Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.

abstract：:Variations in atmospheric radiocarbon (14C) concentrations can be attributed either to changes in the carbon cycle--through the rate of radiocarbon removal from the atmosphere--or to variations in the production rate of 14C due to changes in solar activity or the Earth's magnetic field. The production rates of 10Be an...

journal_title：Nature

authors： Muscheler R,Beer J,Wagner G,Finkel RC

更新日期：2000-11-30 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify,...

journal_title：Nature

authors： Froguel P,Vaxillaire M,Sun F,Velho G,Zouali H,Butel MO,Lesage S,Vionnet N,Clément K,Fougerousse F

更新日期：1992-03-12 00:00:00

abstract：:The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...

journal_title：Nature

authors： Kamikouchi A,Inagaki HK,Effertz T,Hendrich O,Fiala A,Göpfert MC,Ito K

更新日期：2009-03-12 00:00:00

abstract：:The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and TCF/LEF-dependent gene transactivation. Mutations in ...

journal_title：Nature

authors： Yan KS,Janda CY,Chang J,Zheng GXY,Larkin KA,Luca VC,Chia LA,Mah AT,Han A,Terry JM,Ootani A,Roelf K,Lee M,Yuan J,Li X,Bolen CR,Wilhelmy J,Davies PS,Ueno H,von Furstenberg RJ,Belgrader P,Ziraldo SB,Ordonez H,H

更新日期：2017-05-11 00:00:00

abstract：:The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...

journal_title：Nature

authors： Chia W,McGill S,Karp R,Gubb D,Ashburner M

更新日期：1985-07-04 00:00:00

abstract：:Hydrodynamic flow in classical and quantum fluids can be either laminar or turbulent. Vorticity in turbulent flow is often modelled with vortex filaments. While this represents an idealization in classical fluids, vortices are topologically stable quantized objects in superfluids. Superfluid turbulence is therefore th...

journal_title：Nature

authors： Finne AP,Araki T,Blaauwgeers R,Eltsov VB,Kopnin NB,Krusius M,Skrbek L,Tsubota M,Volovik GE

更新日期：2003-08-28 00:00:00

abstract：:In the unactivated Limulus sperm, a 60- micro m-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the acrosomal process. This bi...

journal_title：Nature

authors： Schmid MF,Sherman MB,Matsudaira P,Chiu W

更新日期：2004-09-02 00:00:00

abstract：:Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...

journal_title：Nature

authors： Bedo G,Santisteban P,Aranda A

更新日期：1989-05-18 00:00:00

abstract：:Jets of highly energized plasma with relativistic velocities are associated with black holes ranging in mass from a few times that of the Sun to the billion-solar-mass black holes at the centres of galaxies. A popular but unconfirmed hypothesis to explain how the plasma is energized is the 'internal shock model', in w...

journal_title：Nature

authors： Meyer ET,Georganopoulos M,Sparks WB,Perlman E,van der Marel RP,Anderson J,Sohn ST,Biretta J,Norman C,Chiaberge M

更新日期：2015-05-28 00:00:00

abstract：:Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...

journal_title：Nature

authors： Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

更新日期：2019-10-01 00:00:00

abstract：:Xenoturbellida and Acoelomorpha are marine worms with contentious ancestry. Both were originally associated with the flatworms (Platyhelminthes), but molecular data have revised their phylogenetic positions, generally linking Xenoturbellida to the deuterostomes and positioning the Acoelomorpha as the most basally bran...

journal_title：Nature

authors： Philippe H,Brinkmann H,Copley RR,Moroz LL,Nakano H,Poustka AJ,Wallberg A,Peterson KJ,Telford MJ

更新日期：2011-02-10 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identif...

journal_title：Nature

authors： Beroukhim R,Mermel CH,Porter D,Wei G,Raychaudhuri S,Donovan J,Barretina J,Boehm JS,Dobson J,Urashima M,Mc Henry KT,Pinchback RM,Ligon AH,Cho YJ,Haery L,Greulich H,Reich M,Winckler W,Lawrence MS,Weir BA,Tanaka KE,

更新日期：2010-02-18 00:00:00

abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...

journal_title：Nature

authors： Dingle EH,Attal M,Sinclair HD

更新日期：2017-04-26 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:The importance of the dopaminergic system in brain function has been emphasized by its association with neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. On the basis of their biochemical and pharmacological characteristics, dopamine receptors are classified into D1 and D2 subtypes....

journal_title：Nature

authors： Zhou QY,Grandy DK,Thambi L,Kushner JA,Van Tol HH,Cone R,Pribnow D,Salon J,Bunzow JR,Civelli O

更新日期：1990-09-06 00:00:00

abstract：:Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM cells generated by viral infection of the skin differentially ex...

journal_title：Nature

authors： Pan Y,Tian T,Park CO,Lofftus SY,Mei S,Liu X,Luo C,O'Malley JT,Gehad A,Teague JE,Divito SJ,Fuhlbrigge R,Puigserver P,Krueger JG,Hotamisligil GS,Clark RA,Kupper TS

更新日期：2017-03-09 00:00:00

abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...

journal_title：Nature

authors： Kim JS,Kim Y,Marti K,Kerridge JF

更新日期：1995-06-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Mallapaty S

更新日期：2018-12-01 00:00:00

abstract：:The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...

journal_title：Nature

authors： Tan S,Hunziker Y,Sargent DF,Richmond TJ

更新日期：1996-05-09 00:00:00

abstract：:Scrapie and related animal and human disorders are neurodegenerative diseases characterized by the formation of a modified, partly proteinase-resistant protein (PrP) of the host, which tends to aggregate as amyloid fibrils and accumulate in the brain of infected individuals. There is a general consensus that the patho...

journal_title：Nature

authors： Xi YG,Ingrosso L,Ladogana A,Masullo C,Pocchiari M

更新日期：1992-04-16 00:00:00

abstract：:Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation. RIPK1 is implicated in inflammatory and cell death signalling and its kinase activity is believed to drive RIPK3-mediated necroptosis. Here we show that kinase-independent s...

journal_title：Nature

authors： Dannappel M,Vlantis K,Kumari S,Polykratis A,Kim C,Wachsmuth L,Eftychi C,Lin J,Corona T,Hermance N,Zelic M,Kirsch P,Basic M,Bleich A,Kelliher M,Pasparakis M

更新日期：2014-09-04 00:00:00

abstract：:The homotypic fusion of yeast vacuoles includes a 'docking' step, which we show here to consist of two sequential reactions: a reversible 'tethering' mediated by the GTPase Ypt7, and 'SNARE pairing', in which SNARE proteins from opposite membranes form a complex in trans. The function of this trans-SNARE complex must ...

journal_title：Nature

authors： Ungermann C,Sato K,Wickner W

更新日期：1998-12-10 00:00:00

abstract：:The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...

journal_title：Nature

authors： Gemmell NJ,Rutherford K,Prost S,Tollis M,Winter D,Macey JR,Adelson DL,Suh A,Bertozzi T,Grau JH,Organ C,Gardner PP,Muffato M,Patricio M,Billis K,Martin FJ,Flicek P,Petersen B,Kang L,Michalak P,Buckley TR,Wilson M

更新日期：2020-08-01 00:00:00

abstract：:Following the introduction of silicon-based integrated circuitry over three decades ago, the integration density of such circuits has doubled every 12 to 18 months: this observation is known as Moore's law. For this historical trend to continue, significant challenges need to be overcome in several key technological a...

journal_title：Nature

authors： Peercy PS

更新日期：2000-08-31 00:00:00

abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

journal_title：Nature

authors： Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

更新日期：1991-02-21 00:00:00

abstract：:Molecular processes that govern pathogenic features of erythrocyte invasion and cytoadherence in malaria are reliant on Plasmodium-specific Duffy-binding-like domains (DBLs). These cysteine-rich modules recognize diverse host cell-surface receptors during pathogenesis. DBLs of parasite erythrocyte-binding proteins med...

journal_title：Nature

authors： Singh SK,Hora R,Belrhali H,Chitnis CE,Sharma A

更新日期：2006-02-09 00:00:00

abstract：:The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists w...

journal_title：Nature

authors： Morimoto C,Rudd CE,Letvin NL,Schlossman SF

更新日期：1987-12-03 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00