A short timescale for terrestrial planet formation from Hf-W chronometry of meteorites.

abstract：:Runs of adenines (adenine tracts) have been implicated as the main determinant of sequence-directed DNA bending. The most widely used experimental test for bending relies on the observation that bent DNA migrates more slowly than straight DNA on a polyacrylamide electrophoresis gel. It was shown recently that the poly...

journal_title：Nature

authors： Burkhoff AM,Tullius TD

更新日期：1988-02-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Hsiang S,Allen D,Annan-Phan S,Bell K,Bolliger I,Chong T,Druckenmiller H,Huang LY,Hultgren A,Krasovich E,Lau P,Lee J,Rolf E,Tseng J,Wu T

更新日期：2020-09-01 00:00:00

abstract：:In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...

journal_title：Nature

authors： Gao J,Barzel B,Barabási AL

更新日期：2019-04-01 00:00:00

abstract：:Generalization is a cognitive ability that allows similar stimuli along a given dimension to be treated as equivalents. Insects exhibit high levels of visual generalization. Honeybees trained to recognize complex visual stimuli on the basis of a single feature generalize their choice to novel stimuli sharing that comm...

journal_title：Nature

authors： Stach S,Benard J,Giurfa M

更新日期：2004-06-17 00:00:00

abstract：:Positron emission tomography (PET) measurements of brain blood flow were used to monitor changes in the human primary and secondary somatosensory cortices during the period when somatosensory stimuli were expected. In anticipation of either focal or innocuous touching, or localized, painful shocks, blood flow decrease...

journal_title：Nature

authors： Drevets WC,Burton H,Videen TO,Snyder AZ,Simpson JR Jr,Raichle ME

更新日期：1995-01-19 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:The ventral tegmental area (VTA) and nucleus accumbens (NAc) are essential for learning about environmental stimuli associated with motivationally relevant outcomes. The task of signalling such events, both rewarding and aversive, from the VTA to the NAc has largely been ascribed to dopamine neurons. The VTA also cont...

journal_title：Nature

authors： Brown MT,Tan KR,O'Connor EC,Nikonenko I,Muller D,Lüscher C

更新日期：2012-12-20 00:00:00

abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

journal_title：Nature

authors： Lindsley JE,Wang JC

更新日期：1993-02-25 00:00:00

abstract：:Nucleosomal DNA is arranged in a higher-order structure that presents a barrier to most cellular processes involving protein DNA interactions. The cellular machinery involved in sister chromatid cohesion, the cohesin complex, also requires access to the nucleosomal DNA to perform its function in chromosome segregation...

journal_title：Nature

authors： Hakimi MA,Bochar DA,Schmiesing JA,Dong Y,Barak OG,Speicher DW,Yokomori K,Shiekhattar R

更新日期：2002-08-29 00:00:00

abstract：:Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their exhaustion during adult ...

journal_title：Nature

authors： Hock H,Hamblen MJ,Rooke HM,Schindler JW,Saleque S,Fujiwara Y,Orkin SH

更新日期：2004-10-21 00:00:00

abstract：:Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands. In hum...

journal_title：Nature

authors： Deardorff MA,Bando M,Nakato R,Watrin E,Itoh T,Minamino M,Saitoh K,Komata M,Katou Y,Clark D,Cole KE,De Baere E,Decroos C,Di Donato N,Ernst S,Francey LJ,Gyftodimou Y,Hirashima K,Hullings M,Ishikawa Y,Jaulin C,Kaur

更新日期：2012-09-13 00:00:00

abstract：:Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated beta-catenin expands t...

journal_title：Nature

authors： Reya T,Duncan AW,Ailles L,Domen J,Scherer DC,Willert K,Hintz L,Nusse R,Weissman IL

更新日期：2003-05-22 00:00:00

abstract：:Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...

journal_title：Nature

authors： Rhee I,Jair KW,Yen RW,Lengauer C,Herman JG,Kinzler KW,Vogelstein B,Baylin SB,Schuebel KE

更新日期：2000-04-27 00:00:00

abstract：:The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and o...

journal_title：Nature

authors： Pashkovski SL,Iurilli G,Brann D,Chicharro D,Drummey K,Franks KM,Panzeri S,Datta SR

更新日期：2020-07-01 00:00:00

abstract：:Nanoscale electronic devices made from carbon nanotubes, such as transistors and sensors, are much smaller and more versatile than those that rely on conventional microelectronic chips, but their development for mass production has been thwarted by difficulties in aligning and integrating the millions of nanotubes req...

journal_title：Nature

authors： Rao SG,Huang L,Setyawan W,Hong S

更新日期：2003-09-04 00:00:00

abstract：:In platelets, agonists that stimulate phosphoinositide turnover cause the rapid phosphorylation of a protein of apparent relative molecular mass (Mr) 40-47,000, called P47, by protein kinase C (PKC). Diverse identities have been ascribed to P47 including lipocortin, inositol 1,4,5-trisphosphate 5-phosphomonoesterase, ...

journal_title：Nature

authors： Tyers M,Rachubinski RA,Stewart MI,Varrichio AM,Shorr RG,Haslam RJ,Harley CB

更新日期：1988-06-02 00:00:00

abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...

journal_title：Nature

authors： Schmid MF,Sherman MB,Matsudaira P,Chiu W

更新日期：2004-09-02 00:00:00

abstract：:The death of massive stars produces a variety of supernovae, which are linked to the structure of the exploding stars. The detection of several precursor stars of type II supernovae has been reported (see, for example, ref. 3), but we do not yet have direct information on the progenitors of the hydrogen-deficient type...

journal_title：Nature

authors： Pastorello A,Smartt SJ,Mattila S,Eldridge JJ,Young D,Itagaki K,Yamaoka H,Navasardyan H,Valenti S,Patat F,Agnoletto I,Augusteijn T,Benetti S,Cappellaro E,Boles T,Bonnet-Bidaud JM,Botticella MT,Bufano F,Cao C,Deng J,

更新日期：2007-06-14 00:00:00

abstract：:Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...

journal_title：Nature

authors： Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

更新日期：2011-05-19 00:00:00

abstract：:Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...

journal_title：Nature

authors： Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS

更新日期：2017-03-09 00:00:00

abstract：:The visual system analyses information by decomposing complex objects into simple components (visual features) that are widely distributed across the cortex. When several objects are present simultaneously in the visual field, a mechanism is required to group (bind) together visual features that belong to each object ...

journal_title：Nature

authors： Usher M,Donnelly N

更新日期：1998-07-09 00:00:00

abstract：:The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (proteins that mediate vesicle fusion) in neurons and observed changes in tr...

journal_title：Nature

authors： Bao H,Das D,Courtney NA,Jiang Y,Briguglio JS,Lou X,Roston D,Cui Q,Chanda B,Chapman ER

更新日期：2018-02-08 00:00:00

abstract：:There are large amounts of heavy alpha-emitters in nuclear waste and nuclear materials inventories stored in various sites around the world. These include plutonium and minor actinides such as americium and curium. In preparation for geological disposal there is consensus that actinides that have been separated from s...

journal_title：Nature

authors： Farnan I,Cho H,Weber WJ

更新日期：2007-01-11 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...

journal_title：Nature

authors： Gielen M,Siegler Retchless B,Mony L,Johnson JW,Paoletti P

更新日期：2009-06-04 00:00:00

abstract：:Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood....

journal_title：Nature

authors： Wan L,Chong S,Xuan F,Liang A,Cui X,Gates L,Carroll TS,Li Y,Feng L,Chen G,Wang SP,Ortiz MV,Daley SK,Wang X,Xuan H,Kentsis A,Muir TW,Roeder RG,Li H,Li W,Tjian R,Wen H,Allis CD

更新日期：2020-01-01 00:00:00

abstract：:A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads a...

journal_title：Nature

authors： Liu J,O'Brien KL,Lynch DM,Simmons NL,La Porte A,Riggs AM,Abbink P,Coffey RT,Grandpre LE,Seaman MS,Landucci G,Forthal DN,Montefiori DC,Carville A,Mansfield KG,Havenga MJ,Pau MG,Goudsmit J,Barouch DH

更新日期：2009-01-01 00:00:00

abstract：:Extremely intense and ultrafast X-ray pulses from free-electron lasers offer unique opportunities to study fundamental aspects of complex transient phenomena in materials. Ultrafast time-resolved methods usually require highly synchronized pulses to initiate a transition and then probe it after a precisely defined tim...

journal_title：Nature

authors： Chapman HN,Hau-Riege SP,Bogan MJ,Bajt S,Barty A,Boutet S,Marchesini S,Frank M,Woods BW,Benner WH,London RA,Rohner U,Szöke A,Spiller E,Möller T,Bostedt C,Shapiro DA,Kuhlmann M,Treusch R,Plönjes E,Burmeister F,Ber

更新日期：2007-08-09 00:00:00

abstract：:During biosynthesis, class II molecules of the major histocompatibility complex are associated with a nonpolymorphic protein called invariant chain, Ii, which facilitates folding of class II molecules and their exit from the endoplasmic reticulum, interferes with their association with peptide and directs their post-G...

journal_title：Nature

authors： Peterson M,Miller J

更新日期：1992-06-18 00:00:00

abstract：:Bananas (Musa spp.), including dessert and cooking types, are giant perennial monocotyledonous herbs of the order Zingiberales, a sister group to the well-studied Poales, which include cereals. Bananas are vital for food security in many tropical and subtropical countries and the most popular fruit in industrialized c...

journal_title：Nature

authors： D'Hont A,Denoeud F,Aury JM,Baurens FC,Carreel F,Garsmeur O,Noel B,Bocs S,Droc G,Rouard M,Da Silva C,Jabbari K,Cardi C,Poulain J,Souquet M,Labadie K,Jourda C,Lengellé J,Rodier-Goud M,Alberti A,Bernard M,Correa M

更新日期：2012-08-09 00:00:00

abstract：:Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...

journal_title：Nature

authors： Moxham CM,Malbon CC

更新日期：1996-02-29 00:00:00