang S,Hui X,Wu Y,Gault B,Kontis P,Raabe D,Gu L,Zhang Q,Chen H,Wang H,Liu J,An K,Zeng Q,Nieh TG,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:The genes for the T-cell receptor, like the immunoglobulin genes, are rearranged as DNA. The mechanism of this rearrangement is not clear; unequal crossover between chromosomes and the looping-out and excision of the excess DNA have both been suggested. We isolated small polydisperse circular (spc) DNAs from mouse thy...

journal_title：Nature

authors： Fujimoto S,Yamagishi H

更新日期：1987-05-21 00:00:00

abstract：:The central nervous system (CNS) requires a tightly controlled environment free of toxins and pathogens to provide the proper chemical composition for neural function. This environment is maintained by the 'blood-brain barrier' (BBB), which is composed of blood vessels whose endothelial cells display specialized tight...

journal_title：Nature

authors： Ben-Zvi A,Lacoste B,Kur E,Andreone BJ,Mayshar Y,Yan H,Gu C

更新日期：2014-05-22 00:00:00

abstract：:Local galaxies are broadly divided into two main classes, star-forming (gas-rich) and quiescent (passive and gas-poor). The primary mechanism responsible for quenching star formation in galaxies and transforming them into quiescent and passive systems is still unclear. Sudden removal of gas through outflows or strippi...

journal_title：Nature

authors： Peng Y,Maiolino R,Cochrane R

更新日期：2015-05-14 00:00:00

abstract：:Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent sex chromosome orig...

journal_title：Nature

authors： Cortez D,Marin R,Toledo-Flores D,Froidevaux L,Liechti A,Waters PD,Grützner F,Kaessmann H

更新日期：2014-04-24 00:00:00

abstract：:Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...

journal_title：Nature

authors： Xiong Y,Steitz TA

更新日期：2004-08-05 00:00:00

abstract：:The average air temperature at the Earth's surface has increased by 0.06 degrees C per decade during the 20th century, and by 0.19 degrees C per decade from 1979 to 1998. Climate models generally predict amplified warming in polar regions, as observed in Antarctica's peninsula region over the second half of the 20th c...

journal_title：Nature

authors： Doran PT,Priscu JC,Lyons WB,Walsh JE,Fountain AG,McKnight DM,Moorhead DL,Virginia RA,Wall DH,Clow GD,Fritsen CH,McKay CP,Parsons AN

更新日期：2002-01-31 00:00:00