Abstract：
:The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, block membrane assembly, while insertion of three lysyl residues near the carboxy terminus partially restores assembly. Thus the information specifying membrane insertion of M13 procoat protein is found in its mature region as well as the leader and is not simply decoded in an amino to carboxy direction.
journal_name
Naturejournal_title
Natureauthors
Kuhn A,Wickner W,Kreil Gdoi
10.1038/322335a0subject
Has Abstractpub_date
1986-07-24 00:00:00pages
335-9issue
6077eissn
0028-0836issn
1476-4687journal_volume
322pub_type
杂志文章相关文献
NATURE文献大全abstract：:Recurring outbursts associated with matter flowing onto compact stellar remnants (such as black holes, neutron stars and white dwarfs) in close binary systems provide a way of constraining the poorly understood accretion process. The light curves of these outbursts are shaped by the efficiency of angular-momentum (and...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature25159
更新日期：2018-02-01 00:00:00
abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/290413a0
更新日期：1981-04-02 00:00:00
abstract：:Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease. To identify the target of these agents we developed biotinyla...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07055
更新日期：2008-06-12 00:00:00
abstract：:It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/313678a0
更新日期：1985-02-21 00:00:00
abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06468
更新日期：2008-01-10 00:00:00
abstract：:Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved difficult p...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35065604
更新日期：2001-03-08 00:00:00
abstract：:Plant respiration results in an annual flux of carbon dioxide (CO2) to the atmosphere that is six times as large as that due to the emissions from fossil fuel burning, so changes in either will impact future climate. As plant respiration responds positively to temperature, a warming world may result in additional resp...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature17142
更新日期：2016-03-31 00:00:00
abstract：:The cell adhesion molecules L1, N-CAM and Ng-CAM have been implicated in cell-cell interactions among developing neural cells. L1 and N-CAM are structurally and functionally distinct molecular entities and act synergistically in mediating Ca2+-independent adhesion between re-aggregating early postnatal cerebellar cell...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/316728a0
更新日期：1985-08-22 00:00:00
abstract：:Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10074
更新日期：2011-05-12 00:00:00
abstract：:Abscisic acid (ABA) is a vital phytohormone that regulates mainly stomatal aperture and seed development, but ABA receptors involved in these processes have yet to be determined. We previously identified from broad bean an ABA-binding protein (ABAR) potentially involved in stomatal signalling, the gene for which encod...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05176
更新日期：2006-10-19 00:00:00
abstract：:Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/428486a
更新日期：2004-04-01 00:00:00
abstract：:The debate over human origins has focused on two competing theories. The single African origin model holds that anatomically modern Homo sapiens evolved in Africa 100,000-200,000 years ago. Members of this population migrated out of Africa, replacing archaic human groups through Asia and Europe, with racial differenti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/368452a0
更新日期：1994-03-31 00:00:00
abstract：:The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/321785a0
更新日期：1986-06-19 00:00:00
abstract：:Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of transcription ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2988-z
更新日期：2020-12-01 00:00:00
abstract：:Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35054017
更新日期：2001-01-25 00:00:00
abstract：:The promoter for a weakly expressed constitutive gene, the lactose repressor gene (lacI), has been sequenced, along with an 'up' promoter mutation Iq. The 10-fold enhancement in I expression found in Iq is the result of a single base change at position -35. To facilitate the sequencing, the lacI gene was cloned in a s...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/274762a0
更新日期：1978-08-24 00:00:00
abstract：:Microbialites, including biogenic stromatolites, thrombolites and dendrolites, were formed by various microbial mats that trapped and bound sediments or formed the locus of mineral precipitation. Microbialites were common and diverse during the Proterozoic, but declined in abundance and morphological diversity when mu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02654
更新日期：2004-07-01 00:00:00
abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/375503a0
更新日期：1995-06-08 00:00:00
abstract：:Large-scale systematic sequencing has generally depended on the availability of an ordered library of large-insert bacterial or viral genomic clones for the organism under study. The generation of these large insert libraries, and the location of each clone on a genome map, is a laborious and time-consuming process. I...
journal_title：Nature
pub_type： 杂志文章
doi：
更新日期：1997-05-29 00:00:00
abstract：:The three-dimensional structure of the 67K amino-terminal fragment of Escherichia coli DNA topoisomerase I has been determined to 2.2 A resolution. The polypeptide folds in an unusual way to give four distinct domains enclosing a hole large enough to accommodate a double-stranded DNA. The active-site tyrosyl residue, ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/367138a0
更新日期：1994-01-13 00:00:00
abstract：:At the molecular level, muscle contraction is the result of cyclic interaction between myosin crossbridges, which extend from the thick filament, and the thin filament, which consists mainly of actin. The energy for work done by a single crossbridge during a cycle of attachment, generation of force, shortening and det...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/355638a0
更新日期：1992-02-13 00:00:00
abstract：:Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/386414a0
更新日期：1997-03-27 00:00:00
abstract：:Promoters are DNA sequences that have an essential role in controlling gene expression. While recent whole cancer genome analyses have identified numerous hotspots of somatic point mutations within promoters, many have not yet been shown to perturb gene expression or drive cancer development. As such, positive selecti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature17437
更新日期：2016-04-14 00:00:00
abstract：:Materials showing simultaneous ferroelectric and magnetic ordering are attracting a great deal of interest because of their unusual physics and potential applications. Hemberger et al. have reported relaxor-like dielectric properties and colossal magnetocapacitance (in excess of 500%) for the cubic spinel compound CdC...
journal_title：Nature
pub_type： 评论,杂志文章
doi：10.1038/nature06156
更新日期：2007-08-23 00:00:00
abstract：:Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone-usher pathway2-5. The outer-membrane usher FimD recruits pilus subunits bound by the chaperone FimC via the periplasmic N-...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0587-z
更新日期：2018-10-01 00:00:00
abstract：:L-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors. Little is known about the physiological role of kainate receptors be...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/33408
更新日期：1998-04-09 00:00:00
abstract：:It is commonly assumed that certain features are so elementary to the visual system that they require no attentional resources to be perceived. Such 'preattentive' features are traditionally identified by visual search performance, in which the reaction time for detecting a feature difference against a set of distract...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/42940
更新日期：1997-06-19 00:00:00
abstract：:The injection of Rous sarcoma virus (RSV) into the wing web of newly hatched chicks causes a rapidly growing sarcomatous tumour which is palpable within 1 week of inoculation; and cultures of fibroblasts derived from chick embryos (CEF) and infected with RSV become rapidly transformed. Genetic studies have determined ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/309552a0
更新日期：1984-06-07 00:00:00
abstract：:Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and nonclassical role in the physiology of the neuron in that they release transmitter and protein, but little is known of the factors controlling release of substances from these dendrites. In this...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/333174a0
更新日期：1988-05-12 00:00:00
abstract：:Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14495
更新日期：2015-07-16 00:00:00
