Abstract:
:The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the rings together; a large loosely structured apical domain that forms the ends of the cylinder; and a small slender intermediate domain that connects the two, creating side windows. The three-dimensional structure places most of the mutationally defined functional sites on the channel walls and its outward invaginations, and at the ends of the cylinder.
journal_name
Naturejournal_title
Natureauthors
Braig K,Otwinowski Z,Hegde R,Boisvert DC,Joachimiak A,Horwich AL,Sigler PBdoi
10.1038/371578a0subject
Has Abstractpub_date
1994-10-13 00:00:00pages
578-86issue
6498eissn
0028-0836issn
1476-4687journal_volume
371pub_type
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