Abstract:
:The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity. Here we describe a method-influence mapping-that uses single-neuron perturbations to directly measure how cortical neurons reshape sensory representations. In layer 2/3 of the primary visual cortex (V1), we use two-photon optogenetics to trigger action potentials in a targeted neuron and calcium imaging to measure the effect on spiking in neighbouring neurons in awake mice viewing visual stimuli. Excitatory neurons on average suppressed other neurons and had a centre-surround influence profile over anatomical space. A neuron's influence on its neighbour depended on their similarity in activity. Notably, neurons suppressed activity in similarly tuned neurons more than in dissimilarly tuned neurons. In addition, photostimulation reduced the population response, specifically to the targeted neuron's preferred stimulus, by around 2%. Therefore, V1 layer 2/3 performed feature competition, in which a like-suppresses-like motif reduces redundancy in population activity and may assist with inference of the features that underlie sensory input. We anticipate that influence mapping can be extended to investigate computations in other neural populations.
journal_name
Naturejournal_title
Natureauthors
Chettih SN,Harvey CDdoi
10.1038/s41586-019-0997-6subject
Has Abstractpub_date
2019-03-01 00:00:00pages
334-340issue
7748eissn
0028-0836issn
1476-4687pii
10.1038/s41586-019-0997-6journal_volume
567pub_type
杂志文章相关文献
NATURE文献大全abstract::Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14854
更新日期:2015-09-03 00:00:00
abstract::Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334359a0
更新日期:1988-07-28 00:00:00
abstract::A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11156
更新日期:2012-06-28 00:00:00
abstract::Spintronics relies on the transport of spins, the intrinsic angular momentum of electrons, as an alternative to the transport of electron charge as in conventional electronics. The long-term goal of spintronics research is to develop spin-based, low-dissipation computing-technology devices. Recently, long-distance tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0490-7
更新日期:2018-09-01 00:00:00
abstract::Temperature-sensitive paralysis is the most striking defect of adult Drosophila carrying the shibire mutation. This is believed to be due to a reversible block of endocytosis, which prevents membrane cycling and thus depletes synaptic vesicles. The shibire mutation also affects many tissues outside the nervous system....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351411a0
更新日期:1991-05-30 00:00:00
abstract::There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (>95%) show little evidence of evolutionary conservation and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07672
更新日期:2009-03-12 00:00:00
abstract::The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05825
更新日期:2007-06-14 00:00:00
abstract::Cyclosporin A (CSA) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. Clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of pati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289300a0
更新日期:1981-01-22 00:00:00
abstract::A large impact by a comet or meteorite releases an enormous amount of energy, which evaporates, melts and fractures the surrounding rocks. Distinctive features of such impacts are 'shatter cones', deformed rocks characterized by hierarchical striated features. Although such features have been used for decades as unequ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00903
更新日期:2002-07-18 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00043-x
更新日期:2019-01-01 00:00:00
abstract::Osteoarthritis-the most common form of age-related degenerative whole-joint disease1-is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral bone remodelling2,3. However, the molecular mechanisms that underlie the pathogenesis of osteoarthritis are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0920-1
更新日期:2019-02-01 00:00:00
abstract::Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2732-8
更新日期:2020-09-01 00:00:00
abstract::Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination reaction, which is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensitive to ionizing radiation. However, XRCC4 shares no sequence homology with ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/41358
更新日期:1997-07-31 00:00:00
abstract::Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415412a
更新日期:2002-01-24 00:00:00
abstract::Nuclear magic numbers correspond to fully occupied energy shells of protons or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. Although the sequence of magic numbers is well established for stable nucle...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1155-x
更新日期:2019-05-01 00:00:00
abstract::A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-021-03275-y
更新日期:2021-02-01 00:00:00
abstract::L-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors. Little is known about the physiological role of kainate receptors be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33408
更新日期:1998-04-09 00:00:00
abstract::Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12956
更新日期:2014-03-13 00:00:00
abstract::Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/35041555
更新日期:2000-11-09 00:00:00
abstract::The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309425a0
更新日期:1984-05-31 00:00:00
abstract::Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09697
更新日期:2011-01-27 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07165-8
更新日期:2018-11-01 00:00:00
abstract::Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/38310
更新日期:1997-09-11 00:00:00
abstract::Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differences and for elucidating the evolutionary history of the species. Large-scale polymorphism surveys have recently been reported for human, mouse and Arabidopsis thaliana...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07670
更新日期:2009-03-19 00:00:00
abstract::In 1975-79, joint expeditions from Yale University and the Geological Survey of Pakistan (YGSP) recovered fossil lorisids in the Siwalik Group of Pakistan from four localities, spanning a period before 10 Myr ago to about 7 Myr ago. In three of the localities, only isolated teeth or fragments were found, whereas the f...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/289585a0
更新日期:1981-02-12 00:00:00
abstract::Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant molecules, modern synthetic materials and commodity chemicals such as fuels and lubricants. Traditionally, the presence of a functional group is required at the site of C-C bond formation. Strategies that allow C-C bond formation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19810
更新日期:2016-11-10 00:00:00
abstract::The piezoelectric characteristics of nanowires, thin films and bulk crystals have been closely studied for potential applications in sensors, transducers, energy conversion and electronics. With their high crystallinity and ability to withstand enormous strain, two-dimensional materials are of great interest as high-p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13792
更新日期:2014-10-23 00:00:00
abstract::Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12504
更新日期:2013-09-05 00:00:00
abstract::Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01739
更新日期:2003-07-03 00:00:00
abstract::Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328150a0
更新日期:1987-07-09 00:00:00