Structure and elasticity of microtubule-associated protein tau.

Abstract:

:Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains a short-age of structural data on the protein. We have now prepared paracrystals of tau suitable for electron microscopy and image processing. They show distinct transverse banding and polarity, indicating that the protein subunits are aligned with the same orientations. In contrast to other paracrystals, those of tau protein can stretch or contract continuously by more than three-fold; the axial repeats range from 22 to 68 nm. After scaling to a common period, the density distributions are closely superimposable. This suggests that tau is an elastic molecule.

journal_name

Nature

journal_title

Nature

authors

Lichtenberg B,Mandelkow EM,Hagestedt T,Mandelkow E

doi

10.1038/334359a0

subject

Has Abstract

pub_date

1988-07-28 00:00:00

pages

359-62

issue

6180

eissn

0028-0836

issn

1476-4687

journal_volume

334

pub_type

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