Genes that mediate breast cancer metastasis to lung.

abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...

journal_title：Nature

authors： Gack MU,Shin YC,Joo CH,Urano T,Liang C,Sun L,Takeuchi O,Akira S,Chen Z,Inoue S,Jung JU

更新日期：2007-04-19 00:00:00

abstract：:Fault strength is a fundamental property of seismogenic zones, and its temporal changes can increase or decrease the likelihood of failure and the ultimate triggering of seismic events. Although changes in fault strength have been suggested to explain various phenomena, such as the remote triggering of seismicity, the...

journal_title：Nature

authors： Taira T,Silver PG,Niu F,Nadeau RM

更新日期：2009-10-01 00:00:00

abstract：:Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...

journal_title：Nature

authors： de Godoy LM,Olsen JV,Cox J,Nielsen ML,Hubner NC,Fröhlich F,Walther TC,Mann M

更新日期：2008-10-30 00:00:00

abstract：:The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake,...

journal_title：Nature

authors： Galagan JE,Calvo SE,Cuomo C,Ma LJ,Wortman JR,Batzoglou S,Lee SI,Baştürkmen M,Spevak CC,Clutterbuck J,Kapitonov V,Jurka J,Scazzocchio C,Farman M,Butler J,Purcell S,Harris S,Braus GH,Draht O,Busch S,D'Enfert C,Bou

更新日期：2005-12-22 00:00:00

abstract：:Determining the chronology for the assembly of planetary bodies in the early Solar System is essential for a complete understanding of star- and planet-formation processes. Various radionuclide chronometers (applied to meteorites) have been used to determine that basaltic lava flows on the surface of the asteroid Vest...

journal_title：Nature

authors： Yin Q,Jacobsen SB,Yamashita K,Blichert-Toft J,Télouk P,Albarède F

更新日期：2002-08-29 00:00:00

abstract：:The violation of a Bell inequality is an experimental observation that forces the abandonment of a local realistic viewpoint--namely, one in which physical properties are (probabilistically) defined before and independently of measurement, and in which no physical influence can propagate faster than the speed of light...

journal_title：Nature

authors： Giustina M,Mech A,Ramelow S,Wittmann B,Kofler J,Beyer J,Lita A,Calkins B,Gerrits T,Nam SW,Ursin R,Zeilinger A

更新日期：2013-05-09 00:00:00

abstract：:Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show t...

journal_title：Nature

authors： Chai J,Du C,Wu JW,Kyin S,Wang X,Shi Y

更新日期：2000-08-24 00:00:00

abstract：:Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases. This response property has led to a hypothesis that dopamine neurons encode value-related signals and are inhibited by aversive events. Here we show that this is tr...

journal_title：Nature

authors： Matsumoto M,Hikosaka O

更新日期：2009-06-11 00:00:00

abstract：:Phase and antigenic variation of pilin expression in Neisseria gonorrhoeae result from recombination events in which variant sequences from one of the silent loci (pilS) are transferred to the expression locus (pilE). Such rearrangements were originally thought to be gene conversions, but findings showing that phase v...

journal_title：Nature

authors： Gibbs CP,Reimann BY,Schultz E,Kaufmann A,Haas R,Meyer TF

更新日期：1989-04-20 00:00:00

abstract：:Oral administration of antigen is used to induce antigen-specific peripheral immune tolerance. As well as preventing systemic immune responses to ingested proteins, oral tolerance to autoantigens has also been used to suppress autoimmune diseases in animals and humans. Both active suppression and clonal anergy are sug...

journal_title：Nature

authors： Chen Y,Inobe J,Marks R,Gonnella P,Kuchroo VK,Weiner HL

更新日期：1995-07-13 00:00:00

abstract：:For parallel computers to simulate our brains, we must face the fact that human beings have a better claim on the title Homo seriatim than Homo sapiens--we're more consistently serial than wise. ...

journal_title：Nature

authors： Calvin WH

更新日期：1987-11-05 00:00:00

abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...

journal_title：Nature

authors： Mróz P,Udalski A,Skowron J,Poleski R,Kozłowski S,Szymański MK,Soszyński I,Wyrzykowski Ł,Pietrukowicz P,Ulaczyk K,Skowron D,Pawlak M

更新日期：2017-08-10 00:00:00

abstract：:There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approxima...

journal_title：Nature

authors： Wellcome Trust Case Control Consortium.

更新日期：2007-06-07 00:00:00

abstract：:Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...

journal_title：Nature

authors： Wolff EW,Fischer H,Fundel F,Ruth U,Twarloh B,Littot GC,Mulvaney R,Röthlisberger R,de Angelis M,Boutron CF,Hansson M,Jonsell U,Hutterli MA,Lambert F,Kaufmann P,Stauffer B,Stocker TF,Steffensen JP,Bigler M,Siggaard-An

更新日期：2006-03-23 00:00:00

abstract：:The expression of immunodeficiency in patients with specific purine enzyme defects indicates a crucial role of the purine salvage pathway in the acquisition and expression of normal immune function. One current hypothesis links the failure of normal lymphocyte development in these diseases to the accumulation of deoxy...

journal_title：Nature

authors： Dosch HM,Mansour A,Cohen A,Shore A,Gelfand EW

更新日期：1980-06-12 00:00:00

abstract：:To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...

journal_title：Nature

authors： Gilbert MJ,Thornton CR,Wakley GE,Talbot NJ

更新日期：2006-03-23 00:00:00

abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

journal_title：Nature

authors： Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

更新日期：1991-02-21 00:00:00

abstract：:Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...

journal_title：Nature

authors： Feiler R,Harris WA,Kirschfeld K,Wehrhahn C,Zuker CS

更新日期：1988-06-23 00:00:00

abstract：:Aberrant neovascularization contributes to diseases such as cancer, blindness and atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although many regulators of pathogenic angiogenesis have been identified, our understanding of this process is incomplete. Here we explore the transcriptome ...

journal_title：Nature

authors： Wang X,Abraham S,McKenzie JAG,Jeffs N,Swire M,Tripathi VB,Luhmann UFO,Lange CAK,Zhai Z,Arthur HM,Bainbridge J,Moss SE,Greenwood J

更新日期：2013-07-18 00:00:00

abstract：:Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...

journal_title：Nature

authors： Galonić DP,Gin DY

更新日期：2007-04-26 00:00:00

abstract：:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a compl...

journal_title：Nature

authors： Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,N

更新日期：2014-10-02 00:00:00

abstract：:The extensive literature on the origin of the ratites focuses mainly on three questions: are the ratites mono- or polyphyletic, did they evolve from flying ancestors, and are they primitive or advanced? Opinion tends to accept a common descent from flying ancestors for the large ratites (for a summary of ideas see ref...

journal_title：Nature

authors： de Boer LE

更新日期：1980-09-04 00:00:00

abstract：:The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination3, which compr...

journal_title：Nature

authors： Kumar R,Flodén NJ,Whitehurst WG,Gaunt MJ

更新日期：2020-05-01 00:00:00

abstract：:Photosynthetic dinoflagellates are important aquatic primary producers and notorious causes of toxic 'red tides'. Typical dinoflagellate chloroplasts differ from all other plastids in having a combination of three envelope membranes and peridinin-chlorophyll a/c light-harvesting pigments. Despite evidence of a dinofla...

journal_title：Nature

authors： Zhang Z,Green BR,Cavalier-Smith T

更新日期：1999-07-08 00:00:00

abstract：:The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...

journal_title：Nature

authors： Mello CC,Conte D Jr

更新日期：2004-09-16 00:00:00

abstract：:A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...

journal_title：Nature

authors： Kumar S,Hedges SB

更新日期：1998-04-30 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the intracellular effectors SMAD2 and SMAD3 (hereafter SMAD2/3), whose canonical function is to control the activity of target genes by interacting with transcriptiona...

journal_title：Nature

authors： Bertero A,Brown S,Madrigal P,Osnato A,Ortmann D,Yiangou L,Kadiwala J,Hubner NC,de Los Mozos IR,Sadée C,Lenaerts AS,Nakanoh S,Grandy R,Farnell E,Ule J,Stunnenberg HG,Mendjan S,Vallier L

更新日期：2018-03-08 00:00:00

abstract：:The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of the...

journal_title：Nature

authors： Gidoni D,Dynan WS,Tjian R

更新日期：1984-11-29 00:00:00

abstract：:The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...

journal_title：Nature

authors： Pin JP,Bettler B

更新日期：2016-12-01 00:00:00